DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP2 and sr

DIOPT Version :9

Sequence 1:	XP_011523438.1	Gene:	SP2 / 6668	HGNCID:	11207	Length:	771	Species:	Homo sapiens
Sequence 2:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster

Alignment Length:	891	Identity:	163/891 - (18%)
Similarity:	247/891 - (27%)	Gaps:	379/891 - (42%)

- Green bases have known domain annotations that are detailed below.

Human   109 QTSMAATAAVSPS--DYLQPA-------------------ASTTQDSQPSPLALLAATCSKIGPP 152
            :||.||.::.|||  .||.||                   :||...|..|...|...|.|.....
  Fly   319 KTSTAAQSSGSPSTATYLSPAQFGGSHHGGASTSSNSLNSSSTASSSSTSSSLLHYTTASAAAAA 383

Human   153 AVEAAVT-----------PPAPPQPTPRKLVPIKPAPLPLSPGKNSFGILSSKGNILQIQGSQLS 206
            |..||.:           ...|.|......|.::|: ...|.|::|              .|.||
  Fly   384 AAAAAASANNSVLRARNQTATPTQGGSPGHVAVQPS-ATASSGRSS--------------ASHLS 433

Human   207 ASYPGGQLVFAIQNPTMINKGTRSNANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIPGTNQAII 271
            .....||     .:||.             .||.|::|..           ..|:.:||.....:
  Fly   434 LLNTSGQ-----HSPTS-------------SAVEQVEAHK-----------QLIEALPGDLNTPV 469

Human   272 TPS---PSSHKPVPIKPAPIQKSSTTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNASDTGAPT 333
            |.|   ||...|..:...|                               |:...:.:.|.....
  Fly   470 TTSSDIPSFFGPTTVVEPP-------------------------------PITGSIESEDLSLEP 503

Human   334 QLLTESPPTPLSKTNKKARKKSLPASQPPVAVAEQVE---------------------TVLIETT 377
            |:::.:.|. ||..:....::|.|   |.:|:.::..                     |....||
  Fly   504 QVISVASPV-LSHCSPLKEERSTP---PALAIVKEESSNNSCNMYPQHNNNNNNNNNTTSSSTTT 564

Human   378 ADNIIQAGNNLLIVQSPGG---------------------------------------------- 396
            ......:.:|...|.|||.
  Fly   565 TSKQTTSESNTECVGSPGNHTQSHQQQQQQLQHNNTSSSNSNCHHSHQQQQQQQQQQHMSSPQQQ 629

Human   397 -GQPAVVQQVQVVP---------------------PKAEQQQVVQIPQQALRVVQ---------- 429
             .|..::.|.|.:|                     .:.:|||..|..||.|...|
  Fly   630 YQQHQILHQQQQLPNHHHHHHHHHHHHSQLQQLQQQQQQQQQQQQHQQQPLHQQQQLQHQQQQQH 694

Human   430 -------------------------------------AASATLPTVPQKPSQNFQIQAAEPTPTQ 457
                                                 ||:|......|:..|..|.|...|:|..
  Fly   695 HQQHYQQHAIQHQQSQQQASKISYRGIFTTTGNAMNAAAAAAAAAAQQQHQQQQQHQQQLPSPQL 759

Human   458 VYIRTPSGEVQTVLVQDSPPATAAATS-------NTTCSSPASRAPHLSGTSKKHSAAILRKERP 515
            ..:..|.          |||:.:...|       .|....|....|....|.::......::::.
  Fly   760 GVLAGPM----------SPPSNSLGNSWGLPSPDKTMFQPPLFSLPAHYATMQQQQQQQQQQQQQ 814

Human   516 LPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTI-------------------TNTG 561
            ..:...||:..|......||||.|.|...:.|:.:...|:.:                   .::.
  Fly   815 QQQQQAAGAAPSPYDDGRAAAAAAAQHAELLGLTMDCTPLLLKQPPPSYAGASAGFPGLGDLHSS 879

Human   562 GQQQLTVQNVSGNNLTISGL-SPT----------QIQLQMEQ----ALAGETQPGE--------- 602
            .:|||..|....:......| ||.          |:|.|.:|    .|.|.|....
  Fly   880 HEQQLQQQQYVRSQPKYQWLDSPADYAQQQQQVQQVQQQQQQQQTLVLPGPTSSASSSNAALGVL 944

Human   603 --KRRRMACTCPNCKDGEKRSGEQG---------------------------------------- 625
              |:.......|: .:|...||..|
  Fly   945 IPKQENYPDMQPS-SNGTGYSGGSGGSSAAAAAAAAAAAAAVQLAEYSPSTSKGHEILSQVYQQS 1008

Human   626 ------------------------KKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFC 666
                                    ::.:.|.:.:|.:.|.::..|..|:|:|||::||.|.  .|
  Fly  1009 TVPLKLVPVKPRKYPNRPSKTPVHERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCR--IC 1071

Human   667 GKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHL 712
            .:.|:|||.|..|.|||||:|.|.|..|.::|.|||...:|.|.||
  Fly  1072 MRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHL 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP2	XP_011523438.1	COG5048	<553..718	CDD:227381	57/269 (21%)
		zf-C2H2	629..653	CDD:278523	6/23 (26%)
		C2H2 Zn finger	634..653	CDD:275368	5/18 (28%)
		zf-H2C2_2	646..672	CDD:290200	11/25 (44%)
		C2H2 Zn finger	661..683	CDD:275368	9/21 (43%)
		zf-H2C2_2	675..698	CDD:290200	11/22 (50%)
		zf-C2H2	689..711	CDD:278523	9/21 (43%)
		C2H2 Zn finger	691..711	CDD:275368	8/19 (42%)
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	6/23 (26%)
		C2H2 Zn finger	1038..1060	CDD:275368	6/21 (29%)
		zf-H2C2_2	1052..1077	CDD:290200	11/26 (42%)
		C2H2 Zn finger	1068..1088	CDD:275368	9/21 (43%)
		zf-H2C2_2	1080..1105	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1096..1116	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030