DRSC/TRiP Functional Genomics Resources

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Protein Alignment SOX10 and Sox100B

DIOPT Version :9

Sequence 1:NP_008872.1 Gene:SOX10 / 6663 HGNCID:11190 Length:466 Species:Homo sapiens
Sequence 2:NP_651839.1 Gene:Sox100B / 45039 FlyBaseID:FBgn0024288 Length:529 Species:Drosophila melanogaster


Alignment Length:487 Identity:146/487 - (29%)
Similarity:194/487 - (39%) Gaps:114/487 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    55 KKEQQDGEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAAR 119
            |.:.|.|..:|::    |..||.:||.||||.||....:. ...:.|.|:|||||||||||||||
  Fly    33 KAQGQGGRKEDER----ITTAVMKVLEGYDWNLVQASAKA-PTDRKKEHIKRPMNAFMVWAQAAR 92

Human   120 RKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKN---G 181
            |.::.|||||.|:||||:|||||:.|.:|||:||:|.||:|||.||::||||||||||:|.   .
  Fly    93 RVMSKQYPHLQNSELSKSLGKLWKNLKDSDKKPFMEFAEKLRMTHKQEHPDYKYQPRRKKARVLP 157

Human   182 KAAQGEAECPGGEAEQGGTAAIQAHYKSAHLD-HRHPGEGSPMSD-----GNPEH---------- 230
            ....||...||.|.....|.......:|::.: .|..|:|:..:|     ....|          
  Fly   158 SQQSGEGGSPGPEMTLSATMGSSGKPRSSNSNGQRRAGKGNAAADLGSCASTISHANVGSNSSDV 222

Human   231 --------------------------------PSGQSHGPPTPPTTPKTELQS-GKADPKRD--- 259
                                            .:..|....|||.||.....| .||....:   
  Fly   223 FSNEAFMKSLNSACAASLMEQSLIETGLDSPCSTASSMSSLTPPATPYNVAPSNAKASAANNPSL 287

Human   260 ------------GRSMG---EGGKPHIDFGNVDIGEISHEVMSNMETFDVA-ELDQYLPPNGHPG 308
                        |...|   |.|:.::..|.|:....|..|.|..|..... |:|.....||:.|
  Fly   288 LLRQLSEPVANAGDGYGVLLEAGREYVAIGEVNYQGQSAGVQSGAEGGGAGQEMDFLENINGYGG 352

Human   309 HVS---SYSAAGYGLGSALAVASGHSAWISKPPGVALPTVSPPGVDAKAQVKTETAGPQGPPHYT 370
            :..   ||.|..|      ....||.|...:....||        .|...:..:.|.....|...
  Fly   353 YTGSRVSYPAYSY------PANGGHFATEEQQQQQAL--------QASEALNYKPAAADIDPKEI 403

Human   371 DQPSTSQ-IAYTSLSLPHYG-------------SAFPSISRPQFDYSDHQPSGPYYGHSGQASGL 421
            ||....| :..|....||:.             ::..|:|......|..||...||.|.|.:...
  Fly   404 DQYFMDQMLPMTQHHHPHHTHPLHHPLHHSPPLNSSASLSSACSSASSQQPVAEYYEHLGYSPAA 468

Human   422 YSAFSYMGPSQRPLYTAISDPSPSGPQSHSPT 453
            .||      ||.|.: ....|..:|..|.:||
  Fly   469 SSA------SQNPNF-GPQQPYANGAASMTPT 493

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SOX10NP_008872.1 Sox_N 12..93 CDD:315171 15/37 (41%)
Dimerization (DIM). /evidence=ECO:0000303|PubMed:31194875 62..102 12/39 (31%)
SOX-TCF_HMG-box 103..173 CDD:238684 50/69 (72%)
Nuclear export signal 134..145 8/10 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..199 21/41 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..274 18/128 (14%)
Transactivation domain (TAM). /evidence=ECO:0000303|PubMed:31194875 228..310 25/143 (17%)
Transactivation domain (TAC). /evidence=ECO:0000303|PubMed:31194875 353..466 27/115 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..375 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 433..466 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..67 4/11 (36%)
Sox100BNP_651839.1 SOX-TCF_HMG-box 76..146 CDD:238684 50/69 (72%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 115 1.000 Domainoid score I6018
eggNOG 1 0.900 - - E1_KOG0527
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 181 1.000 Inparanoid score I3995
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000028
OrthoInspector 1 1.000 - - otm40903
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45803
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5318
SonicParanoid 1 1.000 - - X1210
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.990

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