Protein Alignment SOX15 and Sox15

DIOPT Version :10

• Sequence 1: NP_008873.1
• Gene: SOX15 / 6665
• HGNCID: 11196
• Length: 233
• Species: Homo sapiens
• Sequence 2: NP_523739.2
• Gene: Sox15 / 36575
• FlyBaseID: FBgn0005613
• Length: 784
• Species: Drosophila melanogaster
• Alignment Length: 184
• Identity: 64/184 - (34%)
• Similarity: 97/184 - (52%)
• Gaps: 32/184 - (17%)

Human    48 KVKRPMNAFMVWSSAQRRQMAQQNPKMHNSEISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRD 112
            :::|||||||||:..:|:::|.:||.:||:::||.||.:|:.|...::||:||||:|||..|:.:
  Fly   214 RIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTE 278

Human   113 YPDYKYRPRR----KAKSSGAGPSRCGQGRGNLASGGPLWGPGYATTQPSRGFGYRPPSYSTAYL 173
            :|:|||||||    |.::...|.....:...|..:||....|..||           |..:||
  Fly   279 HPNYKYRPRRRKQSKLRAMQPGGKEQSESSPNPGTGGSKSNPKLAT-----------PPLATA-- 330

Human   174 PGSYGSSHCKLEAPSPCSLP-----QSDP--RLQGELLPTYTHYLPPGSPTPYN 220
                .||:......|.|:..     ||.|  ..:..|.|||:    |.|...|:
  Fly   331 ----SSSYTTPTDESTCNSTNQNHGQSTPGGLYEQPLKPTYS----PSSVDCYS 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOX15	NP_008873.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48		64/184 (35%)
		Required to promote HAND1 transcriptional activator activity. /evidence=ECO:0000250|UniProtKB:P43267	1..47
		HMG-box_SoxA_SoxB_SoxG	48..123	CDD:438837	39/78 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..153		14/43 (33%)
		Interaction with FHL3. /evidence=ECO:0000250|UniProtKB:P43267	138..183		11/44 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..233		3/13 (23%)
Sox15	NP_523739.2	HMG-box_SoxF	214..289	CDD:438841	38/74 (51%)
		PHA03273	305..>391	CDD:223031	23/93 (25%)