DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP2 and Spps

DIOPT Version :9

Sequence 1:	XP_011523438.1	Gene:	SP2 / 6668	HGNCID:	11207	Length:	771	Species:	Homo sapiens
Sequence 2:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster

Alignment Length:	910	Identity:	234/910 - (25%)
Similarity:	334/910 - (36%)	Gaps:	311/910 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   123 YLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPP----APPQPTPRKLVPIKPAPLPLSP 183
            |...|::.|.....:|||...::.:.|.|....||.:..    ||..||.::::.|...|...:.
  Fly     4 YKSAASAATSAPPATPLAAGGSSKATIPPNGASAAASQTQVHGAPGTPTMQQIINIHQMPPQFAG 68

Human   184 GKNSFGILSSKGNILQIQGSQLSASYPGGQLVFAIQNP----TMINKGTRS----NANIQY---Q 237
            |              .:.|:..:|..|  |.:|.|..|    |:...|..:    |.|.|.   |
  Fly    69 G--------------AVAGNGQNAGMP--QNMFQIVQPMPMQTVNIDGQEAIFIPNLNAQLATAQ 117

Human   238 AV----------PQIQASNSQTIQVQPNLTNQIQI---------------IPGTNQAIITPS--P 275
            ||          |..|...:..:...|..:|.||:               |||||..|...:  .
  Fly   118 AVNFNGQQAFITPNGQILRAPQMAANPAASNCIQLQQLNGLGQEQTQLITIPGTNIQIPVTNLIQ 182

Human   276 SSHKPVPIKPAPIQKSSTTTTPVQSGANVVKLTGGG------GNVT-----LTLP---------- 319
            ...:...:....:|:.:..|.  .||||...:|..|      |::|     |.:|
  Fly   183 QQQQAQQVHQGTVQQQAQGTN--ASGANGSGVTNSGTAGQLPGSITIPGTNLQIPTSVAAANGLL 245

Human   320 --VNNLVNASDTGAPTQL----LTESP-----PTPLSKTNKKARKKSLPASQPPVAVAEQVETVL 373
              ::|:.|....|...:|    |...|     |.|           ::|..|..|||...|:|..
  Fly   246 GNISNISNLLGGGQSIKLENGQLQMRPQLVQFPAP-----------AMPQQQQTVAVQIPVQTAN 299

Human   374 IETTADNI---IQAG-------NNLLIVQS---PGGGQPAV----------------VQQVQV-- 407
            .:|....:   :||.       .||:..||   |...|..:                :||||:
  Fly   300 GQTIYQTVHVPVQAAATSSGGLQNLMQAQSLQMPSASQMQIIPQFSQIAQIVTPNGQIQQVQLAM 364

Human   408 ----VPPKA---------------------------------------EQQQVVQIPQQALRVVQ 429
                :||.|                                       :||||....||.|:.:.
  Fly   365 PYPQLPPNANIIHIQNPHQQQQQQVQQQQQQQQAQQQQQAQQQQAQQQQQQQVQAQHQQLLQAIS 429

Human   430 AASA--TLP-----TVPQKPSQNFQIQAAE--------PTPTQVYIRTPS--------------- 464
            .|||  .||     |:.....|...:..|:        |||....:.||.
  Fly   430 DASAGGQLPPNQPITITNAQGQQLTVIPAQLRPNAPTAPTPAPAGVPTPMQMPNLQALPIQNIPG 494

Human   465 -GEVQTVLVQDSPPATAAATSNTTCSSPASR-----------APHLSGTSKKHSAAILRKE---- 513
             |:||.:.....||...|.........|.|.           .|.....|.......:::|
  Fly   495 LGQVQIIHANQLPPNLPANFQQVLTQLPMSHPQVQTQGQVQVMPKQEPQSPTQMITSIKQEPPDT 559

Human   514 ---------RPLPKIAP----------------AGSIISLN---AAQLAA-AAQAMQTIN----- 544
                     .|.|...|                :.|:.||:   :.|:.| ..||..|.|
  Fly   560 FGPISATGNPPAPASTPNTASPQQQQIKFLHTESNSLSSLSIPASIQITALPQQATNTPNTPATT 624

Human   545 ------------INGVQVQGVPVTITNTGGQ--------QQLTVQNVSGNNLTISGLSPTQIQLQ 589
                        :|.|......:||..||||        :..|....|.|..|.:..:|:|..|.
  Fly   625 QPIPVSLPARSKVNAVTTSSTQITIAPTGGQVVSVTTQARGATASIRSTNTSTTTITTPSQSHLN 689

Human   590 MEQALA----------GETQPGEKR---RRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFR 641
            |..::|          |.|..||.:   :|:|||||||.||||.|.:  |::|:|||..|.|.:.
  Fly   690 MNISVASVGGAATGGGGGTATGEPKPRLKRVACTCPNCTDGEKHSDK--KRQHICHITGCHKVYG 752

Human   642 KTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTK 706
            |||.||||:|.|||||||||:|.|||||||||||||||.|||||:|||:|.:|.|:|||||||:|
  Fly   753 KTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSK 817

Human   707 HYKTHLVTKN------FCLRQNLQLGSSASFVFSLGEL-------------GEGTPEEGAVVSQS 752
            |.|||..:::      ..::|..:.|::...:.::..:             |.|.....|.|:.|
  Fly   818 HIKTHFKSRSGVELIELSIKQETKGGNAPKSISTVNGIVTIEIPGGGSAAAGSGASSVAATVAGS 882

Human 753 752
Fly 883 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP2	XP_011523438.1	COG5048	<553..718	CDD:227381	95/191 (50%)
		zf-C2H2	629..653	CDD:278523	14/23 (61%)
		C2H2 Zn finger	634..653	CDD:275368	10/18 (56%)
		zf-H2C2_2	646..672	CDD:290200	21/25 (84%)
		C2H2 Zn finger	661..683	CDD:275368	18/21 (86%)
		zf-H2C2_2	675..698	CDD:290200	16/22 (73%)
		zf-C2H2	689..711	CDD:278523	14/21 (67%)
		C2H2 Zn finger	691..711	CDD:275368	13/19 (68%)
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	71/103 (69%)
		C2H2 Zn finger	742..764	CDD:275368	13/21 (62%)
		zf-H2C2_2	756..783	CDD:290200	21/26 (81%)
		C2H2 Zn finger	772..794	CDD:275368	18/21 (86%)
		zf-H2C2_2	786..809	CDD:290200	16/22 (73%)
		zf-C2H2	800..822	CDD:278523	14/21 (67%)
		C2H2 Zn finger	802..822	CDD:275368	13/19 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9785
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1085860at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.020