Protein Alignment SREBF1 and sre1

DIOPT Version :10

• Sequence 1: NP_001005291.1
• Gene: SREBF1 / 6720
• HGNCID: 11289
• Length: 1177
• Species: Homo sapiens
• Sequence 2: NP_595694.1
• Gene: sre1 / 2540730
• PomBaseID: SPBC19C2.09
• Length: 900
• Species: Schizosaccharomyces pombe
• Alignment Length: 958
• Identity: 219/958 - (22%)
• Similarity: 324/958 - (33%)
• Gaps: 355/958 - (37%)

Human    92 ASPDTSSPGSLS--PPPATLSSSLEAFLSGP-----------QAAPSPLSPPQPAPTPLKMYPSM 143
            ||||:.||.|:.  |..:.|:||.:|..|.|           .|:....|||....|.|
pombe    23 ASPDSKSPNSVGAIPSSSPLASSTKASTSTPFVENCSNLLCDLASIVEDSPPTLTNTSL------ 81

Human   144 PAFSPGPGIKEESVPLSILQTPTPQPLPGALLPQSFP---APAPPQFSSTPVLGYPSP------P 199
               ||      .|..||.:::    .:...|.|.:|.   ..|||.|:||. :|.|:.      |
pombe    82 ---SP------HSFSLSDMES----SMSNWLNPFAFDNTMNSAPPLFTSTN-MGSPNSLENSTNP 132

Human   200 GGFSTGSPPGNTQQPLPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVTSQIQ 264
            ...:.|||.....:...|      |.:.......::|    :|:..:.:..|..|      |.:|
pombe   133 LLSNCGSPNSFQNETFTG------PSLNEFDADDKIQ----RQMKILHSVDTIDP------STVQ 181

Human   265 QVPV--LLQPHFIKADSLLLTAMKTDGATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATVPLV 327
            ..|.  :..|........::|.|.|   |.|     |..|...::..|      ......::|
pombe   182 NYPSADMSNPEVKLKTEEIITPMDT---TCK-----PEPSAKKIKLSP------SSEDSCSIP-- 230

Human   328 VDAEKLPINR-LAAGSKAPAS-----AQSRGE-KRTAHNAIEKRYRSSINDKIIELKDLVVGTEA 385
               |.||.:. .:.||.:|:.     |...|: |:||||.||||||:::||:|.||:|.|....|
pombe   231 ---ETLPFSAPKSRGSLSPSETPDFVAGPGGKPKKTAHNMIEKRYRTNLNDRICELRDAVPSLRA 292

Human   386 ----------------------KLNKSAVLRKAIDYIRFLQHSNQKLKQEN--LSLRTAVHKSKS 426
                                  ||||..:|.||.:|||.|:..|::|::.|  ||.|.|.::..|
pombe   293 AAALRCGNSLDDEDLGGLTPARKLNKGTILAKATEYIRHLEAKNKELQKTNKQLSDRLAFYEDPS 357

Human   427 LKDLVSACGSGGNTDVLMEGVKTEVEDTLTPPPSDAGSPFQSSPLSLGSRGSGSGGSGSDSEPDS 491
                                        :.||.:|             :|...|....|.|  |.
pombe   358 ----------------------------MAPPSND-------------TRAVNSVNVVSSS--DY 379

Human   492 PVFEDSKAKPEQR----PSLHSRGMLDRSRLALCTLVFLCLSCNPLASLLGARGLPSPSDTTSVY 552
            .|.:.|:....||    |:|::.|     |.||..:|.|.|.
pombe   380 SVHQSSRPNLTQRAFTSPTLNTMG-----RTALNGMVGLGLF----------------------- 416

Human   553 HSPGRNVLGTESRDGPGWAQWLLPPVVW-------LLNGLLVLVSLVLLFVY-----------GE 599
                 |..|.:|.... :..:.|||.:.       |.|.|.:.|.|:.||..           ||
pombe   417 -----NYFGNDSSQSV-YGLFALPPFLMSPFTGTVLFNMLKIGVVLLGLFYLLHDNSLFKGFKGE 475

Human   600 P----VTRPHSGPAVYFWR---HRKQADLDLARGDFAQAAQQLWLALRALGRPLPTSHLDLACSL 657
            .    .||....|:...:|   ..|...||                           |.....||
pombe   476 KKSKVSTRSSMSPSSILFRKTVFEKYCLLD---------------------------HSTSTISL 513

Human   658 LWNLIRHLLQRLWVGRWLAGRAGGLQQDCALRVDASASARDAALVYHKLHQLHTMGKHTGGHLTA 722
            .:.|:...|:..:                             ..:.|:|..|:|         ::
pombe   514 FFGLLIFTLKSAY-----------------------------GYLTHRLSALYT---------SS 540

Human   723 TNLALSALNLAE------------CAGDAVSVATLAEIYVAAALRVKTSLPRALHFLTRFFLSSA 775
            .|...|...|||            ..||| .|..|..:.|.|:   ..|||.:.|       :.|
pombe   541 ENWVYSEQQLAEVRNMEKLLDAQLMGGDA-KVDRLRLLMVFAS---SFSLPPSSH-------TCA 594

Human   776 RQACLAQ----SGSVPPAMQWLCHPVGHRFFVDGDWSVLSTPWESLYSLAGNPVDPLAQVTQLFR 836
            .||...|    :.|||.|:...|    ..||    |:            |.......:.|....|
pombe   595 LQAMYCQLIFSNTSVPSAIVSKC----VAFF----WN------------AAKKQHSKSSVHAELR 639

Human   837 EHLLERALNCVTQPNPSPGSADGDKEFS-DALGYLQLLNSCS-DAAGAPAYSFSISSSMATTTGV 899
            | |.|...|.:.       ::..|..|| :.:..|.:|..|: |:|   ..|.||.||::....:
pombe   640 E-LPECTANLIE-------NSHADDVFSPNMVERLWVLAKCTRDSA---QMSDSIISSLSDVLVL 693

Human   900 DP---VAKWWAS--LTAVVIHWLRRDEEAAE-----RLCP----LVEH 933
            .|   :|.|:|:  |.|:::..|.|..|.:|     .|||    ::.|
pombe   694 SPLEVLASWYAADLLDALLMESLSRKVEISEIEEIISLCPKNSSIIRH 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBF1	NP_001005291.1	Herpes_BLLF1	<79..350	CDD:282904	66/287 (23%)
		Atrophin-1	<117..>240	CDD:460830	31/142 (22%)
		bHLHzip_SREBP1	349..423	CDD:381491	38/98 (39%)
sre1	NP_595694.1	bHLHzip_scHMS1_like	259..354	CDD:381405	37/94 (39%)
		DUF2014	516..766	CDD:430604	68/306 (22%)