DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SPTB and beta-Spec

DIOPT Version :10

Sequence 1:NP_001020029.1 Gene:SPTB / 6710 HGNCID:11274 Length:2328 Species:Homo sapiens
Sequence 2:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster


Alignment Length:2340 Identity:1118/2340 - (47%)
Similarity:1542/2340 - (65%) Gaps:74/2340 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    22 RWD---APDD------ELDNDNSSARLFERSRIKALADEREVVQKKTFTKWVNSHLARVSCRITD 77
            |||   .|.:      |.|..|||:||||||||||||:|||.||||||||||||||.||:|||.|
  Fly     9 RWDPSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIAD 73

Human    78 LYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGN 142
            ||.|:|||:.|||||||||||.||||||||||||||||||||||||:||||||||:|||||||||
  Fly    74 LYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGN 138

Human   143 HRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLA 207
            ..|.||||||||||||||||.::..:.:||:|||||||||||||||||.:|||.|||:||:||||
  Fly   139 ASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLA 203

Human   208 FNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVA 272
            |||:||||||||:.|:||..:||.|||.:||:|||.:||:..|||.||||.|:|||||||||||.
  Fly   204 FNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVT 268

Human   273 FYHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGV 337
            :||||||:|...|:|||:|||:..|:|.:||:..|....||||.|||.||..|..|:|.|||.||
  Fly   269 YYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGV 333

Human   338 QQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEA 402
            |.||..||.|||:||||||.|||||||||||:||:|||||||.|||.:||::||||:|||.||:|
  Fly   334 QGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKA 398

Human   403 EYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAI 467
            |:.||||||.||||||||||||.||||||:|||||||||||||:|||||:||||||||.||||||
  Fly   399 EHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAI 463

Human   468 ETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQK 532
            |||..||||||:|:..:..|||.|.|||.|||..||||::|||:||.|||::||.|||.:|.||:
  Fly   464 ETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQ 528

Human   533 LFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF--T 595
            .||:||:.:|.|:|||..|::.::||||:.||||||||.|:||||.|.|::||.:...:.||  .
  Fly   529 NFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSD 593

Human   596 EGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
            :.:.|:||||::|..|:..||..:.||..:|..|:::||:|::||:|:|:..:.|:||||||||.
  Fly   594 DPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIV 658

Human   661 SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQW 725
            |:.:.|.|||:|.::..||||.|.|:...|..|:.:.:....::....||..:|:.|:||:..:|
  Fly   659 STDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKW 723

Human   726 DQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790
            |.|.||..:.::.|::|..:||...||||:..|:.|..|::|.||||:||...::|.|||||..:
  Fly   724 DHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVAD 788

Human   791 ELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFG 855
            ||:....|::.|.:||:.......:..:|..||:|:...|:::...|.||:|||.:||.||.:..
  Fly   789 ELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMS 853

Human   856 ETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
            |.|..|.|:.||.|.|..|.....:||:|:::|||:..|:||....:::..||..|..|:...||
  Fly   854 EADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHP 918

Human   921 RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGR 985
            .|.|:.:.|:|||..|...:.....:.:.:.||..|..:.::|.||..||.||.:::..|..|..
  Fly   919 NSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEM 983

Human   986 DLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSL 1050
            ||.|::.:||:|||::||:|||||::.:||||:..:.|.|||:.:.|.:|...:|.:|:.|.|.|
  Fly   984 DLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQML 1048

Human  1051 QGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQD 1115
            :.::..|.|...|..||:|||.||.||:.||..|||||.|.||||||:||.||..|::|||.:.:
  Fly  1049 KERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTE 1113

Human  1116 SYQRVKESGEKVI-QGQT--DPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDA 1177
            .|:.:.|.||::. :|.|  ||:|:.|.:||..|..||..|.:|||:|...|:|.|..|.|.:||
  Fly  1114 DYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDA 1178

Human  1178 KQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYS 1242
            :|.|.:||.||:.|:..:.|.:||.||..:::.|.||.:||.|.||:.:.:...:.||.:.:..:
  Fly  1179 RQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDA 1243

Human  1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARN 1307
            |||.::.:.|..|...|.::|.:....|::.::|..|||:.:||..|:.:|..||||.||..|:.
  Fly  1244 DKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKT 1308

Human  1308 LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKT 1372
            :|:||.:||||.||:|:::..|...:...::|..|||:|..::..||:.|.:.:|:|:..||||.
  Fly  1309 IHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKG 1373

Human  1373 QHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGE 1437
            ..|..|....|..||..|::.:|:.:|.|:.|.|...||||||.::.|.:.::.|:.|:..::.|
  Fly  1374 AMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEE 1438

Human  1438 LFAQVPSMGEEGGDADL--------SIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWV 1494
            :..|...:.:...:..:        ::.:||..:..||..|:|.||..:...|..||:|||.||:
  Fly  1439 IDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWI 1503

Human  1495 EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERL 1559
            :|:||:|.|.|||.:|..|.:..||||:|..||..|.||:..:...|::|::....|.:..|..:
  Fly  1504 DEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALI 1568

Human  1560 GHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLK 1624
            ..|...|..|::|...|.:.|.::.:.|||:.||.|||:|:.|||||::.::..|||..|..::|
  Fly  1569 SDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMK 1633

Human  1625 RHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENM 1689
            :|...:::||||...|:||...|:.........|:.:...|.|:||.||||||:|.||:.:|...
  Fly  1634 KHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEA 1698

Human  1690 YHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI 1754
            ..||.|.||.|||||||:::|:||.|.|:||||||||||.::|.:|||:|.|:|.|||..||...
  Fly  1699 LQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIA 1763

Human  1755 ERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRE 1819
            :.||.||||::||||||||.|||.|.||||||:||.|:||||.:||::|:...::||.|.||...
  Fly  1764 DNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHG 1828

Human  1820 LPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAA 1884
            :.:::|.||.:..:..|.|..|.::|..|..||||.|:.:.:||.||||:||:.|.|:||||..|
  Fly  1829 VSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHA 1893

Human  1885 WQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGIN 1949
            |..|...|..|:.:|.||.|.||||:|.|.|:.|||.::||:.|.|:|||||.|||||..||.:.
  Fly  1894 WDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLK 1958

Human  1950 AEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQF 2014
            |||:||..||.||:.||:.||.|.|.||.:|:::|..:.:.|..:..:||.|||.|:::|||.||
  Fly  1959 AEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQF 2023

Human  2015 SRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKE- 2078
            :|||:|||||||||||||.|.:.|||:|.||.|||:|||||||.|:..|||:|||:.||.|||| 
  Fly  2024 ARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFELKEM 2088

Human  2079 ---RQIAERPAEETGPQEEEGETAGEAPVSHHAATERTSPGEEEGTWPQNLQQPPPPGQHKDGQK 2140
               :::||....:...:|:|.:.|.||........||....:...:             |.|.. 
  Fly  2089 KRRQELAEEAERQRIKEEQEAKAASEAAEQAKREAERRDDVDVGAS-------------HDDSA- 2139

Human  2141 STGDERPTTEPLFKVLDTPLSEGDEPATLPAPRDHGQSVQMEGYLGRKHDLEGPNKKASNRSWNN 2205
                .:.|.....:|::.....|..|.   |...|      |||:.|||:.:...||||||||:.
  Fly  2140 ----AKDTAVEFERVVEIQTERGGTPG---AGEGH------EGYVTRKHEWDSTTKKASNRSWDK 2191

Human  2206 LYCVLRNSELTFYKDAKNLALG--MPYHGEEPLALRHAICEIAANYKKKKHVFKLRLSNGSEWLF 2268
            :|...:...::||||.|.....  :.:.||....|::|..|||::|.|||||.:::|:||:.:|.
  Fly  2192 VYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKKKHVLRVKLANGALFLL 2256

Human  2269 HGKDEEEMLSWL-----QGVSTAINESQSIRVKAQSLPLPSLSGPDASLGKKDKEKRFSFFPKKK 2328
            ...|:.||..|:     |..|||:..|:|     |:||..|         :||:.||.|||..||
  Fly  2257 QAHDDTEMSQWVTSLKAQSDSTAVAASRS-----QTLPATS---------QKDEPKRRSFFTLKK 2307

Human  2329  2328
              Fly  2308  2307

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SPTBNP_001020029.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 4/16 (25%)
Actin-binding 2..275 195/261 (75%)
CH_SPTBN2_rpt1 25..156 CDD:409166 108/136 (79%)
CH_SPTB_rpt2 170..281 CDD:409168 82/110 (75%)
Spectrin 302..412 CDD:395348 75/109 (69%)
Spectrin 1. /evidence=ECO:0000255 303..411 73/107 (68%)
Spectrin 422..525 CDD:395348 76/102 (75%)
Spectrin 2. /evidence=ECO:0000255 423..525 75/101 (74%)
Spectrin 3. /evidence=ECO:0000255 529..635 49/107 (46%)
SPEC 530..742 CDD:238103 90/213 (42%)
Spectrin 4. /evidence=ECO:0000255 638..741 39/102 (38%)
SPEC 641..848 CDD:238103 77/206 (37%)
Spectrin 5. /evidence=ECO:0000255 744..846 39/101 (39%)
SPEC 745..954 CDD:238103 75/208 (36%)
Spectrin 6. /evidence=ECO:0000255 851..950 32/98 (33%)
SPEC 955..1168 CDD:238103 96/215 (45%)
Spectrin 7. /evidence=ECO:0000255 956..1058 40/101 (40%)
Spectrin 8. /evidence=ECO:0000255 1062..1165 52/105 (50%)
SPEC 1170..1379 CDD:238103 75/208 (36%)
Spectrin 9. /evidence=ECO:0000255 1170..1257 31/86 (36%)
Spectrin 10. /evidence=ECO:0000255 1275..1375 40/99 (40%)
SPEC 1385..1475 CDD:197544 25/97 (26%)
Spectrin 11. /evidence=ECO:0000255 1389..1465 19/83 (23%)
Spectrin 12. /evidence=ECO:0000255 1481..1582 38/100 (38%)
SPEC 1485..1690 CDD:238103 80/204 (39%)
Spectrin 13. /evidence=ECO:0000255 1585..1688 43/102 (42%)
Spectrin 14. /evidence=ECO:0000255 1690..1793 66/102 (65%)
SPEC 1691..1901 CDD:238103 111/209 (53%)
Spectrin 15. /evidence=ECO:0000255 1797..1899 40/101 (40%)
SPEC 1798..2005 CDD:238103 95/206 (46%)
Spectrin 16. /evidence=ECO:0000255 1906..2006 51/99 (52%)
Spectrin 17. /evidence=ECO:0000255 2013..2075 44/61 (72%)
Spectrin 2013..>2070 CDD:395348 41/56 (73%)
PH_beta_spectrin 2181..2286 CDD:269975 43/111 (39%)
beta-SpecNP_001259660.1 CH_SPTB-like_rpt1 36..152 CDD:409095 100/115 (87%)
CH_SPTB_like_rpt2 169..273 CDD:409097 76/103 (74%)
Spectrin 298..408 CDD:395348 75/109 (69%)
SPEC 422..521 CDD:197544 73/98 (74%)
SPEC 525..740 CDD:238103 90/214 (42%)
SPEC 639..846 CDD:238103 77/206 (37%)
SPEC 848..1058 CDD:238103 76/209 (36%)
SPEC 955..1169 CDD:238103 95/213 (45%)
SPEC 1170..1380 CDD:238103 75/209 (36%)
SPEC 1386..1484 CDD:197544 25/97 (26%)
SPEC 1488..1699 CDD:238103 81/210 (39%)
SPEC 1594..1806 CDD:238103 112/211 (53%)
SPEC 1807..2015 CDD:238103 95/207 (46%)
Spectrin 2018..>2078 CDD:395348 43/59 (73%)
PH_beta_spectrin 2167..2274 CDD:269975 42/112 (38%)

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