Protein Alignment SOX15 and cic

DIOPT Version :10

• Sequence 1: NP_008873.1
• Gene: SOX15 / 6665
• HGNCID: 11196
• Length: 233
• Species: Homo sapiens
• Sequence 2: NP_001262755.1
• Gene: cic / 53560
• FlyBaseID: FBgn0262582
• Length: 2150
• Species: Drosophila melanogaster
• Alignment Length: 221
• Identity: 64/221 - (28%)
• Similarity: 97/221 - (43%)
• Gaps: 61/221 - (27%)

Human    17 PAATAAASSSSG---------PQEREGAGSPAAPGTLPLEKVKRPMNAFMVWSSAQRRQMAQQNP 72
            ||.:||...|..         .|::.||...|| |....:|::|||||||::|...|:.:.:::|
  Fly  1192 PATSAAKRRSQSLSALQQQQQQQQQAGAAGTAA-GQPANKKIRRPMNAFMIFSKKHRKMVHKKHP 1255

Human    73 KMHNSEISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKY--RPRRKAKSSGAGPSRCG 135
            ...|..:||.||..|..|..::|..:.|.|..::..|.:.:|::|:  :.|||:.:|.|.|
  Fly  1256 NQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTATP---- 1316

Human   136 QGRGNLASGGPLWGPGYATTQ---------------PSRGFGYRPPSYSTAYLPGSYGSSHCKLE 185
               |..|||..  |.|.|..:               ||              .||  ||..|..:
  Fly  1317 ---GGKASGAA--GTGDAKQRLVSVDGSDSLEHDMCPS--------------TPG--GSGSCGGQ 1360

Human   186 APSPCSLPQSDPRLQGELLP-TYTHY 210
            ..|      ||  |||:::| |..:|
  Fly  1361 GIS------SD--LQGDIIPLTIDNY 1378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOX15	NP_008873.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48		11/39 (28%)
		Required to promote HAND1 transcriptional activator activity. /evidence=ECO:0000250|UniProtKB:P43267	1..47		11/38 (29%)
		HMG-box_SoxA_SoxB_SoxG	48..123	CDD:438837	25/76 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..153		14/41 (34%)
		Interaction with FHL3. /evidence=ECO:0000250|UniProtKB:P43267	138..183		13/59 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..233		1/3 (33%)
cic	NP_001262755.1	DUF4819	349..432	CDD:465014
		HMG-box_CIC-like	1231..1308	CDD:438806	25/76 (33%)