DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRD5A2 and SPAC9.08c

DIOPT Version :9

Sequence 1:	NP_000339.2	Gene:	SRD5A2 / 6716	HGNCID:	11285	Length:	254	Species:	Homo sapiens
Sequence 2:	NP_593351.1	Gene:	SPAC9.08c / 2543655	PomBaseID:	SPAC9.08c	Length:	282	Species:	Schizosaccharomyces pombe

Alignment Length:	277	Identity:	84/277 - (30%)
Similarity:	122/277 - (44%)	Gaps:	49/277 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    17 LVALGALALYVAKPSGYGKHTESLKP-AATRLPARAAWFLQELPS-----FAVPAGILARQPLSL 75
            :|.:....|:|..|  :||..:..|. :...:..|..|.|.||.:     :|:.........|..
pombe    14 VVGVFPCTLFVNAP--HGKLAKQSKLFSKGYISGRVGWVLMELVAPLTFLYAIRNNRHFESTLPS 76

Human    76 FGPPGT---------VLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTG------NGVL 125
            .|....         ||.|:|.:||.:|..|..||..    |.:..:..|.|.:.      ||:.
pombe    77 LGDGSNRDYLDSCRKVLAGMFLVHYANRALVSPLLMA----PQVSPMHWTVFVSAVLFNFLNGMS 137

Human   126 QGYYLIYCA--EYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRK-------PGEIS---- 177
            .|.||:..:  .:|   .:.||..:|:||:::|...|::.|.||..||:       |..:.
pombe   138 IGLYLVQASVQHHP---VSIIRRYIGMFLWLMGWLGNMYHDNILYDLRRSSNKKKDPDNLDTVQS 199

Human   178 ----YRIPQGGLFTYVSGANFLGEIIEWIG-YALATWSLPALAFAFFSLCFLGL-RAFHHHRFYL 236
                ||||.||||.|||..|:..|.|||.| |..|..|.....:.|.|...|.| ||...|::|.
pombe   200 ENSYYRIPYGGLFQYVSCPNYFCEWIEWFGCYLAAGPSAEPFWWFFLSEILLMLPRALKAHQWYC 264

Human   237 KMFEDYPKSRKALIPFI 253
            |.|..||.:|:|:|||:
pombe   265 KKFPKYPANRRAIIPFL 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRD5A2	NP_000339.2	Steroid_dh	105..254	CDD:251363	59/174 (34%)
SPAC9.08c	NP_593351.1	PEMT	118..281	CDD:304400	57/165 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	86	1.000	Domainoid score	I2479
eggNOG	1	0.900	-	-		E1_KOG1638
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I1798
OMA	1	1.010	-	-		QHG62721
OrthoFinder	1	1.000	-	-		FOG0001983
OrthoInspector	1	1.000	-	-		otm53979
orthoMCL	1	0.900	-	-		OOG6_102555
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1836
SonicParanoid	1	1.000	-	-		X1297
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.800