Protein Alignment SPAST and Spast

DIOPT Version :10

• Sequence 1: NP_055761.2
• Gene: SPAST / 6683
• HGNCID: 11233
• Length: 616
• Species: Homo sapiens
• Sequence 2: XP_008762708.1
• Gene: Spast / 362700
• RGDID: 1308494
• Length: 614
• Species: Rattus norvegicus
• Alignment Length: 616
• Identity: 577/616 - (93%)
• Similarity: 586/616 - (95%)
• Gaps: 2/616 - (0%)

Human     1 MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLR 65
            |:||.||.||||||||| |.|.|||||...|| |||||||.|.||||||||||||||.|||||||
  Rat     1 MSSPAGRRKKKGSGGAS-PAPARPPPPAAVPA-PAAGPAPAPGSPHKRNLYYFSYPLVVGFALLR 63

Human    66 LVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIA 130
            |:|.|||||||||||||||||||||||||.||||||.|.|||.||||||.|||||||||||||||
  Rat    64 LLACHLGLLFVWLCQRFSRALMAAKRSSGTAPAPASPSTPAPGPGGEAESVRVFHKQAFEYISIA 128

Human   131 LRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAKMMTNLVMAKDRLQLL 195
            |||||:||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||
  Rat   129 LRIDEEEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQYERARRLQAKMMTNLVMAKDRLQLL 193

Human   196 EKMQPVLPFSKSQTDVYNDSTNLACRNGHLQSESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGL 260
            ||:||||.||||||||||:||||.|||||||||||||||:||||||.||||||||||||:||.||
  Rat   194 EKLQPVLQFSKSQTDVYNESTNLTCRNGHLQSESGAVPKKKDPLTHASNSLPRSKTVMKSGSTGL 258

Human   261 SGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSNLA 325
            ||||||||.||||||||.:.|||||.||||||.|.||||||||||||.|||||||||||||||||
  Rat   259 SGHHRAPSCSGLSMVSGARPGSGPAATTHKGTSKPNRTNKPSTPTTAVRKKKDLKNFRNVDSNLA 323

Human   326 NLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTM 390
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
  Rat   324 NLIMNEIVDNGTAVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTM 388

Human   391 LAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEH 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   389 LAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEH 453

Human   456 DASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKN 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   454 DASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKN 518

Human   521 LLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDF 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   519 LLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDF 583

Human   586 TESLKKIKRSVSPQTLEAYIRWNKDFGDTTV 616
            |||||||||||||||||||||||||||||||
  Rat   584 TESLKKIKRSVSPQTLEAYIRWNKDFGDTTV 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPAST	NP_055761.2	Required for interaction with RTN1. /evidence=ECO:0000269|PubMed:16602018	1..300		261/298 (88%)
		Required for midbody localization. /evidence=ECO:0000269|PubMed:18997780	1..194		170/192 (89%)
		Required for interaction with ATL1. /evidence=ECO:0000269|PubMed:16339213, ECO:0000269|PubMed:16815977	1..80		63/78 (81%)
		Required for nuclear localization. /evidence=ECO:0000269|PubMed:15147984	1..50		36/48 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43		30/41 (73%)
		Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:15147984	4..11		4/6 (67%)
		Required for interaction with SSNA1 and microtubules. /evidence=ECO:0000269|PubMed:15269182	50..87		33/36 (92%)
		Nuclear export signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:16026783	59..67		7/7 (100%)
		Sufficient for interaction with CHMP1B. /evidence=ECO:0000269|PubMed:18997780	112..196		80/83 (96%)
		Required for interaction with microtubules. /evidence=ECO:0000269|PubMed:15269182	114..200		81/85 (95%)
		MIT_spastin	116..195	CDD:239142	76/78 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	224..266		37/41 (90%)
		Sufficient for microtubule severing. /evidence=ECO:0000269|PubMed:15269182	228..616		374/387 (97%)
		Required for interaction with microtubules and microtubule severing. /evidence=ECO:0000269|PubMed:15269182	270..328		50/57 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	278..312		26/33 (79%)
		Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:15147984	309..312		2/2 (100%)
		Required for interaction with microtubules. /evidence=ECO:0000269|PubMed:23272056	310..312		1/1 (100%)
		RecA-like_spastin	343..506	CDD:410932	161/162 (99%)
		AAA_lid_3	533..587	CDD:465537	53/53 (100%)
		Vps4_C	<580..612	CDD:462762	31/31 (100%)
Spast	XP_008762708.1	MIT_spastin	114..193	CDD:239142	76/78 (97%)
		RecA-like_spastin	341..504	CDD:410932	161/162 (99%)
		AAA_lid_3	531..585	CDD:465537	53/53 (100%)
		Vps4_C	<578..610	CDD:462762	31/31 (100%)