Protein Alignment SPG7 and AFG3

DIOPT Version :9

• Sequence 1: NP_001350779.1
• Gene: SPG7 / 6687
• HGNCID: 11237
• Length: 809
• Species: Homo sapiens
• Sequence 2: NP_010933.1
• Gene: AFG3 / 856737
• SGDID: S000000819
• Length: 761
• Species: Saccharomyces cerevisiae
• Alignment Length: 755
• Identity: 302/755 - (40%)
• Similarity: 438/755 - (58%)
• Gaps: 82/755 - (10%)

Human     5 LLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRALQSLQLRLLT 69
            :::.:...||   .||.|    .:.|.|..:|....:|.:.||.|             :..||.|
Yeast     1 MMMWQRYARG---APRSL----TSLSFGKASRISTVKPVLRSRMP-------------VHQRLQT 45

Human    70 PTFEGINGLLLKQHLVQN-PVRLWQLLGGTFYFNTSRLKQK--NKE--------KDKSKGKAPEE 123
                 ::||..:..:.:: .:|       :|:.:.:||.:.  |||        ||.:..|   |
Yeast    46 -----LSGLATRNTIHRSTQIR-------SFHISWTRLNENRPNKEGEGKNNGNKDNNSNK---E 95

Human   124 DEEERRRRERDDQMY---RERLRTLLV---IAVVMSLLNALSTSGGS-----ISWNDFVHEMLAK 177
            |.:::|........|   :|...|:.:   ..::.:||...|.:.|.     :::.||..:.|.|
Yeast    96 DGKDKRNEFGSLSEYFRSKEFANTMFLTIGFTIIFTLLTPSSNNSGDDSNRVLTFQDFKTKYLEK 160

Human   178 GEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIP 242
            |.|.::.||.:..|....::...||          ...:.::|.|||::...:|.|||..:||||
Yeast   161 GLVSKIYVVNKFLVEAELVNTKQVV----------SFTIGSVDIFEEQMDQIQDLLNIPPRDRIP 215

Human   243 VSY-KRTGFFGNALYSVGMTAVGLAILWYVFRLAGMT------GREGGFSAFNQLKMARFTIVDG 300
            :.| :|:..| ..|:....|.:.|..|:::.|....:      |..||......:..:|..:.:.
Yeast   216 IKYIERSSPF-TFLFPFLPTIILLGGLYFITRKINSSPPNANGGGGGGLGGMFNVGKSRAKLFNK 279

Human   301 KMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATE 365
            :....:|||:|||..|||.|:.|||.:||:|.::.:||||:|:||:|.||||.||||||||.|.|
Yeast   280 ETDIKISFKNVAGCDEAKQEIMEFVHFLKNPGKYTKLGAKIPRGAILSGPPGTGKTLLAKATAGE 344

Human   366 AQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMS-GFSNTEE 429
            |.||||:::|.||||:..|:||:|||.||.:||:.||.|::||||||:||:|....: |.:|.|.
Yeast   345 ANVPFLSVSGSEFVEMFVGVGASRVRDLFTQARSMAPSIIFIDEIDAIGKERGKGGALGGANDER 409

Human   430 EQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQERREIFEQHLK 494
            |.|||||||||||..|:|.|:|||.|||.|:||.|||||||.|||:.||.|.:..|::|:..|||
Yeast   410 EATLNQLLVEMDGFTTSDQVVVLAGTNRPDVLDNALMRPGRFDRHIQIDSPDVNGRQQIYLVHLK 474

Human   495 SLK----LTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLNFEYAVERVLAG 555
            .|.    ||......|.:||.|||||:||||||.||||||.|||.....:...:||.|:|||:||
Yeast   475 RLNLDPLLTDDMNNLSGKLATLTPGFTGADIANACNEAALIAARHNDPYITIHHFEQAIERVIAG 539

Human   556 TAKKSKILSKEEQKVVAFHESGHALVGWMLEHTEAVMKVSITPRTNAALGFAQMLPRDQHLFTKE 620
            ..||:::|||||::.||:||:|||:.||.|::.:.::||||.||...|||:||.||.||:|.::|
Yeast   540 LEKKTRVLSKEEKRSVAYHEAGHAVCGWFLKYADPLLKVSIIPRGQGALGYAQYLPPDQYLISEE 604

Human   621 QLFERMCMALGGRASEALSFNEVTSGAQDDLRKVTRIAYSMVKQFGMAPGIGPISFPEAQEGLMG 685
            |...||.||||||.||.|.|..|||||.||.:|||::|.:||...||:|.||.:|| :..:|...
Yeast   605 QFRHRMIMALGGRVSEELHFPSVTSGAHDDFKKVTQMANAMVTSLGMSPKIGYLSF-DQNDGNFK 668

Human   686 IGRRPFSQGLQQMMDHEARLLVAKAYRHTEKVLQDNLDKL 725
            : .:|||....:.:|.|.:.:|..|:|...::|..||||:
Yeast   669 V-NKPFSNKTARTIDLEVKSIVDDAHRACTELLTKNLDKV 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPG7	NP_001350779.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..133		9/34 (26%)
		FtsH_ext	145..242	CDD:310823	25/104 (24%)
		TIP49	265..729	CDD:332389	237/472 (50%)
AFG3	NP_010933.1	FtsH_ext	124..215	CDD:377663	25/100 (25%)
		FtsH_fam	223..730	CDD:273520	240/488 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010