DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf128 and H10E21.5

DIOPT Version :9

Sequence 1:	NP_075759.3	Gene:	Rnf128 / 66889	MGIID:	1914139	Length:	428	Species:	Mus musculus
Sequence 2:	NP_497129.1	Gene:	H10E21.5 / 175169	WormBaseID:	WBGene00019185	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	247	Identity:	78/247 - (31%)
Similarity:	125/247 - (50%)	Gaps:	31/247 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse   207 SIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGKLQLRTLKQG-DKEI 270
            |:.|||:||.|:...::.:.:||..:|.|.|.|:.|.||:|...|:||:.::...|:..| .:|:
Worm   159 SVLFVSISFIILMVISLAWLVFYYVQRFRYAHAKDRLQRRLFNAARKALTRIPTMTITPGMTQEL 223

Mouse   271 GPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDV---- 331
            ..|   ||||::.|:..|::|:|.|.||:||:|:||||||||||||||.||||..|...|:
Worm   224 QSD---CAVCLDPYQLQDVIRLLPCKHIYHKSCIDPWLLEHRTCPMCKNDILKHFGYWNDIRNDI 285

Mouse   332 ----------EDGSVSLQVPVSNEASNTASPHEEDSRSETASSGYASVQGADEPPLEEHAQSANE 386
                      :|.::.|::......:.:|.....::.|:|:.|...|...::....|......:.
Worm   286 QMPTNSRGIADDFTIRLELGEQEHQAPSADVISPEANSDTSDSQGFSFDNSEHHHSESFGYGTSS 350

Mouse   387 NL--QLVNHEAN---------SVAVDVVPHVDNPTFEEDETP-DQEAAVREI 426
            .:  |||.:.:|         |..|...|.... .|.....| |..|::.|:
Worm   351 TVPPQLVLNASNAKSFVMPLSSRGVSQGPQASR-DFRSARAPRDHRASLHEL 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf128	NP_075759.3	PA_GRAIL_like	48..193	CDD:239037
		zf-RING_2	275..318	CDD:290367	26/42 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..428		18/97 (19%)
H10E21.5	NP_497129.1	HRD1	<150..325	CDD:227568	62/168 (37%)
H10E21.5	NP_497129.1	RING-H2_GRAIL	226..273	CDD:319582	31/49 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I5750
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm16989
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.970