DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SPTB and kst

DIOPT Version :10

Sequence 1:NP_001020029.1 Gene:SPTB / 6710 HGNCID:11274 Length:2328 Species:Homo sapiens
Sequence 2:NP_001097492.2 Gene:kst / 38418 FlyBaseID:FBgn0004167 Length:4337 Species:Drosophila melanogaster


Alignment Length:2220 Identity:678/2220 - (30%)
Similarity:1140/2220 - (51%) Gaps:221/2220 - (9%)


- Green bases have known domain annotations that are detailed below.


Human    40 FERSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPT 104
            ||..|||.|.:||..:||||||||:||.|.:....:.||:.||.||..|:||||::|.|.|.||.
  Fly    61 FENERIKTLQEERLHIQKKTFTKWMNSFLIKAKMEVEDLFTDLADGIKLLKLLEIISSEKLGKPN 125

Human   105 KGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDI---VVQT 166
            .|:||:|.:|||:|:|.|| ..:|.||::|:.||||||.||:||||||||||||||:|   |.:.
  Fly   126 SGRMRVHKIENVNKSLAFL-HTKVRLESIGAEDIVDGNPRLILGLIWTIILRFQIQEIEIDVDEE 189

Human   167 QEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKL---KDS 228
            .|..|.||||||||||||.||.|||.||:|:||:||:.||.||||||.|||||.::..:   |:|
  Fly   190 NESSEKRSAKDALLLWCQRKTHGYPGVNITDFTNSWRSGLGFNALIHSHRPDLFEYSTIVNSKNS 254

Human   229 NARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKV 293
            |. .||.|||:.|..:|||..|||.||:.:..||||||:|||.::||.|::||.....|||:..:
  Fly   255 NL-DNLNHAFDTAANELGIPSLLDAEDIDSARPDEKSILTYVASYYHTFARMKNEQKSGKRIANI 318

Human   294 IDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQE 358
            :...::.::...:|.||.::||:||.|....|..|...|||.|:|::|.||..|||:|||||::|
  Fly   319 VGQLMDADRKKMQYEGLTTNLLSWIRQKTLELEQRDLPNSLEGIQRELLAFKEYRTIEKPPKYKE 383

Human   359 KGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQL 423
            :..:|.|.|||.:.::|.||..|.|.||:||:||.:||:.||.||:.||:|||:||:||||||||
  Fly   384 RSEIEALYFTINTLLKALNQPPYNPQDGQLVNDIEKAWQILEYAEHHREVALRDELLRQEKLEQL 448

Human   424 ARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQEL 488
            ..:|::|:.:||.:|.|..::::...:   |..|:|..||||||..|..|..||...|..:|:||
  Fly   449 NYKFEKKSVLREGYLKEMIQVLSDPRY---LRQVDATLKKHEAISADILARVERFNDLTAMAEEL 510

Human   489 EKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLS 553
            ::||||.::|:..|:..::..|..|.|||:::|..|.....|..|.:::..:.:.:.|::....|
  Fly   511 DRENYHGKERVRRREQEVMAKWRQLLELLENQRLNLSQMSNLMNLLREIASTTEAVRELQQQFAS 575

Human   554 AEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQC 618
            .:.|.|||.||:|||.|.|.|..:...|:.:|......|.:   |..:..|..::..|::.||:.
  Fly   576 EDVGPHLLGVEELLQAHSLQELQVNTYGETLKRFNRQALPY---KSSEHKDAALLAQRLADLEEA 637

Human   619 FEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
            :.||...:|.|:|:||:::....|..:.|..|||:.:|::|..:....|||.:||.||:||||.|
  Fly   638 YSELLRRSAARRARLEEARNFHHFMEDYDNEESWLVDKQRICKTGITAKDLRAVLSLQQKHKALE 702

Human   684 DELRGLDAHLEQIFQEAHGMVARKQFGHP---QIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF 745
            ||::.......|:......::..:   ||   :|::||..::..|..|:.|....::.|:||...
  Fly   703 DEIKSRKPKSGQMSTAGKRLIGEQ---HPRSSEIQSRIDSLAEHWQALEALVELRRRQLEDAAEA 764

Human   746 FQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQA---- 806
            :||..||::.::||.:...|::..|.|.||.:.:||.::|:|...||....|.:.:|.|||    
  Fly   765 YQFYTDANEAESWLNEKIALVNSRDYGNDEPSAQALLQRHRDLQGELNAYSGDILNLNQQADKLI 829

Human   807 ----------------------------------------------------------------- 806
                                                                             
  Fly   830 KAGICTLELSAAEPELPEVEQEEWVNETRLVPKEVWEDEWVEKLEHKKVTETKMLPHVKSLFPFE 894

Human   807 -------------------------------QGF-PEEF-------------------------- 813
                                           :|| |..:                          
  Fly   895 GQGMKMDKGEVMLLKSKTNDDWWCVRKDNGVEGFVPANYVREVEPRPVACIVPKAEKVKSLQKVK 959

Human   814 -----------------------------------RDSPDVTHRLQALRELYQQVVAQADLRQQR 843
                                               .::..|..|.|.:.:.|.::...|..|...
  Fly   960 KTILVRQVVPVKRIKPVSVAPKPLVQRRTSTQSINENADSVEKRQQRINQTYDELQEMAQKRHAL 1024

Human   844 LQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVN 908
            |::::.|:..:.|.|..|.||.|||:    |...|..|.::..:.:|:....::.....:::.::
  Fly  1025 LEDSIHLFGFYRECDDFEKWMKEKER----MIKSDEGEGVDNAKRKFEKFITDLSAASKRVEEID 1085

Human   909 LAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDK 973
            .|.::....||.:..::...|..::..||......::|.::::.|..|..:...|:|...|:::|
  Fly  1086 GAVDTFRRQGHSQLDKIIARQRQIHQIWQRLNNAKAQREKSLEGASSVELFNRTCDEAKVWMSEK 1150

Human   974 TKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
            ...:: |..:..||..:.|:||:...|||::|.::.:|:.:......:.:::|.:|:::..||:.
  Fly  1151 MLQLD-TAVITPDLRTVQALQRRHQNLERELAPVEDKVNRVTYLGNSVKNAYPAEKDNVNARQQE 1214

Human  1039 LEELWQGLQQSLQGQE---DLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLL 1100
            ::::||.:||  :|.:   .:..||.| |.|........||:...:..:.:::....:..|..||
  Fly  1215 VQDMWQQVQQ--RGSDLRNRIESEVGQ-QVFNNSAKVLLAWIDSVKDQLNADESARDVETANNLL 1276

Human  1101 QQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
            ::|..:.|:|..|...:..|.:.|:::..|:  |........:|.|....:|:.|.|..:...|.
  Fly  1277 KKHNDLGDDIRAHDTEFVEVIQLGKQLSDGK--PNMAETVAVIERLKAEQDAIHRGWAEKQKWLL 1339

Human  1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPV-D 1229
            ||:..|.|.::|.:.:|...:.|..|.:.....||:..||.:::..||..|: ..:||:|... |
  Fly  1340 QCVDLQMFNREADKIDATTKSHEAFLEYNNLGASLDEVEAILKRHLDFEKSL-MAQDKILKGFSD 1403

Human  1230 SGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL 1294
            :.:||::..:..|..|.::...:..:.:...::|.|...||:.:.:...|.....:|.:|:.||.
  Fly  1404 NADKLISNDHYDSKYIGDRRNQVLGKRKAVKDRAFERKRLLQASKDFHKFAAEADDLKVWLQDKT 1468

Human  1295 LTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLM---DEKPQFTALVSQKLEA 1356
            ..:.|.:|.:..||..|..|||||..||.::||.|.|:..:|:.|:   :..|:    |..::..
  Fly  1469 RIAGDENYRDLSNLPRKLQKHQAFERELRANEGQLRNVTKDGQALVQAGNRVPE----VESRVAD 1529

Human  1357 LHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
            |::.|.:|...:::|.:.|..|.|.....::..|..|.:..::..|||.|.|.||.|...::.|.
  Fly  1530 LNKRWKDLLTLSEDKGRKLEQAASQREHNRSLEDAKKKVDELDSALRSGDVGNDLRSCKDLINKQ 1594

Human  1422 KRVEDQVNVRKEELGELFAQVPSMGE---------EGGDADLSIEKRFLDLLEPLGRRKKQLESS 1477
            :.:|.::.:..:::.||.:....|..         |.|..:|  ::||.||.:|..||:.:||.|
  Fly  1595 QILESEITIWDQKVAELVSTGDDMAHGGHFNAQNIEAGTKEL--QQRFKDLRDPTQRRRAKLEES 1657

Human  1478 RAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQ 1542
            ....:...:|:.|..|:.|.||.|:|.:.|.||...|...||::.|:.||.||.|.:...|..||
  Fly  1658 LNYHKFVFELDSEFQWINEHLPAAKSNELGQNLHQAQSLHKKHKKLEAEIKGHQPMINKALVAGQ 1722

Human  1543 QLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYV 1607
            .|:.....:.:.:|.....|:.:|..|......|.::|..:.:||||..||.|.|:|:||:...:
  Fly  1723 SLISQQHPEREQVESLCQQLEQAWQDLERHCGERSRKLDMSLKAQQYLFDAGEIESWLGERNNVL 1787

Human  1608 ISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHY 1672
            .|.|..:|.:.|..:|.:|...:..::.|...:.::......:::|.||:.:.:...|..::|..
  Fly  1788 RSTEYGRDRDSAAKLLTKHKTIELELDTYSGIVTEMGHSCAAMVAANHPDSKVLAAKQQLIEKML 1852

Human  1673 AGLKDVAEERK-RKLENMY-HLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDF 1735
            ..|..:|.:|: |.:|::| |.:.|  |:|::||||.|:|..|||.:.||||:|:.||::||.|.
  Fly  1853 KSLHKLASQRQGRLMESLYKHEYFL--ESDEVEQWIREQEQAASSEDYGQDFEHLQLLQNKFDDL 1915

Human  1736 ARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH 1800
            .... .:|.:|||......::|||:....|..:.:.::.|...|.:||:|::.|.|.|.|:.::|
  Fly  1916 KHRV-EVGADRVDQCELLAKKLIDSESPYANEVEKRQEQLRTSWENLLQLLNQREQKLHAAGEIH 1979

Human  1801 RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTA 1865
            |:....||.|..|.:|:..|.:::|.|.::|.:..|.|..||.:|..|..|:|...:.:.|||..
  Fly  1980 RFHRDVAEALFRIQDKNAALSQELGRDLNSALALLRKHEGFENDLVALEAQLQVLVEDSVRLQAK 2044

Human  1866 YAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQE 1930
            |. ..|.||..::.:|.|||..|.:....|..:|..::|...|.:..||::||..::...::.:|
  Fly  2045 YP-SNASAIAQQQDKVVAAWNDLKERSTARGDRLAASSDLQTFLTDVRDIVSWSSNLRAALQAEE 2108

Human  1931 RPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMN 1995
            ...|.:....|...|..|..|||.|...|....||.:|::|..|.|:.::.||...::..|::::
  Fly  2109 HVSDAAGATALKIQHDAIYGEIEAREDKFRYLNELSDSMVQTGHYAAADVEEKCAAMLDERQKLH 2173

Human  1996 EKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
            ..|..:...|...:::..|.|||...:....:|:..|:|.|||.||:.|:..|::|:.||:...:
  Fly  2174 AAWNKKKIMLEQKIDLFCFLRDAKQIDNLSSSQQAALSSSDFGQTVEDVQNKIRKHDEFERLIQT 2238

Human  2061 WAERFAALEK 2070
            ..|:.:.|::
  Fly  2239 QEEKVSLLQE 2248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SPTBNP_001020029.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
Actin-binding 2..275 139/240 (58%)
CH_SPTBN2_rpt1 25..156 CDD:409166 66/115 (57%)
CH_SPTB_rpt2 170..281 CDD:409168 67/113 (59%)
Spectrin 302..412 CDD:395348 53/109 (49%)
Spectrin 1. /evidence=ECO:0000255 303..411 52/107 (49%)
Spectrin 422..525 CDD:395348 37/102 (36%)
Spectrin 2. /evidence=ECO:0000255 423..525 36/101 (36%)
Spectrin 3. /evidence=ECO:0000255 529..635 30/105 (29%)
SPEC 530..742 CDD:238103 62/214 (29%)
Spectrin 4. /evidence=ECO:0000255 638..741 31/105 (30%)
SPEC 641..848 CDD:238103 65/371 (18%)
Spectrin 5. /evidence=ECO:0000255 744..846 32/263 (12%)
SPEC 745..954 CDD:238103 52/370 (14%)
Spectrin 6. /evidence=ECO:0000255 851..950 19/98 (19%)
SPEC 955..1168 CDD:238103 50/215 (23%)
Spectrin 7. /evidence=ECO:0000255 956..1058 25/104 (24%)
Spectrin 8. /evidence=ECO:0000255 1062..1165 21/102 (21%)
SPEC 1170..1379 CDD:238103 55/212 (26%)
Spectrin 9. /evidence=ECO:0000255 1170..1257 21/87 (24%)
Spectrin 10. /evidence=ECO:0000255 1275..1375 29/102 (28%)
SPEC 1385..1475 CDD:197544 25/98 (26%)
Spectrin 11. /evidence=ECO:0000255 1389..1465 22/84 (26%)
Spectrin 12. /evidence=ECO:0000255 1481..1582 30/100 (30%)
SPEC 1485..1690 CDD:238103 58/205 (28%)
Spectrin 13. /evidence=ECO:0000255 1585..1688 27/103 (26%)
Spectrin 14. /evidence=ECO:0000255 1690..1793 39/103 (38%)
SPEC 1691..1901 CDD:238103 73/209 (35%)
Spectrin 15. /evidence=ECO:0000255 1797..1899 32/101 (32%)
SPEC 1798..2005 CDD:238103 59/206 (29%)
Spectrin 16. /evidence=ECO:0000255 1906..2006 25/99 (25%)
Spectrin 17. /evidence=ECO:0000255 2013..2075 19/58 (33%)
Spectrin 2013..>2070 CDD:395348 19/56 (34%)
PH_beta_spectrin 2181..2286 CDD:269975
kstNP_001097492.2 CH_beta_spectrin_rpt1 61..176 CDD:409042 66/115 (57%)
CH_beta_spectrin_rpt2 196..302 CDD:409043 65/106 (61%)
SPEC 450..640 CDD:238103 60/195 (31%)
SPEC 658..832 CDD:238103 55/176 (31%)
SH3 885..935 CDD:214620 3/49 (6%)
SPEC 1030..1236 CDD:238103 46/212 (22%)
SPEC 1134..1341 CDD:238103 48/212 (23%)
SPEC 1343..1551 CDD:238103 55/212 (26%)
SPEC 1449..1658 CDD:238103 59/214 (28%)
SPEC 1555..1764 CDD:238103 58/210 (28%)
SPEC 1765..1975 CDD:238103 68/212 (32%)
SPEC 1873..2080 CDD:238103 73/210 (35%)
SPEC 1979..2185 CDD:238103 60/206 (29%)
SPEC 2188..2402 CDD:238103 19/61 (31%)
SPEC 2407..2618 CDD:238103
SPEC 2514..2725 CDD:238103
SPEC 2726..2934 CDD:238103
SPEC 2935..3145 CDD:238103
SPEC 3042..3251 CDD:238103
SPEC 3149..3357 CDD:238103
SPEC 3359..3567 CDD:238103
SPEC 3465..3680 CDD:238103
PH_beta_spectrin 3801..3904 CDD:269975
Blue background indicates that the domain is not in the aligned region.

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