DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SOX11 and Sox100B

DIOPT Version :9

Sequence 1:	NP_003099.1	Gene:	SOX11 / 6664	HGNCID:	11191	Length:	441	Species:	Homo sapiens
Sequence 2:	NP_651839.1	Gene:	Sox100B / 45039	FlyBaseID:	FBgn0024288	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	455	Identity:	129/455 - (28%)
Similarity:	178/455 - (39%)	Gaps:	156/455 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    48 HIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMAD 112
            ||||||||||||::..||.:.:|.|.:.|:|:||.|||.||.||||:|.||:..||:||:.|..:
  Fly    76 HIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLGKLWKNLKDSDKKPFMEFAEKLRMTHKQE 140

Human   113 YPDYKYRPRKK-----------------PKMDPSAKPSASQSPEKSAAGG----GGGSAGGGAG- 155
            :|||||:||:|                 |:|..||...:|..|..|.:.|    |.|:|....|
  Fly   141 HPDYKYQPRRKKARVLPSQQSGEGGSPGPEMTLSATMGSSGKPRSSNSNGQRRAGKGNAAADLGS 205

Human   156 ----------GAKTS---------KGSSKKCGK-----------LKAP----------------- 173
                      |:.:|         |..:..|..           |.:|
  Fly   206 CASTISHANVGSNSSDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPCSTASSMSSLTPPATPY 270

Human   174 --AAAGAKAGAGK------------AAQSGD-YG---GAGDDYV-LGSLRV--------SGSGGG 211
              |.:.|||.|..            .|.:|| ||   .||.:|| :|.:..        ||:.||
  Fly   271 NVAPSNAKASAANNPSLLLRQLSEPVANAGDGYGVLLEAGREYVAIGEVNYQGQSAGVQSGAEGG 335

Human   212 GAGKTVKCVFLDE-DDDDDDDDDELQLQIKQEPDE----EDEEPPHQQLLQPPGQQPSQLLRRYN 271
            |||:.:.  ||:. :.........:.......|..    ..||...||.|     |.|:.| .|.
  Fly   336 GAGQEMD--FLENINGYGGYTGSRVSYPAYSYPANGGHFATEEQQQQQAL-----QASEAL-NYK 392

Human   272 VAKVPASPTLSSSAESPEGASLY--DEVRAGATSGAGGGSRLYYSFKNITKQHPP----PLAQPA 330
                ||:..:     .|:....|  |::..                  :|:.|.|    ||..|.
  Fly   393 ----PAAADI-----DPKEIDQYFMDQMLP------------------MTQHHHPHHTHPLHHPL 430

Human   331 -LSPASSRSVSTSSSSSSGSSSGSSGEDADDLMFDLSLNFSQSAHSAS-------EQQLGGGAAA 387
             .||..:.|.|.||:.||.||.....|      :...|.:|.:|.|||       :|....|||:
  Fly   431 HHSPPLNSSASLSSACSSASSQQPVAE------YYEHLGYSPAASSASQNPNFGPQQPYANGAAS 489

Human 388 387
Fly 490 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SOX11	NP_003099.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SOX-TCF_HMG-box	48..119	CDD:238684	41/70 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..216		46/195 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..292		13/55 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..359		17/44 (39%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000250\|UniProtKB:Q7M6Y2	409..441
Sox100B	NP_651839.1	SOX-TCF_HMG-box	76..146	CDD:238684	40/69 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810