DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPG7 and yta12

DIOPT Version :9

Sequence 1:	NP_001350779.1	Gene:	SPG7 / 6687	HGNCID:	11237	Length:	809	Species:	Homo sapiens
Sequence 2:	NP_596797.1	Gene:	yta12 / 2541079	PomBaseID:	SPBC543.09	Length:	773	Species:	Schizosaccharomyces pombe

Alignment Length:	712	Identity:	294/712 - (41%)
Similarity:	419/712 - (58%)	Gaps:	57/712 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    58 RALQSLQLRLLTPTFEGINGLLLKQHLV-----QNPVRLWQLLGGTFYFNTSRLKQKNKEK-DKS 116
            |:.|||::....|....|..:..||..|     ||         |:...|:....:||.:| |.|
pombe    58 RSFQSLKINKGIPEKHKIPLISSKQFSVTSKRSQN---------GSSGSNSDANGRKNGQKNDDS 113

Human   117 KGKAPEEDEEERRRRERDDQMYRERL--RTLL-VIAVVMSLLNALSTSGG--SISWNDFVHEMLA 176
            |.|....::.::        ::...|  .|:| .|.|...|.|.||.:..  .|:|.||..:.|.
pombe   114 KKKGLNGNDPKK--------VFEIALNGNTILGGILVAYILYNVLSPNANMQEITWQDFRQQFLD 170

Human   177 KGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRI 241
            ||.|:|: ||...::|.|.|. |.|..|..:    |...:.:||.|:.||..|:.:|.|...:.:
pombe   171 KGLVERL-VVVNRNMVRVILR-GGVASGSGQ----YYFSIGSIDSFDRKLEDAQRQLGIPPSEFV 229

Human   242 PVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLA-GMTGREGGFSAFNQLKMARFTIVDGKMGKG 305
            ||:|.........|.|...|.:.:..:.|:.|.| |..|  ||......:..:|..:.:.:....
pombe   230 PVAYHDEVSVLATLLSFAPTLLIIGSVIYLSRRASGAAG--GGQGGIFGIGKSRAKMFNHETDIK 292

Human   306 VSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPF 370
            :.|.||||:.|||.|:.|||.:||:|:.:.:||||:|:||:|.||||.||||||||.|.||.|||
pombe   293 IKFADVAGVDEAKEEIMEFVKFLKNPKFYERLGAKIPRGAILSGPPGTGKTLLAKATAGEANVPF 357

Human   371 LAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQ 435
            |:::|.||:|:..|:|.:|||.||..||..||||::||||||:||.|.......||.|.|.||||
pombe   358 LSVSGSEFLEMFVGVGPSRVRDLFATARKNAPCIIFIDEIDAIGKARGRGGQFGSNDERESTLNQ 422

Human   436 LLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQERREIFEQHLKSLKLTQ 500
            |||||||..:::|::|.|.|||.|:||.||:||||.||.:.||.|.:..|.:||:.|||.:|...
pombe   423 LLVEMDGFTSSEHIVVFAGTNRPDVLDPALLRPGRFDRQITIDRPDIGGREQIFKVHLKHIKAAD 487

Human   501 SSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLNFEYAVERVLAGTAKKSKILSK 565
            :....::|||.||.||:||||.|:|||.||.|||.....|..::||.|:|||.||..|||::||.
pombe   488 NIDLIAKRLAVLTSGFTGADIMNVCNEGALIAARSNSNEVQMVHFEQAIERVTAGLEKKSRVLSP 552

Human   566 EEQKVVAFHESGHALVGWMLEHTEAVMKVSITPRTNAALGFAQMLPRDQHLFTKEQLFERMCMAL 630
            ||:..||.||:|||:.||.:|:.:.::||||.||.. |||:|..||:||:|.::.|:.::|.|||
pombe   553 EEKNTVAHHEAGHAVAGWFMEYVDPLLKVSIIPRAQ-ALGYASYLPKDQYLMSRGQILDQMGMAL 616

Human   631 GGRASEALSF--NEVTSGAQDDLRKVTRIAYSMVKQFGMAPGIGPISFP-EAQEGLMGIGRRPFS 692
            .||.||.:.|  .::||||.||.:||||:|.:.|.|:||:|.:|.|::| :.:|.:    ::|||
pombe   617 AGRVSEEIFFGPEKITSGASDDFQKVTRMAQAYVTQYGMSPTVGTIAYPIDTRETV----QKPFS 677

Human   693 QGLQQMMDHEARLLVAKAYRHTEKVL---QDNLDKLQARAL---CVTWG---SCLGPLDCRP 745
            :...||:|.|.|.||..||..|:|:|   :..|:.:..|.|   .:|:.   :.|||   ||
pombe   678 EATAQMIDEEIRKLVKHAYERTKKLLLEHKQGLENIAQRLLQKEVITYNEVETILGP---RP 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPG7	NP_001350779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..133		7/25 (28%)
		FtsH_ext	145..242	CDD:310823	33/99 (33%)
		TIP49	265..729	CDD:332389	225/470 (48%)
yta12	NP_596797.1	FtsH_ext	136..230	CDD:284011	33/99 (33%)
		FtsH_fam	238..733	CDD:273520	231/501 (46%)
		AAA	333..466	CDD:278434	79/132 (60%)
		Peptidase_M41	548..731	CDD:279742	78/187 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010