DRSC/TRiP Functional Genomics Resources

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Protein Alignment SP3 and btd

DIOPT Version :9

Sequence 1:NP_003102.1 Gene:SP3 / 6670 HGNCID:11208 Length:781 Species:Homo sapiens
Sequence 2:NP_511100.1 Gene:btd / 31912 FlyBaseID:FBgn0000233 Length:644 Species:Drosophila melanogaster


Alignment Length:515 Identity:147/515 - (28%)
Similarity:196/515 - (38%) Gaps:161/515 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   367 DLQGNYIQSPVSEETQAQNIQVST----AQPVVQHLQLQESQ------QPTSQAQIVQGITPQTI 421
            |...||: :|.:::.|||..|.:.    ||....||.:|::|      ...:|.|.:|.:|.|  
  Fly     3 DAACNYL-NPYAQQHQAQQQQHAQHQQHAQQQQHHLHMQQAQHHLHLSHQQAQQQHMQHLTQQ-- 64

Human   422 HGVQASGQNISQQALQNLQLQLNP----GTFLIQAQTVT-------------------------- 456
               |...|...||..|..|.|..|    ..||..|..::                          
  Fly    65 ---QQQQQQQQQQQQQQQQQQQQPQQQQHDFLSAAALLSAPPSLSGSSSGSSSGSSPLYGKPPMK 126

Human   457 -----PSGQVTWQTFQVQGVQNLQNL-----QIQNTAAQQIT------LTPVQTLTLGQVAAGGA 505
                 |....|........:|:..:.     .|..:.||...      .||..||.....||.||
  Fly   127 LELPYPQASSTGTASPNSSIQSAPSSASVSPSIFPSPAQSFASISASPSTPTTTLAPPTTAAAGA 191

Human   506 FTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADS------------PADIR--------- 549
            ...:|.|.|.............:..:|...|.....|.:            ||..:         
  Fly   192 LAGSPTSSSPSSSAASAAAAAAAAAAAAADLGAAAVASAAYGWNTAYSGLGPARSQFPYAQYASD 256

Human   550 --------------IKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVAC 600
                          ...:|...:.|........|.:|:.              .|...:.|.|.|
  Fly   257 YYGNAVGMSSSAAWFSHQERLYQPWSSQSYPGFNFDDIA--------------FQTQLQRRSVRC 307

Human   601 TCPNC-KEGGGRGTNLGK----KKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGK 660
            ||||| .|..|....:|.    :||||||||||.::|||.|||:.|||||:|||||:|  :.|||
  Fly   308 TCPNCTNEMSGLPPIVGPDERGRKQHICHIPGCERLYGKASHLKTHLRWHTGERPFLC--LTCGK 370

Human   661 RFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTH-QNKKGIHSSSTVLAS------ 718
            ||:||||||||.||||..:.:.||.|||:|.|||||:||.||| ::||    |..|||:      
  Fly   371 RFSRSDELQRHGRTHTNYRPYACPICSKKFSRSDHLSKHKKTHFKDKK----SKKVLAAEAKEQA 431

Human   719 --------------------VEAARD--DTLITAGGTTLI----LANIQQGSVSGIGTVN 752
                                ||..::  ||      |.|:    .||:.|.|.|...:||
  Fly   432 AAAIKLEKKEKKSGKPLTPPVEFKQEQPDT------TPLVNYAPYANLYQHSTSAGSSVN 485

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP3NP_003102.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..53
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 65..88
Transactivation domain (Gln-rich) 138..237
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 301..338
Transactivation domain (Gln-rich) 350..499 40/187 (21%)
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 461..469 1/7 (14%)
Repressor domain 534..620 20/125 (16%)
C2H2 Zn finger 623..645 CDD:275368 15/21 (71%)
COG5048 <636..718 CDD:227381 52/82 (63%)
zf-H2C2_2 637..664 CDD:290200 18/26 (69%)
C2H2 Zn finger 653..675 CDD:275368 15/21 (71%)
zf-H2C2_2 667..690 CDD:290200 14/22 (64%)
zf-C2H2 681..703 CDD:278523 14/21 (67%)
C2H2 Zn finger 683..703 CDD:275368 14/19 (74%)
btdNP_511100.1 C2H2 Zn finger 338..357 CDD:275368 12/18 (67%)
zf-H2C2_2 349..374 CDD:290200 18/26 (69%)
C2H2 Zn finger 365..385 CDD:275368 15/21 (71%)
zf-H2C2_2 377..402 CDD:290200 15/24 (63%)
zf-C2H2 391..413 CDD:278523 14/21 (67%)
C2H2 Zn finger 393..413 CDD:275368 14/19 (74%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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