DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPG7 and ppgn-1

DIOPT Version :9

Sequence 1:	NP_001350779.1	Gene:	SPG7 / 6687	HGNCID:	11237	Length:	809	Species:	Homo sapiens
Sequence 2:	NP_500191.3	Gene:	ppgn-1 / 177021	WormBaseID:	WBGene00021425	Length:	747	Species:	Caenorhabditis elegans

Alignment Length:	736	Identity:	333/736 - (45%)
Similarity:	463/736 - (62%)	Gaps:	104/736 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    33 FPARPGRGRPYMASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGG 97
            ||.|    ||   :||..:.:||                             .::|.:.|:
Worm    40 FPQR----RP---ARPKEESSEA-----------------------------EKSPPKRWE---- 64

Human    98 TFYFNTSRLKQKNKEKDKSKGKAPEEDEEERRRRERDD---QMYRERLRTLLVIAV-------VM 152
               |..| ...|...:.||..|:..|..|.....:.|:   :...|:::..|.|::       ::
Worm    65 ---FEIS-WSSKGHRETKSDAKSASEGNENGGGNKGDNDPRKQLMEKMKRWLAISLFAYGILFIL 125

Human   153 SLLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLH-PGAVVFGRPRLALMYRMQV 216
            |...|.:.:...|||::|::|:|..|:|.|:.::||.||..:|.: .||......:||.|||:.:
Worm   126 SPKGAAAVTADKISWSEFINELLPTGQVYRIIILPEKDVAYLYCYDTGAKNSRGEKLASMYRVGI 190

Human   217 ANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWY-VFRLAGMTGR 280
            .::.:||.::||||..|.:..:....:.|:|:.....               |: :..|.|:.
Worm   191 PSVARFETEVRAAEAALGLPPEHWTQIEYRRSENVAQ---------------WFTIIVLGGLL-- 238

Human   281 EGGFSAFNQLK-------------MARFTIVD-----GKMGKGVSFKDVAGMHEAKLEVREFVDY 327
            .|||..|.:.|             ..:|||:|     ||....:.||||||..|||:|:||||||
Worm   239 LGGFVLFRKFKGSFNMSDMMSNMTKGKFTIIDPHSVEGKKQLKIKFKDVAGCSEAKVEIREFVDY 303

Human   328 LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRS 392
            ||:|.||.:||||:|:||||.|||||||||||||:|.|:.|||::|.|.|||||||||||:|:|.
Worm   304 LKNPGRFTKLGAKLPRGALLTGPPGCGKTLLAKALAAESTVPFISMNGSEFVEVIGGLGASRIRG 368

Human   393 LFKEARARAPCIVYIDEIDAVGKKRSTTMS-----GFSNTEEEQTLNQLLVEMDGMGTTDHVIVL 452
            ||||||:|||||:|||||||:|:|||....     |..:.|||||||||||||||||:.:.|:||
Worm   369 LFKEARSRAPCIIYIDEIDAIGRKRSEGAGAGGGFGGGSGEEEQTLNQLLVEMDGMGSGNGVVVL 433

Human   453 ASTNRADILDGALMRPGRLDRHVFIDLPTLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFS 517
            |||||||:||.||:||||.|||:.|||||:.||:::||.:::.:||..:...||||||.|||||:
Worm   434 ASTNRADVLDKALLRPGRFDRHISIDLPTVLERKDMFELYMRKIKLDHAPQEYSQRLAALTPGFT 498

Human   518 GADIANICNEAALHAA-REGHTSVHTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHESGHALV 581
            ||||.|:|||:|:.|| .:.|...|. :.|||::|||||:.|:|:.|.:||::|||:||:|||||
Worm   499 GADIMNVCNESAIRAASNKCHVVTHK-DMEYALDRVLAGSEKRSRSLVEEEREVVAYHEAGHALV 562

Human   582 GWMLEHTEAVMKVSITPRTNAALGFAQMLPRDQHLFTKEQLFERMCMALGGRASEALSFNEVTSG 646
            |||||||:|::||:|.|||:|||||||..|||:|||:|::||:||||.||||.:|.|.|...|||
Worm   563 GWMLEHTDALLKVTIIPRTSAALGFAQYSPRDKHLFSKDELFDRMCMMLGGRCAENLKFGRATSG 627

Human   647 AQDDLRKVTRIAYSMVKQFGMAPGIGPISFPEAQEGLMGIGRRPFSQGLQQMMDHEARLLVAKAY 711
            |||||:|||:.||:.||.:||:..:||:|||..:    |...:|:|:......|.||.|:||||.
Worm   628 AQDDLQKVTKSAYAQVKLYGMSSIVGPLSFPNTE----GFQIKPYSKKFASTFDQEATLIVAKAN 688

Human   712 RHTEKVLQDNLDKLQ--ARAL 730
            ..|..::::|:|||:  |:||
Worm   689 EATTDLIKNNMDKLETIAQAL 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPG7	NP_001350779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..133		6/24 (25%)
		FtsH_ext	145..242	CDD:310823	32/104 (31%)
		TIP49	265..729	CDD:332389	276/490 (56%)
ppgn-1	NP_500191.3	FtsH_ext	111..212	CDD:377663	32/100 (32%)
ppgn-1	NP_500191.3	FtsH_fam	277..725	CDD:273520	265/438 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	215	1.000	Domainoid score	I1728
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31133
Inparanoid	1	1.050	619	1.000	Inparanoid score	I524
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48979
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	1	1.000	-	-		FOG0005483
OrthoInspector	1	1.000	-	-		oto21815
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR43655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3185
SonicParanoid	1	1.000	-	-		X4433
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.110