DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SPTBN1 and Actn

DIOPT Version :9

Sequence 1:NP_003119.2 Gene:SPTBN1 / 6711 HGNCID:11275 Length:2364 Species:Homo sapiens
Sequence 2:NP_001259165.1 Gene:Actn / 31166 FlyBaseID:FBgn0000667 Length:917 Species:Drosophila melanogaster


Alignment Length:1106 Identity:317/1106 - (28%)
Similarity:504/1106 - (45%) Gaps:288/1106 - (26%)


- Green bases have known domain annotations that are detailed below.


Human     1 MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVN 65
            |...::.:|.:..::|:          ::|:.|......:|:.            ||||||.|.|
  Fly     3 MENGLSMEYGDGYMEQE----------EEWEREGLLDPAWEKQ------------QKKTFTAWCN 45

Human    66 SHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHL 130
            |||.:....|.::..|.|:|..|:.||||:|||.||||.:|:||.|.:.||:|||.|:..:.|||
  Fly    46 SHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHL 110

Human   131 ENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNI 195
            .::|:.:|||||.::|||:||||||||.||||||      |:.:||:.||||||.|||.|.|||:
  Fly   111 VSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV------EEMTAKEGLLLWCQRKTAPYKNVNV 169

Human   196 HNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPED-ISVD 259
            .||..|::||:||.||||:|||||||:.||.|.|...||..||::||::|.:.::|||:| |:..
  Fly   170 QNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTP 234

Human   260 HPDEKSIITYVVTYYHYFSKMKALA----------------------VEGKRIGKVLDNAIETEK 302
            .|||::|:|||..|||.|...:.:.                      ....||.|||....|.|:
  Fly   235 KPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENER 299

Human   303 MIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLF 367
            ::|:||.|||||||||.:|:..||:|:..|||.|||::|:.:.|||...|||:..:|..||....
  Fly   300 LMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFN 364

Human   368 TIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAA 432
            |:|:|:|.:|:..|:|.|||.:|||:.:|:.||.||...|..|..|.:|.|:||.||::|..||.
  Fly   365 TLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKAD 429

Human   433 MRETWL-SENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDI 496
            ..|.|. .:.:.|.|||.....|..::|..|||||.|:|:||:::||:.:.|:|:||....|||.
  Fly   430 AHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDC 494

Human   497 KRITARKDNVIRLWEYLLELLRARRQRL-EMNLGLQKIFQEMLYI---------MDWMDEMKVLV 551
            ..:.||...:...|:.|..|.:.||..| |....|:||  ::|::         .:|:|..:   
  Fly   495 VSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKI--DILHLEFAKRAAPFNNWLDGTR--- 554

Human   552 LSQDYGKHLLGVEDLLQK---HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRV 613
                        |||:..   ||:.|....||                                 
  Fly   555 ------------EDLVDMFIVHTMEEIQGLIQ--------------------------------- 574

Human   614 AHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLS 678
            ||.:|            :|.|.|:.:.:.....:      :||.|.|:........|.:....|:
  Fly   575 AHDQF------------KATLGEADKEFNLIVNL------VREVESIVKQHQIPGGLENPYTTLT 621

Human   679 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA 743
                 .::|:.:.....|.:.:.:..:|.|                          :||::..| 
  Fly   622 -----ANDMTRKWSDVRQLVPQRDQTLANE--------------------------LRKQQNNE- 654

Human   744 SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQAS 808
            .|..||...|:.:..|:...:..|::..:|. :.|.:..:.:.|:..:.:..|:|.::       
  Fly   655 MLRRQFAEKANIVGPWIERQMDAVTAIGMGL-QGSLEDQLHRLKEYEQAVYAYKPNIE------- 711

Human   809 ALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLN 873
                                       ||.::. ||:|:::.....::.                
  Fly   712 ---------------------------ELEKIH-QAVQESMIFENRYTN---------------- 732

Human   874 NMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKA-QQDKLNTRW 937
                    ..:|.::..:|.|...:|..      :|::..|::      .::.|. .|::||...
  Fly   733 --------YTMETLRVGWEQLLTSINRN------INEVENQIL------TRDSKGISQEQLNEFR 777

Human   938 SQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTK--VIESTQDLGNDLAGVMALQRKLTG 1000
            |.|.                   |.:.|.|.....|:.|  ::.....:|.|..|.:..||.|..
  Fly   778 SSFN-------------------HFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQGDLDFQRILAV 823

Human  1001 MERD---LVAIEAKLSDLQKEA-------------------------EKLESE-HPDQAQAILSR 1036
            ::.:   .|..:|.|..:.:|:                         ::|..| .||||:..:.|
  Fly   824 VDPNNTGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQR 888

Human  1037 L 1037
            :
  Fly   889 M 889

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SPTBN1NP_003119.2 Actin-binding 2..275 126/273 (46%)
CH_SPTBN1_rpt1 3..156 CDD:409165 59/152 (39%)
SAC6 48..>530 CDD:227401 228/506 (45%)
CH_SPTB_like_rpt2 173..277 CDD:409097 59/104 (57%)
Spectrin 1. /evidence=ECO:0000255 303..411 51/107 (48%)
Spectrin 2. /evidence=ECO:0000255 423..525 39/103 (38%)
SPEC 530..743 CDD:238103 32/224 (14%)
Spectrin 3. /evidence=ECO:0000255 530..636 19/117 (16%)
Spectrin 4. /evidence=ECO:0000255 639..742 12/102 (12%)
SPEC 642..849 CDD:238103 29/206 (14%)
Spectrin 5. /evidence=ECO:0000255 745..847 15/101 (15%)
Spectrin 6. /evidence=ECO:0000255 850..952 12/102 (12%)
SPEC 851..1061 CDD:238103 34/219 (16%)
Spectrin 7. /evidence=ECO:0000255 957..1060 22/112 (20%)
SPEC 958..1169 CDD:238103 22/111 (20%)
Spectrin 8. /evidence=ECO:0000255 1063..1166
Spectrin 9. /evidence=ECO:0000255 1170..1258
SPEC 1171..1380 CDD:238103
Spectrin 10. /evidence=ECO:0000255 1276..1376
SPEC 1381..1592 CDD:238103
Spectrin 11. /evidence=ECO:0000255 1381..1482
Spectrin 12. /evidence=ECO:0000255 1486..1590
Interaction with ANK2. /evidence=ECO:0000269|PubMed:15262991 1563..2093
SPEC 1593..1805 CDD:238103
SPEC 1806..2027 CDD:238103
Spectrin 2017..>2075 CDD:395348
Spectrin 17. /evidence=ECO:0000255 2018..2097
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2089..2196
Mediates interaction with CAMSAP1. /evidence=ECO:0000269|PubMed:24117850 2149..2177
PH_beta_spectrin 2200..2305 CDD:269975
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2309..2364
ActnNP_001259165.1 CH_ACTN_rpt1 31..135 CDD:409063 54/115 (47%)
CH_ACTN_rpt2 139..252 CDD:409065 66/118 (56%)
SPEC 302..525 CDD:238103 96/222 (43%)
SPEC 420..647 CDD:238103 70/325 (22%)
SPEC 538..760 CDD:238103 50/385 (13%)
EFh 775..842 CDD:238008 16/85 (19%)
EFhand_Ca_insen 847..913 CDD:400872 7/43 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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