Protein Alignment SP1 and phol

DIOPT Version :10

• Sequence 1: NP_612482.2
• Gene: SP1 / 6667
• HGNCID: 11205
• Length: 785
• Species: Homo sapiens
• Sequence 2: NP_648317.1
• Gene: phol / 39095
• FlyBaseID: FBgn0035997
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 560
• Identity: 134/560 - (23%)
• Similarity: 207/560 - (36%)
• Gaps: 160/560 - (28%)

Human   253 VTNVPVALNGNITLLPVNSVSAAT------LTPSSQAVTISSSGSQESGSQPVTSGTT----ISS 307
            :|:|.||   ....||...:...|      :....|.:|.|..|..:...:.....||    |:|
  Fly   118 LTSVTVA---TADALPPPIIMQQTSDDEEFIEEDGQQMTSSCDGDGDEDDEATAPATTNAFEIAS 179

Human   308 ASLVSSQASS-------SSFFTNANSYSTTTTTSNMGIMNFTTSGSS------GTNS-----QGQ 354
            ..|.:.:|::       |.|:..|...|   .:||..:.:|...|||      |.::     |.:
  Fly   180 EMLTTIEATNIKEEQLESDFYMKATEDS---NSSNGQLQDFKLFGSSRVERPMGNSAAKRWKQTK 241

Human   355 TPQRVSGLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQQ---------------TQQQQILIQPQ 404
            .|.|::    .|..|:    |...||.:..:.|.|:.::               .|.:.....|:
  Fly   242 VPIRIT----QDEFNV----TLWSSLNSEDEDEEEELEEPPGCAGTTSVTSSSAAQNEGSPSMPK 298

Human   405 LV------------QG----------------------------GQALQALQAAPLSGQTFTTQA 429
            |:            .|                            |.......:.|||.|....:.
  Fly   299 LIIDEHMINHDVLSDGIGNEYVILPDPFSASAVTDVEEVVNAFMGDVKGEEDSQPLSEQLIYAEN 363

Human   430 ISQETLQNLQL-QAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLG 493
            ..:|...|::| :.:||:.. :|:||..|| ..|| ..|...|..|.|||       |.....:.
  Fly   364 QLEEAYGNIELIENMPNNVE-LIQTPGPGP-ATVS-VALSKVNGCVPNPQ-------PALPKLVL 418

Human   494 QTSSSNTTLTPIASAASIPAGTVTVNAAQLS--------------SMPGLQTINLSALGTSGIQV 544
            |.||:|..|....:.:.:....:|. |||::              :.|...||
  Fly   419 QNSSTNVRLKSAGNQSKVTKRQLTA-AAQVATPNPPPPLVASSNPARPQRPTI------------ 470

Human   545 HPIQGLPLAIANAPGDHGAQLGLHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTRREACTCPYC 609
              :..||.|:||....:..     ||.|       |.|||     |.:|:.  |.....|...:.
  Fly   471 --VTKLPTAVANQTAGNAM-----GAAG-------AAGEE-----DEEPKF--RCTHRGCNKEFR 514

Human   610 KDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTWSYCGKRFTRSDELQ 674
            ..|..|........:.|:|::  |||.:.::|.|:.|...||||:||.||:..|||||:....|:
  Fly   515 NHSAMRKHMHTHGPRGHVCNV--CGKSFVESSKLKRHQLVHTGEKPFECTFEGCGKRFSLDFNLR 577

Human   675 RHKRTHTGEKKFACP--ECPKRFMRSDHLSKHIKTHQNKK 712
            .|.|.|||::.:.||  .|.|.|.:|.:|..|:.||...|
  Fly   578 THVRIHTGDRPYHCPIDGCSKCFAQSTNLKSHMLTHTKPK 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1	NP_612482.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..93
		Repressor domain	2..82
		SP1_N	54..627	CDD:411775	96/471 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..141
		Transactivation domain A (Gln-rich)	146..251
		Transactivation domain B (Gln-rich)	261..495		62/317 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	329..395		17/91 (19%)
		9aaTAD. /evidence=ECO:0000269|PubMed:31375868	462..470		3/7 (43%)
		Transactivation domain C (highly charged)	496..610		27/127 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	567..598		9/30 (30%)
		VZV IE62-binding	619..785		38/96 (40%)
		zf-C2H2	626..650	CDD:395048	8/23 (35%)
		C2H2 Zn finger	628..650	CDD:275368	7/21 (33%)
		zf-H2C2_2	642..669	CDD:463886	15/26 (58%)
		C2H2 Zn finger	658..680	CDD:275368	10/21 (48%)
		zf-H2C2_2	672..695	CDD:463886	10/24 (42%)
		zf-C2H2	686..708	CDD:395048	8/23 (35%)
		C2H2 Zn finger	688..708	CDD:275368	8/21 (38%)
		Domain D	708..785		2/5 (40%)
phol	NP_648317.1	COG5048	<504..614	CDD:227381	39/111 (35%)
		C2H2 Zn finger	504..526	CDD:275368	3/21 (14%)
		C2H2 Zn finger	533..553	CDD:275368	7/21 (33%)
		C2H2 Zn finger	561..583	CDD:275368	10/21 (48%)
		C2H2 Zn finger	591..613	CDD:275368	8/21 (38%)