DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SRD5A2 and Srd5a2

DIOPT Version :9

Sequence 1:	NP_000339.2	Gene:	SRD5A2 / 6716	HGNCID:	11285	Length:	254	Species:	Homo sapiens
Sequence 2:	NP_073202.1	Gene:	Srd5a2 / 64677	RGDID:	621480	Length:	254	Species:	Rattus norvegicus

Alignment Length:	254	Identity:	197/254 - (77%)
Similarity:	218/254 - (85%)	Gaps:	0/254 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPA 65
            ||:.|.|.|||||||||..:|.|.|.:.||:.|||||||:......||||.||||||||||.|..
  Rat     1 MQIVCHQVPVLAGSATLATMGTLILCLGKPASYGKHTESVSSGVPFLPARIAWFLQELPSFVVSV 65

Human    66 GILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYL 130
            |:||.||.|||||||.|||.||..|||||||:||||.||||:||:|.||.||||.|||:||.|||
  Rat    66 GMLAWQPRSLFGPPGNVLLALFSAHYFHRTFIYSLLTRGRPFPAVLFLRATAFCIGNGLLQAYYL 130

Human   131 IYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFL 195
            :||||||:.||||:|||.|||||||||||||||||.|||||||||:.||||:|||||||||||||
  Rat   131 VYCAEYPEEWYTDVRFSFGVFLFILGMGINIHSDYTLRQLRKPGEVIYRIPRGGLFTYVSGANFL 195

Human   196 GEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF 254
            |||||||||||||||:||.|||||:|||||::||:|||||||||:||||||||||||||
  Rat   196 GEIIEWIGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFKDYPKSRKALIPFIF 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRD5A2	NP_000339.2	Steroid_dh	105..254	CDD:251363	125/148 (84%)
Srd5a2	NP_073202.1	Steroid_dh	105..254	CDD:251363	125/148 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83680343
Domainoid	1	1.000	282	1.000	Domainoid score	I16641
eggNOG	1	0.900	-	-		E1_KOG1638
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37292
Inparanoid	1	1.050	425	1.000	Inparanoid score	I12870
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG62721
OrthoDB	1	1.010	-	-		D1574389at2759
OrthoFinder	1	1.000	-	-		FOG0001983
OrthoInspector	1	1.000	-	-		oto140530
orthoMCL	1	0.900	-	-		OOG6_102555
Panther	1	1.100	-	-	LDO	PTHR10556
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1297
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310