DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRC and src-1

DIOPT Version :9

Sequence 1:	XP_016883513.1	Gene:	SRC / 6714	HGNCID:	11283	Length:	542	Species:	Homo sapiens
Sequence 2:	NP_001364829.1	Gene:	src-1 / 171722	WormBaseID:	WBGene00005077	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	485	Identity:	262/485 - (54%)
Similarity:	333/485 - (68%)	Gaps:	22/485 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    69 SSDTVTSPQRAGPLAGGV---TTFVALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLA 130
            :||.:....|.|...||.   .|.||||.|:||.:.||||:||:.:.:::::      ..|||..
Worm    57 TSDGMMGNGRGGGGGGGAQERETLVALYPYDSRADGDLSFQKGDAMYLLDHS------NCDWWYV 115

Human   131 HSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCL 195
            ....||||||:|.|:||...:|::||||.|||.|..:|||:|::..|:||||:||.|.....:.|
Worm   116 RHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFAL 180

Human   196 SVSDFDNAK-GLNVKHYKIRKLD-SGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSK 258
            ::.|.|:.: |..||||||::|| ..|::||:|..|.|||:||.|||...||||.:||...|...
Worm   181 TIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLA 245

Human   259 PQTQGLAKDA---WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEA 320
            |....|:.|.   |||||..|.|:.|||.|.|||||.|.|.|...|||||:||||||||||||||
Worm   246 PTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEA 310

Human   321 QVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 384
            |:||:..|..||:||||.: |||.||:||||..||||.:|:.: |..|.:..|||||||||:||.
Worm   311 QIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTD-GSTLGIQALVDMAAQIANGMM 374

Human   385 YVERMNYVHRDLRAANILVGENL----VCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAAL 444
            |:|....|||||.|.|:|||:.:    |.||||||||| |:|::.|.||.||||||||||||||.
Worm   375 YLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAAT 439

Human   445 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH-DLMCQCW 508
            .|.||:||||||:||||.|:.|||:||||||.||||::|||.|||||.|..|||.:: :::.:||
Worm   440 CGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCW 504

Human   509 RKEPEERPTFEYLQAFLEDYFTSTEPQYQP 538
            .|.|:.||||:.|..|.:|||.||:|.|.|
Worm   505 DKTPDRRPTFDTLYHFFDDYFVSTQPNYAP 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRC	XP_016883513.1	SH3_Src	88..149	CDD:212941	27/60 (45%)
		SH2_Src_Src	153..253	CDD:198228	51/101 (50%)
		PTKc_Src	266..542	CDD:270656	174/283 (61%)
src-1	NP_001364829.1	SH3_Src_like	79..130	CDD:212779	24/56 (43%)
		SH2_Src_family	138..240	CDD:199827	51/101 (50%)
		PTKc_Src_like	270..522	CDD:270630	158/252 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I713
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	513	1.000	Inparanoid score	I772
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm15767
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3222
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900