Protein Alignment DST and AGA1

DIOPT Version :10

• Sequence 1: NP_001361665.1
• Gene: DST / 667
• HGNCID: 1090
• Length: 7818
• Species: Homo sapiens
• Sequence 2: NP_014442.1
• Gene: AGA1 / 855780
• SGDID: S000005327
• Length: 725
• Species: Saccharomyces cerevisiae
• Alignment Length: 397
• Identity: 86/397 - (21%)
• Similarity: 132/397 - (33%)
• Gaps: 58/397 - (14%)

Human  1527 IQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY-----SATVKDYELQTMTYRAM 1586
            :....|.::...:|..:....|.|.|....:.:.........|     |:.|....:.:.|....
Yeast   307 LASTSPSSTSISSTFTDSTSSLGSSIASSSTSVSLYSPSTPVYSVPSTSSNVATPSMTSSTVETT 371

Human  1587 VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1651
            |.||..|....:   ||....|..| .:.|.:|.:..:.|.|..:...|    .|.|.|......
Yeast   372 VSSQSSSEYITK---SSISTTIPSF-SMSTYFTTVSGVTTMYTTWCPYS----SESETSTLTSMH 428

Human  1652 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDK 1716
            |.|           ....|:...|.......:....||.::|||....|.:..|::...|    .
Yeast   429 ETV-----------TTDATVCTHESCMPSQTTSLITSSIKMSTKNVATSVSTSTVESSYA----C 478

Human  1717 MTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAG----TIDQTTGEV 1777
            .|..|.:.....|:|...|.....:.|.|....|.|:.|    |..:|...|    |...|:...
Yeast   479 STCAETSHSYSSVQTASSSSVTQQTTSTKSWVSSMTTSD----EDFNKHATGKYHVTSSGTSTIS 539

Human  1778 LSVFQAVLRGLIDYDT---GIRLLETQLMISGLISPELRKCFD---LKDAKSHGLIDEQILCQLK 1836
            .||.:|.....||.::   ...||.|.::.|..:|..|..  |   |..:....|..||......
Yeast   540 TSVSEATSTSSIDSESQEQSSHLLSTSVLSSSSLSATLSS--DSTILLFSSVSSLSVEQSPVTTL 602

Human  1837 ELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNL 1901
            ::|...||:...|.|.|..:.|...|              ||..|:..|:|..:.|::.:.....
Yeast   603 QISSTSEILQPTSSTAIATISASTSS--------------LSATSISTPSTSVESTIESSSLTPT 653

Human  1902 VSSALFS 1908
            |||...|
Yeast   654 VSSIFLS 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DST	NP_001361665.1	CH_SF	201..358	CDD:469584
		CH_DYST_rpt2	363..466	CDD:409088
		SPEC	819..910	CDD:197544
		SPEC	912..1094	CDD:238103
		SH3_10	1087..1153	CDD:407754
		Spectrin_like	1188..1265	CDD:465730
		SCP-1	<1205..1480	CDD:114219
		SPEC	1405..1569	CDD:413338	5/41 (12%)
		PLEC	1763..1794	CDD:197605	9/37 (24%)
		Plectin	1872..1909	CDD:459901	10/37 (27%)
		Plectin	1986..2024	CDD:459901
		Plectin	2062..2100	CDD:459901
		SCP-1	3445..4110	CDD:114219
		SMC_prok_B	<3824..4606	CDD:274008
		SPEC	4135..4364	CDD:238103
		SPEC	4725..4946	CDD:238103
		SPEC	4951..5165	CDD:238103
		SPEC	5167..5378	CDD:238103
		SPEC	5493..5708	CDD:238103
		SPEC	5607..5820	CDD:238103
		SPEC	5714..5929	CDD:238103
		SPEC	5931..6146	CDD:238103
		SPEC	6042..6255	CDD:238103
		SPEC	6152..6368	CDD:238103
		SPEC	6370..6587	CDD:238103
		SPEC	6482..6696	CDD:238103
		SPEC	6590..6805	CDD:238103
		SPEC	6698..6914	CDD:238103
		SPEC	6916..7132	CDD:238103
		SPEC	7029..7241	CDD:238103
		FRQ1	<7412..7475	CDD:444056
		GAS2	7487..7562	CDD:128539
AGA1	NP_014442.1	None