DRSC/TRiP Functional Genomics Resources

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Protein Alignment SP3 and pad

DIOPT Version :10

Sequence 1:NP_003102.1 Gene:SP3 / 6670 HGNCID:11208 Length:781 Species:Homo sapiens
Sequence 2:NP_650534.2 Gene:pad / 41981 FlyBaseID:FBgn0038418 Length:924 Species:Drosophila melanogaster


Alignment Length:757 Identity:173/757 - (22%)
Similarity:268/757 - (35%) Gaps:194/757 - (25%)


- Green bases have known domain annotations that are detailed below.


Human     4 PEKPVKQEEMAALDVDSGGGGGGGGGHGEYLQQQQQHGNGAVAAAAAAQDTQPSPLALLAATCSK 68
            ||..:|.|...||:              |:::.:              .|.:.:||       .|
  Fly   169 PEVQIKSERQTALE--------------EFIRLK--------------PDIKITPL-------GK 198

Human    69 IGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQLGGAPNRWEVLSATPT------TIKDEAGNLV 127
            ..|.||...:::                          :..:..:.|||      .::.:.|:.:
  Fly   199 KEPISPAKPQQQ--------------------------HSLQSQTVTPTINPTQLQLQPQLGDQL 237

Human   128 QIPSAATSSGQYVLPLQNLQNQ----QIFSVAPGSDSSNGTVSSVQYQVIPQIQSADGQQVQIGF 188
            |.........|....||.|.||    ..:|||....||:|.....:...:  :.|....|    |
  Fly   238 QPLWQQIQQLQLQQQLQQLTNQLQATTQYSVAQDDTSSSGDSKKPKLNFV--LSSPTAPQ----F 296

Human   189 TGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVV 253
            |.|....|.:|...|:|::|||.....|...|:           |.|:...|: .||..| .|..
  Fly   297 TTSMPQFGGSQPQIQLQLMPGSGGVTSAGTVPA-----------QTQLNAAAL-LSSLAG-PQST 348

Human   254 ANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSP 318
            .|:   |..|..|:||...|      ..|.|.:.|.|:....::.|         :.:...::.|
  Fly   349 TNL---LSPNKCFLPITIRD------ENSDQQIVAHIDTKNLVLPT---------TYQVQMKLQP 395

Human   319 DINETNTDTDL-FVPTSSSSQLPVTIDSTGILQQNTNSLTTSSGQVHSSDLQGNYIQSPVSEETQ 382
            .:...:....: ..|||    :|.|      ||....:|.........:.:..|...:|....||
  Fly   396 QLATADGQPIMQLTPTS----IPAT------LQLTPQTLGNPGSAFQGTTVTQNQFLAPQQPLTQ 450

Human   383 AQNIQVSTAQPVVQ--HLQLQESQ--------------QPTSQAQIVQGITP------------Q 419
            ..|....|:|.:::  |.....||              .|||..:.....||            :
  Fly   451 LPNTAQVTSQQIIRSPHTSTTNSQLVIRNVTNIPPTPTTPTSSKKAPTFKTPSPKQKPMPSPKSK 515

Human   420 TIHGVQASGQN-ISQQALQNLQLQLNPGTFLIQAQT--VTPSGQVTWQTFQVQGVQNLQNLQIQN 481
            |..|..:.|.| .|....:.|..|..|...:.|.||  ::.||..|..:.....:|.|.:    |
  Fly   516 TTVGPSSGGSNGTSTNEFKRLITQTKPQPQVKQQQTAGLSASGAPTATSANQAAMQRLSS----N 576

Human   482 TAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSID---SAGIQLHPGENAD 543
            |.   ||..|.|..:|...|.    ||.|..|   .:.|.|.:|::.|.   :...|..|...:.
  Fly   577 TT---ITKVPKQPASLPAPAP----TSNPAKL---PMLNKQNITISRISMQTAPKAQSKPSTTSP 631

Human   544 SPADIRI-------KEEEPDPEEWQLSGDSTLNTNDLTHLR-VQVVDEEGDQQHQEGKRLRRVAC 600
            :||...|       .:.:|.|...|             |.: |:...|..|...|:.|..|....
  Fly   632 TPASQPIPVSVPALSQAQPPPLAAQ-------------HKKIVRKPPENQDTSGQKVKAARPPQQ 683

Human   601 TCPNCKEGGGRGTNLGKKKQH----ICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKR 661
            ..|:.::.|...|:.|.:...    ||  |.|.:.:.|..||..|::.|:|.|||.|:...|.|.
  Fly   684 ILPSPQQEGQNATHSGSEAPTTSGLIC--PTCKREFKKKEHLTQHVKLHAGLRPFKCSEEGCDKT 746

Human   662 FTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTH 703
            |:|.:.|.||..:|:|:|.:.|..|.|.|.|.|:|.||.:.|
  Fly   747 FSRKEHLSRHLVSHSGQKMYTCEVCKKPFSRKDNLNKHRRIH 788

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP3NP_003102.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..53 7/48 (15%)
SP3_N 52..622 CDD:411774 132/626 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 65..88 4/22 (18%)
Transactivation domain (Gln-rich) 138..237 28/102 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 301..338 4/37 (11%)
Transactivation domain (Gln-rich) 350..499 40/179 (22%)
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 461..469 1/7 (14%)
Repressor domain 534..620 19/93 (20%)
zf-C2H2 621..645 CDD:395048 8/27 (30%)
C2H2 Zn finger 623..645 CDD:275368 7/21 (33%)
zf-C2H2 651..675 CDD:395048 9/23 (39%)
C2H2 Zn finger 653..675 CDD:275368 8/21 (38%)
zf-H2C2_2 667..690 CDD:463886 9/22 (41%)
zf-C2H2 681..703 CDD:395048 9/21 (43%)
C2H2 Zn finger 683..703 CDD:275368 9/19 (47%)
padNP_650534.2 zf-AD 16..88 CDD:462262
PHA03247 <497..709 CDD:223021 53/238 (22%)
C2H2 Zn finger 710..730 CDD:275368 7/21 (33%)
zf-C2H2 736..760 CDD:395048 9/23 (39%)
C2H2 Zn finger 738..760 CDD:275368 8/21 (38%)
zf-C2H2 766..788 CDD:395048 9/21 (43%)
C2H2 Zn finger 768..788 CDD:275368 9/19 (47%)
zf-C2H2 797..819 CDD:395048
C2H2 Zn finger 799..819 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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