DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP4 and Spps

DIOPT Version :9

Sequence 1:	NP_003103.2	Gene:	SP4 / 6671	HGNCID:	11209	Length:	784	Species:	Homo sapiens
Sequence 2:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster

Alignment Length:	903	Identity:	261/903 - (28%)
Similarity:	358/903 - (39%)	Gaps:	289/903 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   100 NAWQLVASTPPASKENNVSQPASSSSSSSSS---NNGSASPTKTK-SGNSSTPGQFQVIQV-QNP 159
            :|.....|.|||:       |.::..||.::   |..||:.::|: .|...||...|:|.: |.|
  Fly     6 SAASAATSAPPAT-------PLAAGGSSKATIPPNGASAAASQTQVHGAPGTPTMQQIINIHQMP 63

Human   160 --------SGSVQYQVIPQ-----LQTVEGQQIQINPTSSSSLQDLQGQI---QLISAGNNQAIL 208
                    :|:.|...:||     :|.:..|.:.|:...:..:.:|..|:   |.::....||.:
  Fly    64 PQFAGGAVAGNGQNAGMPQNMFQIVQPMPMQTVNIDGQEAIFIPNLNAQLATAQAVNFNGQQAFI 128

Human   209 T-----------AANRTASGNILAQNL----ANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTT-- 256
            |           |||..||..|..|.|    ..||             ||.|:|||..|:..|
  Fly   129 TPNGQILRAPQMAANPAASNCIQLQQLNGLGQEQT-------------QLITIPGTNIQIPVTNL 180

Human   257 ----------------------------------------LP--INIGGVTLALPVINNVAAGGG 279
                                                    ||  |.|.|..|.:|  .:|||..|
  Fly   181 IQQQQQAQQVHQGTVQQQAQGTNASGANGSGVTNSGTAGQLPGSITIPGTNLQIP--TSVAAANG 243

Human   280 -TGQVGQPAATADSGTS----NGN-----QLVSTPTNTTTSASTMPESPSSSTTCTTTASTSLTS 334
             .|.:...:.....|.|    ||.     |||..|.         |..|....|..........:
  Fly   244 LLGNISNISNLLGGGQSIKLENGQLQMRPQLVQFPA---------PAMPQQQQTVAVQIPVQTAN 299

Human   335 SDTLVSSADTGQYASTSASSSERTIEESQT---PAATESE-----AQSSSQLQPNGMQNAQDQSN 391
            ..|:..:......|:.::|...:.:.::|:   |:|::.:     :|.:..:.|||
  Fly   300 GQTIYQTVHVPVQAAATSSGGLQNLMQAQSLQMPSASQMQIIPQFSQIAQIVTPNG--------- 355

Human   392 SLQQVQIVG-----QPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQ------ 445
            .:||||:..     .|....|.||.|.||..|.:..|..|.|:.|..|..|||..|..|
  Fly   356 QIQQVQLAMPYPQLPPNANIIHIQNPHQQQQQQVQQQQQQQQAQQQQQAQQQQAQQQQQQQVQAQ 420

Human   446 ----LQAVN---------------------------PTQVLIRAPTL---------TPSGQISWQ 470
                |||::                           |.|:...|||.         ||....:.|
  Fly   421 HQQLLQAISDASAGGQLPPNQPITITNAQGQQLTVIPAQLRPNAPTAPTPAPAGVPTPMQMPNLQ 485

Human   471 TVQVQNIQSLSNLQVQN---------AGLSQQLTITPVSSSGGTTLAQI---------------- 510
            .:.:|||..|..:|:.:         |...|.||..|:|.....|..|:
  Fly   486 ALPIQNIPGLGQVQIIHANQLPPNLPANFQQVLTQLPMSHPQVQTQGQVQVMPKQEPQSPTQMIT 550

Human   511 ----------APVAVAGAP----ITLNTA--QLASVPNLQTV--SVANLG-AAGVQVQGVPVTIT 556
                      .|::..|.|    .|.|||  |...:..|.|.  |:::|. .|.:|:..:|...|
  Fly   551 SIKQEPPDTFGPISATGNPPAPASTPNTASPQQQQIKFLHTESNSLSSLSIPASIQITALPQQAT 615

Human   557 SVAGQQQGQDGVKVQ---------------QATIAP-------VTVAVGGIANATIGAVSPDQLT 599
            :..........:.|.               |.||||       ||....| |.|:|.:.:....|
  Fly   616 NTPNTPATTQPIPVSLPARSKVNAVTTSSTQITIAPTGGQVVSVTTQARG-ATASIRSTNTSTTT 679

Human   600 -----QVHLQQ--------------GQQTSDQEVQPGKRLRRVACSCPNCREGEGRGSNEPGKKK 645
                 |.||..              |..|:..|.:|  ||:||||:||||.:||    ....||:
  Fly   680 ITTPSQSHLNMNISVASVGGAATGGGGGTATGEPKP--RLKRVACTCPNCTDGE----KHSDKKR 738

Human   646 QHICHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKRFECP 710
            ||||||.||.||||||||||||||||||||||:|:|.|||||||||||||||||||||||||:|.
  Fly   739 QHICHITGCHKVYGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQ 803

Human   711 ECSKRFMRSDHLSKHVKTHQNKKGGGTALAI-----VTSGELDSSVTEVLGSPRIVTV 763
            ||:|:||||||||||:|||...:.|...:.:     ...|....|::.|.|   |||:
  Fly   804 ECNKKFMRSDHLSKHIKTHFKSRSGVELIELSIKQETKGGNAPKSISTVNG---IVTI 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP4	NP_003103.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..150		13/44 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..390		22/125 (18%)
		9aaTAD, inactive. /evidence=ECO:0000269\|PubMed:31375868	467..475		1/7 (14%)
		zf-C2H2	647..671	CDD:333835	21/23 (91%)
		C2H2 Zn finger	649..671	CDD:275368	19/21 (90%)
		zf-C2H2	677..701	CDD:333835	20/23 (87%)
		C2H2 Zn finger	679..701	CDD:275368	19/21 (90%)
		zf-H2C2_2	693..716	CDD:372612	19/22 (86%)
		zf-C2H2	707..729	CDD:333835	16/21 (76%)
		C2H2 Zn finger	709..729	CDD:275368	15/19 (79%)
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	81/105 (77%)
		C2H2 Zn finger	742..764	CDD:275368	19/21 (90%)
		zf-H2C2_2	756..783	CDD:290200	23/26 (88%)
		C2H2 Zn finger	772..794	CDD:275368	19/21 (90%)
		zf-H2C2_2	786..809	CDD:290200	19/22 (86%)
		zf-C2H2	800..822	CDD:278523	16/21 (76%)
		C2H2 Zn finger	802..822	CDD:275368	15/19 (79%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9785
eggNOG	1	0.900	-	-		E33208_3BGI1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3329
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1085860at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41988
orthoMCL	1	0.900	-	-		OOG6_109416
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.870