Protein Alignment SOX15 and Sox14

DIOPT Version :10

• Sequence 1: NP_008873.1
• Gene: SOX15 / 6665
• HGNCID: 11196
• Length: 233
• Species: Homo sapiens
• Sequence 2: NP_476894.1
• Gene: Sox14 / 37822
• FlyBaseID: FBgn0005612
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 195
• Identity: 61/195 - (31%)
• Similarity: 95/195 - (48%)
• Gaps: 69/195 - (35%)

Human     4 PGS--SQDQAWSLEP-----PAATAAASSSSGPQ-------------------------EREGAG 36
            ||:  :|.||....|     |:|..||::...|:                         |.:|..
  Fly    74 PGAQKTQSQAAITHPAAVASPSAPVAAAAPKTPKTPEPRSTHTHTHTHSQHFSPPPRESEMDGER 138

Human    37 SPAAPG---TLPLE---------------------------------KVKRPMNAFMVWSSAQRR 65
            ||:..|   ||.::                                 .:|||||||||||..:||
  Fly   139 SPSHSGHEMTLSMDGIDSSLVFGSARVPVNSSTPYSDATRTKKHSPGHIKRPMNAFMVWSQMERR 203

Human    66 QMAQQNPKMHNSEISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKYRPRRK-AKSSGA 129
            ::.::.|.:||:||||.||.:|:||.:|:|:|::.||::||..|:.:||:|||||::| .:|.|:
  Fly   204 KICERTPDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLRKLHMIEYPNYKYRPQKKQTRSPGS 268

Human   130  129
              Fly   269  268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOX15	NP_008873.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48		18/111 (16%)
		Required to promote HAND1 transcriptional activator activity. /evidence=ECO:0000250|UniProtKB:P43267	1..47		18/77 (23%)
		HMG-box_SoxA_SoxB_SoxG	48..123	CDD:438837	40/74 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..153		10/18 (56%)
		Interaction with FHL3. /evidence=ECO:0000250|UniProtKB:P43267	138..183
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..233
Sox14	NP_476894.1	HMG-box_SoxC	186..261	CDD:438838	40/74 (54%)