Protein Alignment SREBF1 and Srebf1

DIOPT Version :10

• Sequence 1: NP_001005291.1
• Gene: SREBF1 / 6720
• HGNCID: 11289
• Length: 1177
• Species: Homo sapiens
• Sequence 2: NP_001263636.1
• Gene: Srebf1 / 78968
• RGDID: 69423
• Length: 1134
• Species: Rattus norvegicus
• Alignment Length: 1178
• Identity: 925/1178 - (78%)
• Similarity: 993/1178 - (84%)
• Gaps: 45/1178 - (3%)

Human     1 MDEPPFSEAALEQALGEPCDLDAALLTDIEGEVGAGRGRANGLDAPRAGADRGAMDCTFEDMLQL 65
            |||.||.||||||||.|.|::||||||||                              ||||||
  Rat     1 MDELPFGEAALEQALAEVCEMDAALLTDI------------------------------EDMLQL 35

Human    66 INNQDSDFPGLFDPPYAGSGAGGTDPASPDTSSPGSLSPPPATLSSSLEAFLSGPQAAPSPLSPP 130
            |||||||||||||.||||...|.|.|:||..|||.|.| .||:|.|||||||.||:..|:|||||
  Rat    36 INNQDSDFPGLFDAPYAGGETGDTGPSSPGASSPESFS-SPASLGSSLEAFLGGPKVTPAPLSPP 99

Human   131 QPAPTPLKMYPSMPAFSPGPGIKEESVPLSILQTPTPQPLPGALLPQSFPAPAPPQFSSTPVLGY 195
            ..|||.:|||||:|.||||||||||.|||:|||.|.|||.||.|||.||| |.|.|.|..|||||
  Rat   100 PSAPTAVKMYPSVPPFSPGPGIKEEPVPLTILQPPAPQPSPGTLLPPSFP-PPPVQLSPAPVLGY 163

Human   196 PSPPGGFSTGSPPGNTQQPLPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVT 260
            .|.|.||| |:.||||||....|||.|.||:.|..|||||||...||    ....:|||..:||.
  Rat   164 SSLPSGFS-GTLPGNTQQTPSSLPLGSTPGISPTPLHTQVQSSAAQQ----PPPASAAPRMSTVA 223

Human   261 SQIQQVPVLLQPHFIKADSLLLTAMKTD-GATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATV 324
            ||||||||:|||||||||||||||:||| |||:|.||::.|..||.||.|||.||||||||||||
  Rat   224 SQIQQVPVVLQPHFIKADSLLLTAVKTDTGATMKTAGINTLAPGTAVQAGPLQTLVSGGTILATV 288

Human   325 PLVVDAEKLPINRLAAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNK 389
            |||||.:||||:|||||.||..|||||||||||||||||||||||||||:|||||||||||||||
  Rat   289 PLVVDTDKLPIHRLAAGGKALGSAQSRGEKRTAHNAIEKRYRSSINDKIVELKDLVVGTEAKLNK 353

Human   390 SAVLRKAIDYIRFLQHSNQKLKQENLSLRTAVHKSKSLKDLVSACGSGGNTDVLMEGVKTEVEDT 454
            ||||||||||||||||||||||||||:||:| |||||||||||||||||.|||.|||:|.||.:|
  Rat   354 SAVLRKAIDYIRFLQHSNQKLKQENLTLRSA-HKSKSLKDLVSACGSGGGTDVSMEGMKPEVVET 417

Human   455 LTPPPSDAGSPFQSSPLSLGSRGSGSGGSGSDSEPDSPVFEDSKAKPEQRPSLHSRGMLDRSRLA 519
            |||||||||||.||||||||||||.||  |||||||||.|||::.|.::.|| ||||||||||||
  Rat   418 LTPPPSDAGSPSQSSPLSLGSRGSSSG--GSDSEPDSPAFEDNQVKAQRLPS-HSRGMLDRSRLA 479

Human   520 LCTLVFLCLSCNPLASLLGARGLPSPSDTTSVYHSPGRNVLGTESRDGPGWAQWLLPPVVWLLNG 584
            ||.||||||:|||||||.| .|:.:|||.:.|:.|.||::|..|||||..|.||||||:|||.||
  Rat   480 LCVLVFLCLTCNPLASLFG-WGILTPSDASGVHRSSGRSMLEAESRDGSNWTQWLLPPLVWLANG 543

Human   585 LLVLVSLVLLFVYGEPVTRPHSGPAVYFWRHRKQADLDLARGDFAQAAQQLWLALRALGRPLPTS 649
            ||||..|.||||||||||||||||||:||||||||||||||||||||||||||||:|||||||||
  Rat   544 LLVLACLALLFVYGEPVTRPHSGPAVHFWRHRKQADLDLARGDFAQAAQQLWLALQALGRPLPTS 608

Human   650 HLDLACSLLWNLIRHLLQRLWVGRWLAGRAGGLQQDCALRVDASASARDAALVYHKLHQLHTMGK 714
            :|||||||||||:|||||||||||||||:|||||:|..||.||.|||||||:|||||||||.|||
  Rat   609 NLDLACSLLWNLVRHLLQRLWVGRWLAGQAGGLQRDYRLRKDARASARDAAVVYHKLHQLHAMGK 673

Human   715 HTGGHLTATNLALSALNLAECAGDAVSVATLAEIYVAAALRVKTSLPRALHFLTRFFLSSARQAC 779
            :|||||.|:||||||||||||||||:|:|||||||||||||||||||||||||||||||||||||
  Rat   674 YTGGHLVASNLALSALNLAECAGDAISMATLAEIYVAAALRVKTSLPRALHFLTRFFLSSARQAC 738

Human   780 LAQSGSVPPAMQWLCHPVGHRFFVDGDWSVLSTPWESLYSLAGNPVDPLAQVTQLFREHLLERAL 844
            |||||:||.|||||||||||||||||||:|...|.|||||:||||||||||||:||.||||||||
  Rat   739 LAQSGAVPLAMQWLCHPVGHRFFVDGDWAVHGAPQESLYSVAGNPVDPLAQVTRLFCEHLLERAL 803

Human   845 NCVTQPNPSPGSADGDKEFSDALGYLQLLNSCSDAAGAPAYSFSISSSMATTTGVDPVAKWWASL 909
            ||:.|  ||||:||||:||||||||||||||||||.||||.|||:|||||||||.||||||||||
  Rat   804 NCIAQ--PSPGAADGDREFSDALGYLQLLNSCSDAVGAPACSFSVSSSMATTTGTDPVAKWWASL 866

Human   910 TAVVIHWLRRDEEAAERLCPLVEHLPRVLQESERPLPRAALHSFKAARALLGCAKAESGPASLTI 974
            ||||||||||||||||||.|||||:|:||||:|||||||||:|||||||||...|.||.||||.|
  Rat   867 TAVVIHWLRRDEEAAERLYPLVEHIPQVLQETERPLPRAALYSFKAARALLDHRKVESSPASLAI 931

Human   975 CEKASGYLQDSLATTPASSSIDKAVQLFLCDLLLVVRTSLWRQQQPPAPAPAAQGTSSRPQASAL 1039
            ||||||||:||||:|..:||||||:||.|||||||.||||||:||..|.|..|.|||:.||||||
  Rat   932 CEKASGYLRDSLASTSTASSIDKAMQLLLCDLLLVARTSLWRRQQSAASAQGAHGTSNGPQASAL 996

Human  1040 ELRGFQRDLSSLRRLAQSFRPAMRRVFLHEATARLMAGASPTRTHQLLDRSLRRRAGPGGKGGAV 1104
            ||||||.||||||||||||||||||||||||||||||||||.|||||||||||||||..|||||.
  Rat   997 ELRGFQHDLSSLRRLAQSFRPAMRRVFLHEATARLMAGASPARTHQLLDRSLRRRAGSSGKGGAA 1061

Human  1105 AELEPRPTRREHAEALLLASCYLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLG 1169
            ||||||||.|||.||||||||||||.|||||||||.||||||||:|||||.|||.||||||:|||
  Rat  1062 AELEPRPTWREHTEALLLASCYLPPAFLSAPGQRVSMLAEAARTVEKLGDHRLLLDCQQMLLRLG 1126

Human  1170 GGTTVTSS 1177
            ||||||||
  Rat  1127 GGTTVTSS 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBF1	NP_001005291.1	Herpes_BLLF1	<79..350	CDD:282904	181/271 (67%)
		Atrophin-1	<117..>240	CDD:460830	81/122 (66%)
		bHLHzip_SREBP1	349..423	CDD:381491	69/73 (95%)
Srebf1	NP_001263636.1	Transcriptional activation (acidic). /evidence=ECO:0000250|UniProtKB:P36956	1..60		47/88 (53%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P36956	27..35		7/37 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	46..102		35/56 (63%)
		Atrophin-1	58..>230	CDD:460830	111/178 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..221		67/110 (61%)
		Interaction with LMNA. /evidence=ECO:0000250|UniProtKB:Q9WTN3	227..487		220/263 (84%)
		bHLHzip_SREBP1	313..384	CDD:381491	68/70 (97%)
		Leucine-zipper	367..388		18/21 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..468		41/55 (75%)
		COG3899	<562..1071	CDD:443106	440/510 (86%)