DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BRCA1 and brca1

DIOPT Version :9

Sequence 1:NP_009231.2 Gene:BRCA1 / 672 HGNCID:1100 Length:1884 Species:Homo sapiens
Sequence 2:XP_012807962.2 Gene:brca1 / 733513 XenbaseID:XB-GENE-490624 Length:1655 Species:Xenopus tropicalis


Alignment Length:2046 Identity:542/2046 - (26%)
Similarity:818/2046 - (39%) Gaps:621/2046 - (30%)


- Green bases have known domain annotations that are detailed below.


Human     1 MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPS-QCPLC 64
            :..|.:.:|.::|||:.|||.|||||||||:||||:|||||||||||||:||::||..: .||||
 Frog    59 LSCSRMDIEGIRNVISVMQKNLECPICLELMKEPVATKCDHIFCKFCMLQLLSKKKKENVPCPLC 123

Human    65 KNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENN--------SPEHLKDE 121
            |.::|:||||||.||..|||.|||||.||:||:|.::     |..:||.        ....:|::
 Frog   124 KTEVTRRSLQESHRFKLLVEGLLKIIKAFELDSGCKF-----FPSQENTVSGFESTIKDVLIKED 183

Human   122 VSIIQSMGYRNRAKRLLQSE--PENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELGS 184
            ..::...|||||.|.:|:|:  ....:|.|:....|.:.|.|..|...:::.:.:.:.:::....
 Frog   184 QPVVHCKGYRNRKKGILKSKTFEVTGTLLESKPEAQFAKLVTRLTSCRQKKHRKEASPIFVNCVP 248

Human   185 DSS---------------------EDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEF 228
            |||                     |||:|......||..:                    |.|||
 Frog   249 DSSECHLLNNESGSGNDRSPLCEKEDTLNPDMEAMVGSDQ--------------------AECEF 293

Human   229 SETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLT 293
            ||| ...|..:.|.::......:.:||.:                  .||.|:|..:...:....
 Frog   294 SET-AERTGSNLPGSDGPGCITETSAETN------------------VNTAANSNIYAREAEQYL 339

Human   294 KDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETC-NDRRTPSTEKKVD---------------- 341
            .:.:...|.:..::..|    |:||         | |....|:.|...|                
 Frog   340 NEHLCRFKQDIADRVHQ----RNQH---------CGNVPFVPNLETNFDEEETIETDFDNQYDDS 391

Human   342 --LNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDE----LLGSDD--- 397
              .|.||||:     ..||                :..|.::||||..:::|    ||..:|   
 Frog   392 NPQNIDPLCK-----VAKL----------------MRRSTERVNEWLLKTNEESSTLLAEEDSSF 435

Human   398 ----------SHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSV 452
                      |..|...||    |::.||::..|...|....|..|                   
 Frog   436 SVFPLQNKEPSEKGSCSSN----DLMPVLHKHAEQGTSGSVFDKQA------------------- 477

Human   453 ESNIEDKIFGKTY-RKKASLP--NLSHVTENLIIGAFVTEPQIIQERPLTNKLKR------KRRP 508
             ..::||||.|.| |::.|||  |::.|.|.....:|.|..:        ||..|      ||:.
 Frog   478 -VGVKDKIFCKVYKRQQKSLPPNNITCVVEVHRDSSFGTGTE--------NKTLRMDQLMCKRKI 533

Human   509 TSGLHPE--------------DFIKKADLAVQKTPEMINQ--GTNQTEQNGQVMNITNSGHENKT 557
            ..||:||              |.|.:||:......:..::  ..:|:|    :::.|.:...|..
 Frog   534 AHGLNPENLAITNGSINIYPDDCISEADVEQDAQSKACSELADADQSE----LVHCTYTVDGNTP 594

Human   558 KGDSIQNEKNPNPIESLEKESAFKTKAE--------PISSSISNMELELNIHNSKAPKKNRLRRK 614
            |...:  |...|.:|:.|::.....:..        .:.|..|..|..|              .:
 Frog   595 KKRCV--ESLANALETREEQKKLSCERSQKKKCCTWAVQSVASEPETRL--------------LQ 643

Human   615 SSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAK 679
            ||..|:..| ||.|:::..|                 |...||  ||.||.||::.|        
 Frog   644 SSCGHLDLL-LVSSQSIDDP-----------------KNVINQ--VRRSRRLQMLPG-------- 680

Human   680 KSNKPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPS-LPREEKEEKLETVKVSNN 743
                             ..|..::|| |...|..|.::.:..:..| ...:||....:||.....
 Frog   681 -----------------LLEKAISNA-GFEPKIKNANQQQNGIQSSKFKVKEKNPMSDTVPSQMK 727

Human   744 AEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESISLLEVSTLGKAKTEPNK-------C 801
            .:|...|..:.:   .|:.|:..           |::|.:.:.:.||....|...|.       |
 Frog   728 KKDMFCLPFTSD---DTDTSMND-----------GSEEGVPMRKGSTRNHDKVHCNDGDCDTLLC 778

Human   802 VSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKR 866
            |::.....|.|                                 |.|||||:.|.:...||.|||
 Frog   779 VTESDVQPNDK---------------------------------ETEESELETQQIVKMFKTSKR 810

Human   867 QSFAPFSNPGNAEEECATFS----------------AHSGSLKKQSPKVTFECEQKEENQGKNES 915
            .||...|....|..|....|                :..||.|:||..:|            |||
 Frog   811 TSFILDSRAAEAVAEVTLSSDILQVKASYDVEYRDVSSLGSAKEQSSALT------------NES 863

Human   916 NIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETGLITPNKHGLLQNPYRI 980
            :  |......::..|   ...|....||                         :|||.:      
 Frog   864 S--PSSEPKKSSSLP---WHKKRKQQAK-------------------------SKHGKM------ 892

Human   981 PPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNIN 1045
                         |:..                                  |||     |....|
 Frog   893 -------------CRSR----------------------------------REN-----SKPTDN 905

Human  1046 EVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNC-KHPEIK 1109
            ...|....:..|.|.||...:             ||:.:..|.  ..:|||.:  ::| ..|.| 
 Frog   906 RAKSPIINMSHSSNTIGQPAD-------------LNSPIHGGT--GSIYKQVI--NHCPTRPNI- 952

Human  1110 KQEYEEVVQTVN------TDFSPYLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKE-DTSFAE 1167
              :.|.:..:.|      ||.||...:.|      ::....|.|.|||.||...:..| ::|..:
 Frog   953 --DGEYINASANGSQSSVTDKSPAHFNIN------TNFICDVNSATPDGLLHSMDNAEGNSSLGD 1009

Human  1168 NDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQ-----GYRRGAKKLESSEENLSSEDEELPCFQ 1227
            ..:.:          :|:.:..|..|..:.:.:     |.::...|::||||..|.:|       
 Frog  1010 TTVHD----------EGKNAAHPESFLPSSVHRSVGLTGEKKCIPKVQSSEEGSSGDD------- 1057

Human  1228 HLLFGKVNNIPSQSTRHSTVATECLSKNTE-------ENLLSLKNSLND--CSNQVILAKASQEH 1283
              |.|.......:|...|:.||:  .||::       .||.....|.|.  .:::.:|.||... 
 Frog  1058 --LLGSQGLFCQKSKCVSSGATD--QKNSKNPGNAQRRNLPDFSGSSNSGKYNSREMLCKAVFP- 1117

Human  1284 HLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQSESQGVG---LSDKELVSDDE 1345
            .||:|::||.|||||    |.:::..:..:|           |:.:..|:|   .:::..:|.||
 Frog  1118 SLSQESQCSVSLFSS----LSNMSQQSANED-----------HKLQGGGLGSPSRTEETTISSDE 1167

Human  1346 ERGTGL-EENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQ 1409
            |..|.. :::||     :.::.| ||.||||.|.:.|.|.||||.::|.|||||.|:.:|.||||
 Frog  1168 ETLTAAPQDHNQ-----NPDIAE-ASECESEASHTGDSSLLSSQDELLNTQQRDYMKDSLKKLQQ 1226

Human  1410 EMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKDSHIHGQRNNSMFSKRPREHI- 1473
            |||.|||||||||:|..::..:.|..:   |.:...::...||:.   .|.:||:....|:... 
 Frog  1227 EMAALEAVLEQHGTQNLSAGTACIPSA---EHVTYRQEEAVEKEI---AQGDNSIVRTPPKPDAN 1285

Human  1474 -SVLTSQKSSEYPISQN-------PEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWY 1530
             |.|..|.:.....|:|       |..||    :..|:.:|.:...|.:..|...|         
 Frog  1286 GSALIGQSTDNGLQSRNRSMSPAPPHFLS----QTRAEKNTQERVGPAMGISKVLK--------- 1337

Human  1531 MHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGIS----- 1590
                      ::..::.:|....|:|...:..:.|.|..|:|....::....|.|.:..|     
 Frog  1338 ----------KSLVTEHKLEVRPDLETANVMPANPMDAKESSGQSSENKSENPILRNKCSTSHQG 1392

Human  1591 LFSDDPES-----DPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAME 1650
            |||...|.     :|.:.||                   :..:|..:.||..|..:     .|..
 Frog  1393 LFSYSMEEAVSPHNPKQSRA-------------------EFGIARKSTSPTFASPS-----RAKV 1433

Human  1651 ESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAE 1715
            .||..:.|.:::     .:.:|.|.|||...|..:|.:|:|.....|:..||:.||||:||||||
 Frog  1434 LSVGIKSPVVSS-----RRNLSFVASGLNQSELAVVQRFSRTTQSILSTRITDSTTHVIMKTDAE 1493

Human  1716 FVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRK 1780
            .|||||||||.||||.||||||.||.||.||.::|:|:||||:|||:|||||:||:|:|...|..
 Frog  1494 LVCERTLKYFQGIAGRKWVVSYEWVVQSFKEGQVLDEYDFEVKGDVINGRNHRGPRRSRLGSDGL 1558

Human  1781 IFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDA-WTEDNGFHA 1844
            :.:..|||..|.||:|..|.|||||..||::||::|...........:|:||.|| .||...:.|
 Frog  1559 LLKDFEICFSGLFTDMTLDDLEWMVSECGSTVVRDLQFPKNKLNTTSLVIVQTDANTTEIRDYFA 1623

Human  1845 IGQMCEAPVVTREWVLDSVALYQCQELDTYL 1875
            |.:..:|.||||||:|||:|.|:.|:.||||
 Frog  1624 IRKNHKAIVVTREWLLDSIATYRLQKFDTYL 1654

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BRCA1NP_009231.2 RING 23..68 CDD:238093 34/45 (76%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..270 6/39 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 306..338 7/32 (22%)
BRCT_assoc 345..507 CDD:289581 45/187 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 534..570 6/37 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 654..709 13/54 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1181..1216 9/39 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1322..1387 21/68 (31%)
Interaction with PALB2. /evidence=ECO:0000269|PubMed:19369211 1397..1424 20/26 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1586..1617 8/40 (20%)
BRCT 1671..1745 CDD:237994 45/73 (62%)
BRCT 1779..1863 CDD:214602 36/84 (43%)
brca1XP_012807962.2 RING-HC_BRCA1 76..124 CDD:319412 36/47 (77%)
rad18 80..>186 CDD:273165 61/110 (55%)
BRCT_assoc 408..>500 CDD:403887 30/115 (26%)
BRCT_BRCA1_rpt1 1449..1545 CDD:349367 59/95 (62%)
BRCT_BRCA1_rpt2 1558..1655 CDD:349353 44/97 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 129 1.000 Domainoid score I24518
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 480 1.000 Inparanoid score I7951
NCBI 1 1.000 - -
OMA 1 1.010 - - QHG51748
OrthoDB 1 1.010 - - D113563at32523
OrthoFinder 1 1.000 - - FOG0013864
OrthoInspector 1 1.000 - - oto149866
Panther 1 1.100 - - LDO PTHR13763
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X11403
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1111.080

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