DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPG7 and spg7

DIOPT Version :9

Sequence 1:	NP_001350779.1	Gene:	SPG7 / 6687	HGNCID:	11237	Length:	809	Species:	Homo sapiens
Sequence 2:	XP_001923118.1	Gene:	spg7 / 794740	ZFINID:	ZDB-GENE-030131-5391	Length:	788	Species:	Danio rerio

Alignment Length:	705	Identity:	550/705 - (78%)
Similarity:	619/705 - (87%)	Gaps:	15/705 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    61 QSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKAPEEDE 125
            |.:..:.|.|...|:. ...:.:|:....:||:|||.|.||:||..|.:||:  ..|||.|||:|
Zfish    55 QDILTKPLIPRLIGLE-FHCRHNLLTTQAKLWKLLGSTHYFSTSNRKHENKQ--GGKGKTPEEEE 116

Human   126 EERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESD 190
            ||::|||::|||||||||||.:|||:|||||:::||||:|||||||:||||||||.|||||||||
Zfish   117 EEKKRREQEDQMYRERLRTLFIIAVIMSLLNSINTSGGNISWNDFVNEMLAKGEVSRVQVVPESD 181

Human   191 VVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNAL 255
            :||:|||||||:||||||||||||||||||||||||||||:||||:|||||||:|||||||||||
Zfish   182 IVEIYLHPGAVIFGRPRLALMYRMQVANIDKFEEKLRAAEEELNIDAKDRIPVTYKRTGFFGNAL 246

Human   256 YSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLE 320
            |::||.|:|:|||||:||||||.||:||||||||||||:|||||||.||||||||||||.|||:|
Zfish   247 YALGMAAIGVAILWYIFRLAGMGGRDGGFSAFNQLKMAKFTIVDGKSGKGVSFKDVAGMREAKME 311

Human   321 VREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGL 385
            |:|||||||:|:|:||||||||||:||||||||||||||||||||||||||||||.|||||||||
Zfish   312 VKEFVDYLKNPDRYLQLGAKVPKGSLLLGPPGCGKTLLAKAVATEAQVPFLAMAGSEFVEVIGGL 376

Human   386 GAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVI 450
            ||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||
Zfish   377 GAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTNMSGFSNTEEEQTLNQLLVEMDGMGTTDHVI 441

Human   451 VLASTNRADILDGALMRPGRLDRHVFIDLPTLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPG 515
            ||||||||||||.|||||||||||:||||||||||:||||||||.|||||.:.|||.||||||||
Zfish   442 VLASTNRADILDNALMRPGRLDRHIFIDLPTLQERKEIFEQHLKILKLTQPADFYSLRLAELTPG 506

Human   516 FSGADIANICNEAALHAAREGHTSVHTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHESGHAL 580
            |||||||||||||||||||||..|:.|.:||||||||:||:.|||||||||||:|||||||||||
Zfish   507 FSGADIANICNEAALHAAREGFKSIDTFSFEYAVERVIAGSVKKSKILSKEEQRVVAFHESGHAL 571

Human   581 VGWMLEHTEAVMKVSITPRTNAALGFAQMLPRDQHLFTKEQLFERMCMALGGRASEALSFNEVTS 645
            |||:||||||||||||.|||||||||||:|||||.||||||||||||||||||||||::||:||:
Zfish   572 VGWLLEHTEAVMKVSIAPRTNAALGFAQILPRDQFLFTKEQLFERMCMALGGRASEAITFNKVTT 636

Human   646 GAQDDLRKVTRIAYSMVKQFGMAPGIGPISFPEAQEGLMGIGRRPFSQGLQQMMDHEARLLVAKA 710
            |||||||||||:|||||||:||...:|.:|||:: |...|||||||||||||.||.||::|:|||
Zfish   637 GAQDDLRKVTRVAYSMVKQYGMVDSVGQVSFPDS-ENQSGIGRRPFSQGLQQQMDLEAKMLIAKA 700

Human   711 YRHTEKVLQDNLDK--LQARAL----CVTWG---SCLGPLDCRPQPAAAASGQVW 756
            ||||||:|.||.||  |.|.||    .|.:.   :.|||....|:...|.  |.|
Zfish   701 YRHTEKLLLDNRDKLILLANALLEREVVNYNDIEALLGPPPFGPKRMIAP--QSW 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPG7	NP_001350779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..133		13/24 (54%)
		FtsH_ext	145..242	CDD:310823	82/96 (85%)
		TIP49	265..729	CDD:332389	399/465 (86%)
spg7	XP_001923118.1	FtsH_ext	136..233	CDD:284011	82/96 (85%)
		FtsH_fam	257..738	CDD:273520	402/481 (84%)
		AAA	337..470	CDD:278434	128/132 (97%)
		Peptidase_M41	552..736	CDD:279742	138/184 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	298	1.000	Domainoid score	I7538
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31133
Inparanoid	1	1.050	1161	1.000	Inparanoid score	I1732
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48979
OrthoDB	1	1.010	-	-		D109623at7742
OrthoFinder	1	1.000	-	-		FOG0005483
OrthoInspector	1	1.000	-	-		otm27701
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR43655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3185
SonicParanoid	1	1.000	-	-		X4433
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.610