DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fastk and CG31643

DIOPT Version :9

Sequence 1:	NP_075718.2	Gene:	Fastk / 66587	MGIID:	1913837	Length:	545	Species:	Mus musculus
Sequence 2:	NP_001285652.1	Gene:	CG31643 / 318867	FlyBaseID:	FBgn0051643	Length:	899	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	123/552 - (22%)
Similarity:	206/552 - (37%)	Gaps:	124/552 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    26 ESWSPPPSS--MLRILLSAQTSPARL-----SGLLLIPPVQPCCLGPSKSGDRPFGGGPVQGLQR 83
            |:|..|.:|  :..:|.:.:.|....     ||  ::..::.|   |.|.....|    ::..||
  Fly   378 EAWQQPNASGHLFSVLRALKVSDIEFCNTYWSG--VVKELESC---PEKHLHLRF----LRHCQR 433

Mouse    84 LLEQARSPG------ELLRWLSQNPTKVRAH----HYPVALRRLGQLLVSQPR--------PSPV 130
            .:....:.|      ||.|.||:.......|    ..|....||...:::..:        |:.:
  Fly   434 YMNFNNNLGGTYRHLELERKLSRMCMNAIEHDIAGRLPAKFARLASFVLAYGQTPLAWKKFPNFL 498

Mouse   131 EQATLQDLSQLIIRNCPSFD-----VHTIHVCLHLAVLLGF---PSDGPLL-CALEQERRSRLPP 186
            ....|....||.|::|....     ...:....||..|.|.   ..|..|: ||   ||..|...
  Fly   499 LSKMLAMAPQLGIQDCFLLSRGMQIASELRFRQHLPALAGMQLSTMDSILIGCA---ERHLRDAE 560

Mouse   187 KPP------------SPHRPAIYGGQRLEVALSCPRFLQYPRQHLIRSLAEARPEELTPHVMVLL 239
            |.|            ..||..:........||:     ||...|.         .:|...|:..:
  Fly   561 KDPLNASELSMIVRTLSHRKKLKNTVVYNQALA-----QYKNLHC---------NDLNSRVVRDM 611

Mouse   240 AQHLARHRLREPQLLEAIAHFLVVQEAQLNSKVVQKLVLPFGRLNYMPLEQQFMPCLERILAREA 304
            |.:........|:|||::..::..|...::...|:|::.....|.|||...:.:.....:|.|:.
  Fly   612 AYNFNASNFFVPELLESMFAYISEQHDHVSGDTVEKVLTCSYNLGYMPASVEALNHASEVLLRDF 676

Mouse   305 G-VAPLATVNILMSLCQLQCLPFRALQFVFSPSFINHI---------NGTPPSLIVRRYLSLLDT 359
            . ::.|:.|...::||..:.:|.:.:..||...||..|         ..|.|..::...:. |:.
  Fly   677 DQMSGLSVVQACLALCFYKSIPEQLINQVFCVKFIQRIEDEIQVCYSKATYPERVLNLVMQ-LNR 740

Mouse   360 AVELELPGYQGPRLPQRQRVPIFPQPLITDRARCKYSHKDM--------VAEGLRQLL-GEENYR 415
            .|.|:.|         ...||.|.|..|    ..:.|.|.:        |.:.|.||| .::::|
  Fly   741 TVCLDFP---------EANVPWFQQNYI----EAQISKKSLIPSESTTEVKQLLHQLLQNDKHFR 792

Mouse   416 QNLTVPPGYCTDFLLCVSSSGAVLPMRTQDPFLPYPPRSCQQDQANFNSTTQDPAQRVVLMLRER 480
            .|.|.|.||..||::...        |.::| :|.||         ..:|..|...:|.::|.:.
  Fly   793 CNHTTPYGYQIDFVIHFD--------RDKNP-IPAPP---------VEATMLDRITKVAILLLKL 839

Mouse   481 WHFC-RDGRVLLGSRALRERHLGLMGYQLLPL 511
            ..|| .|...|.|..:|:.|||.:|||:::.:
  Fly   840 DSFCENDLTALRGPESLKMRHLEMMGYKVMQI 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fastk	NP_075718.2	FAST_1	274..339	CDD:284217	15/65 (23%)
		FAST_2	354..439	CDD:285557	24/93 (26%)
		RAP	480..532	CDD:214932	12/33 (36%)
CG31643	NP_001285652.1	FAST_1	647..713	CDD:284217	16/65 (25%)
		FAST_2	736..816	CDD:285557	26/102 (25%)
		RAP	834..894	CDD:214932	13/38 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8291
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21228
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7659
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.990