Protein Alignment SOX12 and Hmg-2

DIOPT Version :10

• Sequence 1: NP_008874.2
• Gene: SOX12 / 6666
• HGNCID: 11198
• Length: 315
• Species: Homo sapiens
• Sequence 2: NP_611553.1
• Gene: Hmg-2 / 37407
• FlyBaseID: FBgn0026582
• Length: 376
• Species: Drosophila melanogaster
• Alignment Length: 300
• Identity: 56/300 - (18%)
• Similarity: 98/300 - (32%)
• Gaps: 95/300 - (31%)

Human    37 SGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREA-------- 93
            :|..|.|:|.::.:....|.::..:.|.....|.::.:|..|..|.:..|:|::..|
  Fly    73 AGAPKMPLNGYVRFMNDRREELRREQPQRTALEHTRIIGEEWHQLPEERKLPYIEAAAKDKAIYQ 137

Human    94 ERLRLKHMADYPDY------KYRPRKKSKGAPAKARPRPPGGSGGGSRLKPGPQLPGRGGRRAAG 152
            |:|:: .:.::|:.      |.:...|..|:|.:..|:.....|...:.|..|
  Fly   138 EQLQM-FLKEHPEIVANELAKAKKATKLDGSPKEKTPKGESALGKAKKTKAKP------------ 189

Human   153 GPLGGGAAAPEDDDEDDDEELLEVRLVETPGRELWRMVPAGRAARGQAERAQGPSGEGAAAAAAA 217
                    .....::.||..|.:|:..:||      ..|...||..|..    ||....|..|..
  Fly   190 --------VKRQSEDPDDVPLAKVKRAQTP------PPPTPPAAPVQPP----PSSVPPATPAPR 236

Human   218 SPTPSE-----------DEEPEEE-----------EEEAAAAEEGEEETVAS-----GE------ 249
            ...|.|           :...|.|           |::.|..|:..:.|.|.     ||
  Fly   237 PLQPGEIPIYTNEFIEHNRSTENELRTLRKAKTDLEQQNAVLEQHVDNTKAGYAKVMGEVTELME 301

Human   250 -----------------ESLGFLSRLPPGPAGLDCSALDR 272
                             .:||.:|..|..|:|.....:|:
  Fly   302 ENQRLETYLRALRQKLVAALGGISMPPLEPSGPSVGNIDK 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOX12	NP_008874.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		1/2 (50%)
		HMG-box_SF	29..116	CDD:469606	18/92 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..288		41/228 (18%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000250|UniProtKB:Q04890	283..315
Hmg-2	NP_611553.1	HMG-box_HMG20	75..154	CDD:438796	15/79 (19%)