DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SP1 and pad

DIOPT Version :10

Sequence 1:NP_612482.2 Gene:SP1 / 6667 HGNCID:11205 Length:785 Species:Homo sapiens
Sequence 2:NP_650534.2 Gene:pad / 41981 FlyBaseID:FBgn0038418 Length:924 Species:Drosophila melanogaster


Alignment Length:926 Identity:210/926 - (22%)
Similarity:306/926 - (33%) Gaps:303/926 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    64 LAATCSRIESPNENSNNSQGPSQSGG----TGELDLTATQLSQGANGWQIISSSSGATPTSKEQS 124
            |.|||...::...|..|.: |:.|..    ...:|.|...||        ::.|:...|...:||
  Fly    76 LRATCRNSQTMLNNCLNIR-PAPSSDKLYIRDAVDETGKSLS--------VAQSAPPVPNGAQQS 131

Human   125 GSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQ--VLTGLPGV-MPNIQYQVIPQFQTVDGQQ 186
            |:..|.                  :..|.|:|.||  .:|...|| ....|:|.:|:.|....:|
  Fly   132 GNLLNS------------------IIQAVNMQPQQQYTITMDNGVQQQQQQHQAMPEVQIKSERQ 178

Human   187 ------------LQFAATG-------AQVQQDGSGQIQ-IIPGANQQIITNRGSGGNIIAAMPNL 231
                        ::....|       |:.||..|.|.| :.|..|...:..:...|:.:..:...
  Fly   179 TALEEFIRLKPDIKITPLGKKEPISPAKPQQQHSLQSQTVTPTINPTQLQLQPQLGDQLQPLWQQ 243

Human   232 LQQ---AVPLQGLANNVLSGQTQY-VTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQ 292
            :||   ...||.|.|. |...||| |.....:.:|:.....:|.|.::...|.     .::|..|
  Fly   244 IQQLQLQQQLQQLTNQ-LQATTQYSVAQDDTSSSGDSKKPKLNFVLSSPTAPQ-----FTTSMPQ 302

Human   293 ESGSQP------------VTSG------TTISSASLVSSQASSSSFFTN---------------- 323
            ..||||            |||.      |.:::|:|:||.|...| .||                
  Fly   303 FGGSQPQIQLQLMPGSGGVTSAGTVPAQTQLNAAALLSSLAGPQS-TTNLLSPNKCFLPITIRDE 366

Human   324 ------------ANSYSTTT------------TTSNMGIMNFTTSGSSGTNSQGQTPQRV----S 360
                        .|....||            |.....||..|.:....|..  .|||.:    |
  Fly   367 NSDQQIVAHIDTKNLVLPTTYQVQMKLQPQLATADGQPIMQLTPTSIPATLQ--LTPQTLGNPGS 429

Human   361 GLQGSDALNIQQNQTSGGSLQAGQQ--KEGEQNQQTQQQQILIQPQ--------LVQGGQALQAL 415
            ..||:   .:.|||     ..|.||  .:.....|...|||:..|.        :::....:...
  Fly   430 AFQGT---TVTQNQ-----FLAPQQPLTQLPNTAQVTSQQIIRSPHTSTTNSQLVIRNVTNIPPT 486

Human   416 QAAPLSGQ---TFTTQAISQETLQNLQLQAVPNSGPIIIRTPTVGPN--GQVSWQTLQLQNL--- 472
            ...|.|.:   ||.|.:..|:.:.:      |.|      ..||||:  |.....|.:.:.|   
  Fly   487 PTTPTSSKKAPTFKTPSPKQKPMPS------PKS------KTTVGPSSGGSNGTSTNEFKRLITQ 539

Human   473 ---QVQNPQAQTITL----APMQGVSLGQTS----SSNTTLTPI-ASAASIPAGTVTVNAAQL-- 523
               |.|..|.||..|    || ...|..|.:    |||||:|.: ...||:||...|.|.|:|  
  Fly   540 TKPQPQVKQQQTAGLSASGAP-TATSANQAAMQRLSSNTTITKVPKQPASLPAPAPTSNPAKLPM 603

Human   524 --------------------------SSMPGLQTINLSALGTSGIQVHPIQGLPLAIANAPGDHG 562
                                      |..|..|.|.:|....|..|..|:......|...|.:  
  Fly   604 LNKQNITISRISMQTAPKAQSKPSTTSPTPASQPIPVSVPALSQAQPPPLAAQHKKIVRKPPE-- 666

Human   563 AQLGLHGAGGDGIHDDTAG----------------GEEGENSPDAQPQAGRRTRREACTCPYCKD 611
                         :.||:|                .:||:|:..:..:|   .......||.||.
  Fly   667 -------------NQDTSGQKVKAARPPQQILPSPQQEGQNATHSGSEA---PTTSGLICPTCKR 715

Human   612 SEGRGSGDPGKKKQHI--------------CHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTWSY 662
            .        .|||:|:              |..:||.|.:.:..||..||..|:|::.:.|  ..
  Fly   716 E--------FKKKEHLTQHVKLHAGLRPFKCSEEGCDKTFSRKEHLSRHLVSHSGQKMYTC--EV 770

Human   663 CGKRFTRSDELQRHKRTHT---GEKKFACPECPKRFMRSDHLSKHIKTHQN---KKGGPGVALSV 721
            |.|.|:|.|.|.:|:|.||   .|..:.|..|.|.|....|..||.:.|:.   :...||...|.
  Fly   771 CKKPFSRKDNLNKHRRIHTQTSTETLYCCDVCNKNFATKLHYEKHREMHKKIRPESAAPGATASP 835

Human   722 GTLPLDSGAGSEG------------------SGTATPSA----LITTNMVAMEAI---------C 755
            ...|..:...|.|                  :.|..|.|    ::||..:|...|         .
  Fly   836 AAAPALTHVRSNGQVPNKAVFEIKQERSAQQTQTQQPPAQVMHVVTTQDLAGNTITITQAPDSNM 900

Human   756 PEGIARLANSGINVMQ 771
            |..:|.....|.:..|
  Fly   901 PGSLANYVQLGFSQFQ 916

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP1NP_612482.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..93 8/32 (25%)
Repressor domain 2..82 6/17 (35%)
SP1_N 54..627 CDD:411775 162/729 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..141 6/31 (19%)
Transactivation domain A (Gln-rich) 146..251 30/130 (23%)
Transactivation domain B (Gln-rich) 261..495 71/320 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 329..395 20/83 (24%)
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 462..470 1/7 (14%)
Transactivation domain C (highly charged) 496..610 33/162 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 567..598 7/46 (15%)
VZV IE62-binding 619..785 51/204 (25%)
zf-C2H2 626..650 CDD:395048 9/37 (24%)
C2H2 Zn finger 628..650 CDD:275368 8/21 (38%)
zf-H2C2_2 642..669 CDD:463886 10/26 (38%)
C2H2 Zn finger 658..680 CDD:275368 9/21 (43%)
zf-H2C2_2 672..695 CDD:463886 9/25 (36%)
zf-C2H2 686..708 CDD:395048 7/21 (33%)
C2H2 Zn finger 688..708 CDD:275368 7/19 (37%)
Domain D 708..785 18/98 (18%)
padNP_650534.2 zf-AD 16..88 CDD:462262 4/11 (36%)
PHA03247 <497..709 CDD:223021 54/242 (22%)
C2H2 Zn finger 710..730 CDD:275368 8/27 (30%)
zf-C2H2 736..760 CDD:395048 8/23 (35%)
C2H2 Zn finger 738..760 CDD:275368 8/21 (38%)
zf-C2H2 766..788 CDD:395048 9/23 (39%)
C2H2 Zn finger 768..788 CDD:275368 9/21 (43%)
zf-C2H2 797..819 CDD:395048 7/21 (33%)
C2H2 Zn finger 799..819 CDD:275368 7/19 (37%)

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