DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SOX11 and Sox15

DIOPT Version :9

Sequence 1:	NP_003099.1	Gene:	SOX11 / 6664	HGNCID:	11191	Length:	441	Species:	Homo sapiens
Sequence 2:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	427	Identity:	108/427 - (25%)
Similarity:	181/427 - (42%)	Gaps:	108/427 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    49 IKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADY 113
            |:|||||||||:||||:|:.:::||:|||::||.|||:|:.|...::.|::.||||||:.||.::
  Fly   215 IRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEH 279

Human   114 PDYKYRPRKKPK-----MDPSAKPSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKKCGKLKAP 173
            |:||||||::.:     |.|..|..:..||..            |.||:|::.       ||..|
  Fly   280 PNYKYRPRRRKQSKLRAMQPGGKEQSESSPNP------------GTGGSKSNP-------KLATP 325

Human   174 AAAGAKAGAGKAAQSGDYGGAGDDYVLGSLRVS---GSGGGGAGKTVKCVFLDEDDD---DDDDD 232
            ..|.|         |..|....|:....|...:   .:.||...:.:|..:.....|   :.|..
  Fly   326 PLATA---------SSSYTTPTDESTCNSTNQNHGQSTPGGLYEQPLKPTYSPSSVDCYSNADST 381

Human   233 DELQ-LQIKQEPDEEDEEPPHQQLLQPPGQQPSQLLRRYNVAKVPASPT---------LSSSAES 287
            :::: |.....|...:|..|     ...|...|.||::.    ...||:         |:.|.|.
  Fly   382 EQIESLAANCPPALLNESSP-----TGGGYDNSLLLKKL----TKPSPSRAAKSRQEKLAKSEEK 437

Human   288 PEGASLYDEVRAG---------ATSGAGGGSR-LYYSFKN---ITKQH--------PPPLAQPAL 331
            .:|:....:.:.|         .||.|...:| :|.:..|   :...|        |..:::...
  Fly   438 NKGSQSQGQSQQGIYAATYPLAPTSVAVVAARGMYVTCNNRGLLDHGHSVKGTFYPPVSVSEDDN 502

Human   332 SPASSRSVS---------TSSSSSSGSSSGSSGEDADDLMFDLSLNFSQSAHSASEQQLGGGAAA 387
            |.:...|:|         ||:.||||.:..:|               ..|:::.|...     ..
  Fly   503 STSMRNSISALQQHCNVVTSTPSSSGGTMPTS---------------EMSSYTVSMAD-----NC 547

Human   388 GNLSLSLVDKDLDSFSEGSLGSHFEFPDYCTPELSEM 424
            |||.||:.:...:.:...:.....::.|:...:.::|
  Fly   548 GNLRLSMNELSGNEYLPSANAYGMQYEDFLRYQSNDM 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SOX11	NP_003099.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SOX-TCF_HMG-box	48..119	CDD:238684	39/69 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..216		26/107 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..292		13/60 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..359		12/56 (21%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000250\|UniProtKB:Q7M6Y2	409..441		2/16 (13%)
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	39/69 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910