DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SOX9 and Sox15

DIOPT Version :9

Sequence 1:	NP_000337.1	Gene:	SOX9 / 6662	HGNCID:	11204	Length:	509	Species:	Homo sapiens
Sequence 2:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	144/542 - (26%)
Similarity:	202/542 - (37%)	Gaps:	145/542 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    19 SGAPSPTMSEDSAGSPCPSGS------------GSDTEN---TRPQENTFPKGEPDLKKESEEDK 68
            |.:|.|.:|....|....|||            |:...|   :.|.......|...:  |.....
  Fly   101 SHSPMPMVSSAYVGGGTASGSLINSNIPLLGGGGNSVLNKFLSHPHAGMVGGGTGQM--EDCTSH 163

Human    69 FPVCIREAVSQVLKGYDWTLV-----------PMPV----RVNGS---SKNKPHVKRPMNAFMVW 115
            .|:   ||.|.....|...|.           |:|.    |..|:   |..:..::|||||||||
  Fly   164 SPI---EAASMWSYDYKGDLCAPNCGYLERHKPLPADLKYRPGGTQSKSAKESRIRRPMNAFMVW 225

Human   116 AQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRK 180
            |:..|:||||:.|.||||:|||.|||.||.|...::||:|||||||||.|..:||:|||:|||||
  Fly   226 AKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRK 290

Human   181 SVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPP---TPP---- 238
            ..|. :|......||:..|||                      ||  :|.|:..|   |||
  Fly   291 QSKL-RAMQPGGKEQSESSPN----------------------PG--TGGSKSNPKLATPPLATA 330

Human   239 ----TTPKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLP 299
                ||| ||.....:..:..|:..|.|..:.|:   .......|.|..||.   |..|..:.|.
  Fly   331 SSSYTTP-TDESTCNSTNQNHGQSTPGGLYEQPL---KPTYSPSSVDCYSNA---DSTEQIESLA 388

Human   300 PNGHPGVPATHGQVTYTGSYGISSTAATPASAGHVWMSKQQAPPPPPQQPPQAPPAPQAPPQPQA 364
            .|..|.:              ::.::.|.....:..:.|:...|.|.:               .|
  Fly   389 ANCPPAL--------------LNESSPTGGGYDNSLLLKKLTKPSPSR---------------AA 424

Human   365 APPQQPAAPPQQPQAHTLTTLSSEPGQSQR-THIKTEQLSPSHYSEQQQHSPQQIAYSPFNLPH- 427
            ...|:..|..::....     |...||||: .:..|..|:|:..:............:...|.|
  Fly   425 KSRQEKLAKSEEKNKG-----SQSQGQSQQGIYAATYPLAPTSVAVVAARGMYVTCNNRGLLDHG 484

Human   428 ---YSPSYPPITRSQYD-YTDHQNS------------SSYYSHAAGQGTGLYSTFTY-------- 468
               ....|||::.|:.| .|..:||            |:..|......|...|::|.
  Fly   485 HSVKGTFYPPVSVSEDDNSTSMRNSISALQQHCNVVTSTPSSSGGTMPTSEMSSYTVSMADNCGN 549

Human   469 ----MNPAQRPMYTPIADTSGV 486
                ||......|.|.|:..|:
  Fly   550 LRLSMNELSGNEYLPSANAYGM 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SOX9	NP_000337.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		13/62 (21%)
		Sox_N	22..94	CDD:403592	20/101 (20%)
		Dimerization (DIM). /evidence=ECO:0000305\|PubMed:31194875	63..103		12/57 (21%)
		PQA. /evidence=ECO:0000305\|PubMed:31194875	63..103		12/57 (21%)
		SOX-TCF_HMG-box	104..174	CDD:238684	44/69 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..273		39/123 (32%)
		Transactivation domain (TAM). /evidence=ECO:0000269\|PubMed:31194875	224..307		26/93 (28%)
		9aaTAD 1. /evidence=ECO:0000269\|PubMed:31194875	275..284		2/8 (25%)
		9aaTAD 2. /evidence=ECO:0000269\|PubMed:31194875	290..298		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..415		14/85 (16%)
		Transactivation domain (TAC). /evidence=ECO:0000269\|PubMed:8640233	394..509		24/123 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..509		3/8 (38%)
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	45/70 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810