Protein Alignment SPTBN2 and beta-Spec

DIOPT Version :10

• Sequence 1: NP_001397954.1
• Gene: SPTBN2 / 6712
• HGNCID: 11276
• Length: 2397
• Species: Homo sapiens
• Sequence 2: NP_001259660.1
• Gene: beta-Spec / 32746
• FlyBaseID: FBgn0250788
• Length: 2308
• Species: Drosophila melanogaster
• Alignment Length: 2367
• Identity: 1126/2367 - (47%)
• Similarity: 1544/2367 - (65%)
• Gaps: 122/2367 - (5%)

Human    54 RFKQLQDEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRM 118
            |.|.|.:|||:||||||||||||||.||.||:.|||.|:|||::|::||||||||.|||||||:|
  Fly    40 RIKALAEERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKM 104

Human   119 RIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKK 183
            |||||||||||||||:||:|||||:|||||||||..|.|||:||||||||||||::|..||||.|
  Fly   105 RIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKETK 169

Human   184 SAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAF 248
            |||||||||||||||||.||||.|||||||||||||||:|||||||:.||.|.|.||.:||.|||
  Fly   170 SAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAF 234

Human   249 NLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERL 313
            ::||.:|||.||||.|||.|:.||||||||||.||||||||:|...|:|||||||:..|||.:::
  Fly   235 DVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVVGIAMENDKM 299

Human   314 VEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFT 378
            |..||:..|:||:|||.||.:|.:|:..|||:|||.||..|::|||:||||||.|||||||||||
  Fly   300 VHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFT 364

Human   379 IQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAM 443
            :|||:||||||.|||:||::|||||||||||||||||||||||.|||||||||||||||||||:|
  Fly   365 LQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKLEQLAARFDRKASM 429

Human   444 RETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKR 508
            ||||||||||||||||||.:|||||||.:|||||||||.||..|||||.||..||.:|||||:||
  Fly   430 RETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDVKR 494

Human   509 IAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGV 573
            |..|:.||.|||.:|.:::.|||.||.::|:||:.||::||::|.|||:|..|.:.|.|:||.||
  Fly   495 ILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKHLMGV 559

Human   574 EDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKE-YRPCDPQLVSERVAKLEQSYEALCELA 637
            |||||.|.||||||.:..|||:.|..::.:|.:...| |:||||:::..||.:||.:|..|..||
  Fly   560 EDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLA 624

Human   638 AARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLG 702
            ..||:||||||:||:|.|:..:.|.|::|::.::::.:.|.|||....:|:||.||..|::....
  Fly   625 VERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSHDP 689

Human   703 PLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDME 767
            .|:...:.|.:|:.|||.||.:...|..|:..:|:.|..|.:.|.|||..|...:|..|||:|::
  Fly   690 QLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVD 754

Human   768 AWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQS 832
            .|::|.||:|||.::|.||.:.|:|.::|:.:.:|::::...:|||.:||.:|....:....|..
  Fly   755 NWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKANVDK 819

Human   833 RVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVV 897
            |:..::..|:||...|..|.:.|..||:||.::|||.....|::||.:.|:.:...:.:||:|::
  Fly   820 RLEAIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIM 884

Human   898 QQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALT 962
            :.|||..:.|||..|:::..||.:|.|||....|..|.|:..|..||..|...|..|:.|...|.
  Fly   885 KHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLK 949

Human   963 SALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTR 1027
            ||..:|.:::||.||.:|:.:|.:::..|..|..||.||:.|||:|:|.:|||.||.|::..|.|
  Fly   950 SAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLER 1014

Human  1028 EANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQ 1092
            |||::...||.:|..|..|:.:::..||.|...::.|:..|.||..|..|||.||.||.||.:||
  Fly  1015 EANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQ 1079

Human  1093 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQA---DPQCLFLRQRL 1154
            |.||||:.|.:|||||.||.||.::|.|::....:|..:...||.:|.:.:   |||.:|||:||
  Fly  1080 TDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERL 1144

Human  1155 EALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIK 1219
            .||..|||||.:|||:||..|:|:...|.|.|||||.|.:||.||:.||..:.|..|:.|:..:|
  Fly  1145 NALKDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLK 1209

Human  1220 KLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDN 1284
            :.|.|::||:||.::|:.||:....||.:.:..||||.::|::|..|...|:..|.....:|::.
  Fly  1210 RHEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQ 1274

Human  1285 REQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRE 1349
            .:...||||..||..|:.||..|:||.||..|:.:|:||.:||||.||:||||:.|.:.:|..:|
  Fly  1275 VKLHEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQE 1339

Human  1350 LTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLH 1414
            |:.||||.|.::..||::|.:::|:||..|:.|...||||||..|..|:|..::|::..|:.|:.
  Fly  1340 LSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIV 1404

Human  1415 SDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQA----KALAQEDQGAGEVERTSRAVEE 1475
            |.|...||||||||::|||:::.:|||:.::||.|..|.    |.:.:|......|::|  ||.|
  Fly  1405 SGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKT--AVLE 1467

Human  1476 KFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTL 1540
            :|..:..|:.||.:.|:..:|..||.||||||.||:.|:||:|:|.::|..|.:|.:|.||||:|
  Fly  1468 RFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSL 1532

Human  1541 QKEIQGHEPRIADLRERQRALGAAAAGPE--------LAELQEMWKRLGHELELRGKRLEDALRA 1597
            ..||..|||||..:....|.|  ...|.|        :::|.:.|:.|...:|.|.|.|.::.:.
  Fly  1533 ATEIDNHEPRINAICNNGRKL--IDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKV 1595

Human  1598 QQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMI 1662
            ||::.||.|||:||.||||:||.:::.|||:|||..:|||:.|||::.|||.||.||...::...
  Fly  1596 QQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFS 1660

Human  1663 DHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASH 1727
            ..:......::::|:|:||||||||:||||||.||.|.|:|..|.||:|||||||.:|||||.|.
  Fly  1661 GDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQ 1725

Human  1728 ELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWAD 1792
            |||||::|||:|.::|.||:|||..:|.|||...|.:|:.||..||:..||:|||||:|||:|.|
  Fly  1726 ELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQD 1790

Human  1793 LLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQ 1857
            ||||::||.|:|||:.||.:|.|..:..|.|:..||..:.|..|||..:...|||:|..:..|:.
  Fly  1791 LLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTLQRKHYNFLQDLI 1855

Human  1858 ALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKA 1922
            .|..||||:|::..:||.|||||||:||....|.|..||..||....||:|.|.||.|.||||..
  Fly  1856 TLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNM 1920

Human  1923 VRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYA 1987
            ||.||:||:::..||:..|:|||||..:|::.|.|.:||||:.|.|.|.:||.:|||||.|:|||
  Fly  1921 VRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYA 1985

Human  1988 AEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTV 2052
            :.:|.::|..|...|.....:|:|:.:.|||:|||..|.|||.:|||||.:|||.:.|:|||.|:
  Fly  1986 SADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTI 2050

Human  2053 DEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPG 2117
            ||||:|||:||||:|||.|.||||.|||:||..|.:|.:|:::..||..|
  Fly  2051 DEVENLIKKHEAFEKSAAAQEERFSALERLTTFELKEMKRRQELAEEAER--------------- 2100

Human  2118 DLVGGQTASDTTWDGTQPRPPPSTQAPSVNGVCTDGEPSQPLLGQQRLEHSSFPEGPGPGSGDEA 2182
                                                         ||::.    |.....:.:.|
  Fly  2101 ---------------------------------------------QRIKE----EQEAKAASEAA 2116

Human  2183 NGPRGERQTRTRGPAPSAMPQSRSTESA-----HAATLPPRGPEPSAQEQMEGMLCRKQEMEAFG 2242
            ...:.|.:.|......::...|.:.::|     .......||..|.|.|..||.:.||.|.::..
  Fly  2117 EQAKREAERRDDVDVGASHDDSAAKDTAVEFERVVEIQTERGGTPGAGEGHEGYVTRKHEWDSTT 2181

Human  2243 KKAANRSWQNVYCVLRRGSLGFYKDAKA--ASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKL 2305
            |||:||||..||...:.|.:.||||.|.  ::..:.:.||....|..|...:|.||.|:|||.::
  Fly  2182 KKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKKKHVLRV 2246

Human  2306 GLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPVVPSTTRGMTRAMTMPPVSPVGA 2370
            .|.:|..:|.||.|:.|||.|:        |:..|..:       ||....:|:.|:|..|
  Fly  2247 KLANGALFLLQAHDDTEMSQWV--------TSLKAQSD-------STAVAASRSQTLPATS---- 2292

Human  2371 EGPVVLRSKDGREREREKRFSFFKKNK 2397
                        :::..||.|||...|
  Fly  2293 ------------QKDEPKRRSFFTLKK 2307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPTBN2	NP_001397954.1	CH_SPTB-like_rpt1	52..166	CDD:409095	87/111 (78%)
		CH_SPTBN2_rpt2	180..298	CDD:409170	90/117 (77%)
		Spectrin	312..421	CDD:395348	77/108 (71%)
		Spectrin	436..529	CDD:395348	67/92 (73%)
		SPEC	541..753	CDD:238103	90/212 (42%)
		SPEC	756..965	CDD:238103	72/208 (35%)
		SPEC	968..1179	CDD:238103	96/213 (45%)
		SPEC	1181..1390	CDD:238103	87/208 (42%)
		SPEC	1391..1595	CDD:238103	82/215 (38%)
		SPEC	1596..1808	CDD:238103	118/211 (56%)
		SPEC	1809..2017	CDD:238103	92/207 (44%)
		SPEC	2025..>2082	CDD:197544	39/56 (70%)
		dnaA	<2104..>2248	CDD:455861	21/148 (14%)
		PH_beta_spectrin	2228..2331	CDD:269975	41/104 (39%)
beta-Spec	NP_001259660.1	CH_SPTB-like_rpt1	36..152	CDD:409095	87/111 (78%)
		CH_SPTB_like_rpt2	169..273	CDD:409097	82/103 (80%)
		Spectrin	298..408	CDD:395348	78/109 (72%)
		SPEC	422..521	CDD:197544	71/98 (72%)
		SPEC	525..740	CDD:238103	91/214 (43%)
		SPEC	639..846	CDD:238103	66/206 (32%)
		SPEC	848..1058	CDD:238103	77/209 (37%)
		SPEC	955..1169	CDD:238103	96/213 (45%)
		SPEC	1170..1380	CDD:238103	87/209 (42%)
		SPEC	1386..1484	CDD:197544	36/99 (36%)
		SPEC	1488..1699	CDD:238103	96/212 (45%)
		SPEC	1594..1806	CDD:238103	118/211 (56%)
		SPEC	1807..2015	CDD:238103	92/207 (44%)
		Spectrin	2018..>2078	CDD:395348	40/59 (68%)
		PH_beta_spectrin	2167..2274	CDD:269975	42/114 (37%)