Protein Alignment SP1 and Spps

DIOPT Version :10

• Sequence 1: NP_612482.2
• Gene: SP1 / 6667
• HGNCID: 11205
• Length: 785
• Species: Homo sapiens
• Sequence 2: NP_001262902.1
• Gene: Spps / 42882
• FlyBaseID: FBgn0039169
• Length: 985
• Species: Drosophila melanogaster
• Alignment Length: 862
• Identity: 257/862 - (29%)
• Similarity: 349/862 - (40%)
• Gaps: 183/862 - (21%)

Human    28 NGNGGGAF---------------SQARSSSTGSSSSTGGGGQESQPSPLALLAATCSRIESPNEN 77
            |.||..||               :.|.|:........|.|.:::|     |:....:.|:.|..|
  Fly   120 NFNGQQAFITPNGQILRAPQMAANPAASNCIQLQQLNGLGQEQTQ-----LITIPGTNIQIPVTN 179

Human    78 SNNSQGPSQS--GGTGELDLTATQLSQGANGWQIISS-SSGATPTSKEQSG---------SSTNG 130
            ....|..:|.  .||.:.....|..| ||||..:.:| ::|..|.|....|         ::.||
  Fly   180 LIQQQQQAQQVHQGTVQQQAQGTNAS-GANGSGVTNSGTAGQLPGSITIPGTNLQIPTSVAAANG 243

Human   131 SNGSESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPG-VMPNIQYQVIPQF--QTVDGQQL----- 187
            ..|:.|:.:..:.|||.:......||.:..|...|. .||..|..|..|.  ||.:||.:
  Fly   244 LLGNISNISNLLGGGQSIKLENGQLQMRPQLVQFPAPAMPQQQQTVAVQIPVQTANGQTIYQTVH 308

Human   188 ---QFAATGA----------QVQQDGSGQIQIIPGANQ--QIITNRGSGGNIIAAMP-------- 229
               |.|||.:          .:|...:.|:||||..:|  ||:|..|....:..|||
  Fly   309 VPVQAAATSSGGLQNLMQAQSLQMPSASQMQIIPQFSQIAQIVTPNGQIQQVQLAMPYPQLPPNA 373

Human   230 NLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQES 294
            |::....|.|.....|...|.|.......................|......||::.:|:|.|..
  Fly   374 NIIHIQNPHQQQQQQVQQQQQQQQAQQQQQAQQQQAQQQQQQQVQAQHQQLLQAISDASAGGQLP 438

Human   295 GSQPVTSGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNM--GIMNFTTSGSSGTNSQGQTPQ 357
            .:||:|                    .|||.....|...:.:  ......|...:|.    .||.
  Fly   439 PNQPIT--------------------ITNAQGQQLTVIPAQLRPNAPTAPTPAPAGV----PTPM 479

Human   358 RVSGLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQQTQQQQILIQ-----PQLVQGGQALQALQA 417
            ::..||   ||.| ||....|.:|.....:...|.....||:|.|     ||:...||    :|.
  Fly   480 QMPNLQ---ALPI-QNIPGLGQVQIIHANQLPPNLPANFQQVLTQLPMSHPQVQTQGQ----VQV 536

Human   418 APLSGQTFTTQ---AISQETLQNLQLQAVPNSGPIIIRTP-TVGPNGQ----VSWQTLQLQNLQV 474
            .|.......||   :|.||........:...:.|....|| |..|..|    :..::..|.:|.:
  Fly   537 MPKQEPQSPTQMITSIKQEPPDTFGPISATGNPPAPASTPNTASPQQQQIKFLHTESNSLSSLSI 601

Human   475 QNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPA----GTVTVNAAQLSSMP-GLQTINL 534
              |.:..||..|.|.     |::.||..|......|:||    ..||.::.|::..| |.|.:::
  Fly   602 --PASIQITALPQQA-----TNTPNTPATTQPIPVSLPARSKVNAVTTSSTQITIAPTGGQVVSV 659

Human   535 S--ALGTSGIQVHPIQGLPLAIANAPGDH------GAQLGLHGAGGDGIHDDTAGGEEGENSPDA 591
            :  |.|.:. .:.........|......|      .|.:|....||.|      |...||..|
  Fly   660 TTQARGATA-SIRSTNTSTTTITTPSQSHLNMNISVASVGGAATGGGG------GTATGEPKP-- 715

Human   592 QPQAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPF 656
                  |.:|.|||||.|.|.|....    ||:||||||.||.||||||||||||||||||||||
  Fly   716 ------RLKRVACTCPNCTDGEKHSD----KKRQHICHITGCHKVYGKTSHLRAHLRWHTGERPF 770

Human   657 MCTWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTH------------- 708
            :|:|::||||||||||||||:|||||||:|.|.||.|:||||||||||||||
  Fly   771 VCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRSGVELIELS 835

Human   709 --QNKKGG---PGVALSVGTLPLD-SGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGI 767
              |..|||   ..::...|.:.:: .|.||..:|:...|...|   ||...:.|.|..
  Fly   836 IKQETKGGNAPKSISTVNGIVTIEIPGGGSAAAGSGASSVAAT---VAGSTVTPGGAT------- 890

Human   768 NVMQVADLQSINISGNG 784
                :..|.::..||.|
  Fly   891 ----IVQLPTVEASGGG 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1	NP_612482.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..93		18/81 (22%)
		Repressor domain	2..82		14/68 (21%)
		SP1_N	54..627	CDD:411775	158/643 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..141		9/41 (22%)
		Transactivation domain A (Gln-rich)	146..251		37/135 (27%)
		Transactivation domain B (Gln-rich)	261..495		55/248 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	329..395		15/67 (22%)
		9aaTAD. /evidence=ECO:0000269|PubMed:31375868	462..470		0/7 (0%)
		Transactivation domain C (highly charged)	496..610		32/126 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	567..598		7/30 (23%)
		VZV IE62-binding	619..785		93/185 (50%)
		zf-C2H2	626..650	CDD:395048	21/23 (91%)
		C2H2 Zn finger	628..650	CDD:275368	19/21 (90%)
		zf-H2C2_2	642..669	CDD:463886	22/26 (85%)
		C2H2 Zn finger	658..680	CDD:275368	17/21 (81%)
		zf-H2C2_2	672..695	CDD:463886	17/22 (77%)
		zf-C2H2	686..708	CDD:395048	17/21 (81%)
		C2H2 Zn finger	688..708	CDD:275368	16/19 (84%)
		Domain D	708..785		20/96 (21%)
Spps	NP_001262902.1	SP1-4_N	<281..>371	CDD:425404	27/89 (30%)
		Atrophin-1	284..>630	CDD:460830	90/384 (23%)
		SP1-4_N	<713..741	CDD:425404	14/39 (36%)
		C2H2 Zn finger	742..764	CDD:275368	19/21 (90%)
		zf-H2C2_2	756..783	CDD:463886	22/26 (85%)
		C2H2 Zn finger	772..794	CDD:275368	17/21 (81%)
		zf-H2C2_2	786..809	CDD:463886	17/22 (77%)
		zf-C2H2	800..822	CDD:395048	17/21 (81%)
		C2H2 Zn finger	802..822	CDD:275368	16/19 (84%)