DRSC/TRiP Functional Genomics Resources

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Protein Alignment SPTB and shot

DIOPT Version :10

Sequence 1:NP_001020029.1 Gene:SPTB / 6710 HGNCID:11274 Length:2328 Species:Homo sapiens
Sequence 2:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster


Alignment Length:2041 Identity:443/2041 - (21%)
Similarity:780/2041 - (38%) Gaps:532/2041 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   156 RFQIQDIVVQTQEGRETR-SAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDL 219
            |.:|.||||    |:|.. ||::|||.|.:..||.||.|.|.:|||||:|||||:||:|::||||
  Fly   208 RREISDIVV----GKEDNVSAREALLRWARRSTARYPGVRVNDFTSSWRDGLAFSALVHRNRPDL 268

Human   220 IDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLA 284
            :|:.|.::...|..||.||::.|::.|:..|||||||.|..|||||:|||:.:.|..|.      
  Fly   269 LDWRKARNDRPRERLETAFHIVEKEYGVTRLLDPEDVDTNEPDEKSLITYISSLYDVFP------ 327

Human   285 VEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349
             |...:..:.|  :|:::.:.:|..||...:.|..:....|..|.|..:|..:::.|.....:|:
  Fly   328 -EPPSIHPLFD--MESQRRVHEYRDLAQQFIYWCREKTAYLQERSFPPTLIEMKRLLSDLQRFRS 389

Human   350 VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSD-INRAWESLEEAEYRRELALRNE 413
            .|...:.:||..|..:...::.......:   ...:.:|..| |.:||..:..|...||:.|:.|
  Fly   390 DEVSARKREKSKLIQIYKELERYFETVGE---VDVEAELRPDAIEKAWYRMNTALQDREVILQQE 451

Human   414 LIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERV 478
            :.|.|:|::||.:..|:....:..|::.:..:.::....:......||...||:||:....||.:
  Fly   452 IERLERLQRLADKVQREIKHVDQKLTDLEGRIGEEGRRIERLHPVDAKSIVEALETEIRHLEEPI 516

Human   479 RALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRR-QRL--------ETTLALQKL- 533
            :.:......|.:..|.....:..:.:.:.:.|:.|:....:.. |:|        |||:..|.. 
  Fly   517 QDMNQDCHVLNEGRYPHVSELHKKVNKLHQRWAQLRTNFHTNLVQKLSGLKYPVHETTVTRQTRM 581

Human   534 ------------FQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQK----HKLME-------- 574
                        |:|:...|:|.......||:|::|..|..|::.|.:    ||:::        
  Fly   582 VVESRQIDTNPHFRDLQEHIEWCQNKLKQLLAADYGSDLPSVKEELDRQQHEHKIIDQFHTKILN 646

Human   575 ---ADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQS 636
               ......||::                     .:.|.|::.|::.:.||.:.:..|.:.|:. 
  Fly   647 DERQQTKFSGDEL---------------------ALYQQRLNQLQKVYAELLSTSTKRLSDLDS- 689

Human   637 KRLWKFFWEMDEAESWIKEKEQIYSSLDYGK---DLTSVLILQRKHKAFED---ELRGLDAHLEQ 695
              |..|..:......|:.||||:..:.|:..   ||.||      |:.:|:   ||...:.|...
  Fly   690 --LQHFLGQASAELQWLNEKEQVEITRDWADKQLDLPSV------HRYYENLMSELEKREMHFAT 746

Human   696 IFQEAHGMVARKQFGHPQ---IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKA 757
            |......::.::   ||.   |||.:..:..||..|..|....:.:|:.|..:.||.|:..|.:.
  Fly   747 ILDRGEALLNQQ---HPASKCIEAHLTALQQQWAWLLQLTLCLEVHLKHATEYHQFFGEIKDAEQ 808

Human   758 WLQDAHRLL----SGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG-FPEEFRDSP 817
            ||.....:|    |..|.|.|:|.|...|.  :|..|||......:..|:::||. .|...|..|
  Fly   809 WLAKRDEILNSKFSQSDFGLDQGETLLRGM--QDLREELNAFGETVATLQRRAQTVVPLNKRRQP 871

Human   818 DVTHR--LQALRELYQQVVAQAD---------------------------------LRQQRLQEA 847
             |..:  :||:....||...|.:                                 |.....|||
  Fly   872 -VNRQGPVQAICAYKQQGQLQIEKGETVTLLDNSGRVKWRVRTAKGQEGPIPGACLLLPPPDQEA 935

Human   848 LD----LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQ----HRFDILDQEMKTLMTQI 904
            :|    |..:|..:.|  ||  :|:.......|  ....:.||:    .:|..:..|.:|.:.: 
  Fly   936 IDAAERLKRLFDRSVA--LW--QKKHLRLRQNM--IFATIRVVKGWDFDQFLAMGPEQRTAIRR- 993

Human   905 DGVNLAANSLVESGHPRS---REVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEET 966
             .:|..|:.|:..|.|..   |.:::..|.:|..:..|     |:|...:.         :.::.
  Fly   994 -ALNDDADKLLSEGDPNDPQLRRLRREMDEVNRLFDEF-----EKRARAEE---------ESKQA 1043

Human   967 SKWITDKTKVVES-TKDLGRDLAGIIAIQRKLSGLERDVAAI----------QARVDALERESQQ 1020
            |:..|::...::| .:|:.|:|..||     |:.|.||:.::          :.|:..||.|.:.
  Fly  1044 SRIFTEECLAIKSKLEDMARELDQII-----LAPLPRDLDSLEHVLEIHSDYERRLHLLEPELKH 1103

Human  1021 LMDSH-------PEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLS 1078
            |.::.       |..|:.:    .:|.|||:.|.......:|.|   ..|:|.|..|:|.:..:|
  Fly  1104 LQETFRTIALKTPVLKKSL----DNLMELWKELNTQSGLHKDRL---KLLEASLAGLEDNEHVIS 1161

Human  1079 ITQKAVA-SEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG-- 1140
            ..:..:| .:|:|.:....:|:.:|...::|.|...|....::.::.:::  |:......:||  
  Fly  1162 ELENELARHQDLPSTAEGLQQVFKQLNHMQDIITQQQPQMDKMNDAADQL--GRMGVPTKVLGDL 1224

Human  1141 ----QRLEGLDTGWNALGRMWESRSHTLAQCLG-FQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
                ..:|.|:|.|:|:......|..:....:| .:..|...:..|:.:......|:.:  |.:.
  Fly  1225 KRLHSNVERLNTRWSAVCNQLGERMRSCETAIGLMKNLQSSVQVEESWVDGTTERLSAM--PTAT 1287

Human  1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQ-LIEDR-----HRKN 1259
            .|.|     .:..||:....:.|:.:...:|.:|:.|..:|..|....|. |:|.|     .|::
  Fly  1288 SAYE-----LDKLLGAAIERKPKIENVNVAGGRLIREAKIYDSKCLRFVDWLVEARPSFSPPRRD 1347

Human  1260 NEKA-------QEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQA 1317
            ...|       |..|..| |||..:|     ..|...::.:|.|:.:|:..:.            
  Fly  1348 LRPADSDPGATQYYSQRL-DNLNTKN-----DRLLEQLSQRLKTAIEVNGSDG------------ 1394

Human  1318 FVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSD 1382
                       |:..::..|.|...:..|:|......:......::|..||...|| :|:.:::.
  Fly  1395 -----------LQYAESLQKPLKTFRVDFSAGSVPTGDGYAARQEDLYTTTYSTTQ-ISSTKTTK 1447

Human  1383 LRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVN-----VRKEELG------ 1436
                         |:.:....||  |.|..|.....|.|.:.:.|.|     .|.::||      
  Fly  1448 -------------SSTKSVYSSD--GLDAASQEVSTAGLPQSQIQFNEIRTLKRSQQLGGHSVLD 1497

Human  1437 ------ELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVE 1495
                  ....:|.::||       :|:.|.||:     |..:.|...|                 
  Fly  1498 IAGIRDPRTGRVLTIGE-------AIQLRILDV-----RTGEMLVGDR----------------- 1533

Human  1496 ERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
             |:.|.|:||.|.                                         ||.|..::   
  Fly  1534 -RITLEQAADQGL-----------------------------------------IDLQLAKQ--- 1553

Human  1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
                    |.|..|||               ||...|..:    |.||..||.:.|.|.....||
  Fly  1554 --------LLEPGAGR---------------DASGRELSL----LEVIQREISEAESGYETAEKR 1591

Human  1626 HLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIR---LQGQVDKHYAGLKDVAEERKRKLE 1687
             ::....|     .::|.:.      ..|.||..:.|.   ..|.||.. .||..|...:...|.
  Fly  1592 -IKVNNTV-----TVEQTSG------ELGSPENPRNIADAITAGSVDTK-TGLYRVKSGQTISLA 1643

Human  1688 NMYHL-FQLKRETDDLEQ------------------WISEKELVASSPEMGQDFDHVTLLRDKFR 1733
            ..|.. :.::.|:..::.                  ||:::.                 ..||| 
  Fly  1644 EAYERGYLIRHESVTIKSNALCLSDAIAHGLVDGAGWIADRN-----------------SGDKF- 1690

Human  1734 DFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAE--------WKDG--LNEMWADLLELIDT 1788
               |...||..:.:|   |.:..::||......|:.|        .|.|  :||:..:.|...:.
  Fly  1691 ---RLDSAIANQLID---ASVREVVDAKRDTKITLQEALQSGVLNAKTGRYVNEVTKEKLTFAEA 1749

Human  1789 R-MQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQV 1852
            | .||:...|.|                      :|:                  .:|:||..|.
  Fly  1750 RNRQLIVKPYTL----------------------KDI------------------CDLNLLDKQA 1774

Human  1853 Q----QFQDVATRLQTAYA----GEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTAD-KFRF 1908
            |    ..::..:.:|...|    |...:.|..::.|:....:|:.|.       :|..|: |:|.
  Fly  1775 QITSPMRREKLSIMQAIEAGVLDGNLLKCITKRKGELVTLQEAIADG-------IVLPAECKYRD 1832

Human  1909 FSMARDLLSWMESIIRQIETQERPRDVSSV----ELLMKYHQGINAEIE---TRSKNFSACLELG 1966
            | |..:|:|..|::.|.:.:....|.:..:    :|....:...|..:.   .|.|:....||.|
  Fly  1833 F-MTGELISIPEAVERGLISSVAQRSIFDIDGFKDLRSNDYVSFNVALSRDLLRRKSTGFALETG 1896

Human  1967 -ESLLQRQHQASEE-IREKLQQVMSR 1990
             :||:..:...||. :|:::.::.||
  Fly  1897 RDSLVPLEVAVSEGLVRQEVYEMFSR 1922

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SPTBNP_001020029.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
Actin-binding 2..275 62/119 (52%)
CH_SPTBN2_rpt1 25..156 CDD:409166 443/2041 (22%)
CH_SPTB_rpt2 170..281 CDD:409168 57/111 (51%)
Spectrin 302..412 CDD:395348 23/110 (21%)
Spectrin 1. /evidence=ECO:0000255 303..411 22/108 (20%)
Spectrin 422..525 CDD:395348 18/111 (16%)
Spectrin 2. /evidence=ECO:0000255 423..525 18/110 (16%)
Spectrin 3. /evidence=ECO:0000255 529..635 23/133 (17%)
SPEC 530..742 CDD:238103 51/248 (21%)
Spectrin 4. /evidence=ECO:0000255 638..741 28/111 (25%)
SPEC 641..848 CDD:238103 61/255 (24%)
Spectrin 5. /evidence=ECO:0000255 744..846 31/141 (22%)
SPEC 745..954 CDD:238103 58/259 (22%)
Spectrin 6. /evidence=ECO:0000255 851..950 22/105 (21%)
SPEC 955..1168 CDD:238103 49/237 (21%)
Spectrin 7. /evidence=ECO:0000255 956..1058 25/119 (21%)
Spectrin 8. /evidence=ECO:0000255 1062..1165 23/109 (21%)
SPEC 1170..1379 CDD:238103 42/221 (19%)
Spectrin 9. /evidence=ECO:0000255 1170..1257 18/92 (20%)
Spectrin 10. /evidence=ECO:0000255 1275..1375 15/99 (15%)
SPEC 1385..1475 CDD:197544 21/106 (20%)
Spectrin 11. /evidence=ECO:0000255 1389..1465 20/92 (22%)
Spectrin 12. /evidence=ECO:0000255 1481..1582 14/100 (14%)
SPEC 1485..1690 CDD:238103 39/207 (19%)
Spectrin 13. /evidence=ECO:0000255 1585..1688 25/105 (24%)
Spectrin 14. /evidence=ECO:0000255 1690..1793 23/132 (17%)
SPEC 1691..1901 CDD:238103 38/247 (15%)
Spectrin 15. /evidence=ECO:0000255 1797..1899 15/109 (14%)
SPEC 1798..2005 CDD:238103 39/211 (18%)
Spectrin 16. /evidence=ECO:0000255 1906..2006 22/94 (23%)
Spectrin 17. /evidence=ECO:0000255 2013..2075
Spectrin 2013..>2070 CDD:395348
PH_beta_spectrin 2181..2286 CDD:269975
shotNP_725339.1 SAC6 204..>420 CDD:227401 81/227 (36%)
CH_PLEC-like_rpt2 223..327 CDD:409038 55/103 (53%)
SPEC 471..689 CDD:238103 41/238 (17%)
SPEC 690..866 CDD:238103 51/186 (27%)
SH3_10 864..929 CDD:407754 10/65 (15%)
SPEC 1047..1250 CDD:238103 48/216 (22%)
SPEC 1153..1390 CDD:238103 51/251 (20%)
PLEC <1498..1526 CDD:197605 8/39 (21%)
Plectin 1949..1980 CDD:459901
DUF5585 2860..>3198 CDD:465521
SMC_prok_B <4936..>5564 CDD:274008
SPEC 5304..5513 CDD:238103
SPEC <5658..5787 CDD:413338
SPEC 5793..6007 CDD:238103
SPEC 6011..6220 CDD:238103
SPEC 6118..6330 CDD:238103
PRK09039 <6279..6441 CDD:181619
SPEC 6443..6660 CDD:238103
SPEC 6663..6878 CDD:238103
SPEC 6880..7087 CDD:238103
SPEC 6986..7196 CDD:238103
SPEC 7196..7417 CDD:238103
SPEC 7314..7526 CDD:238103
SPEC 7528..7747 CDD:238103
SPEC 7749..7968 CDD:238103
SPEC 7973..8181 CDD:238103
FRQ1 <8375..8444 CDD:444056
GAS2 8450..8522 CDD:128539
PHA03307 8550..>8795 CDD:223039
Blue background indicates that the domain is not in the aligned region.

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