DRSC/TRiP Functional Genomics Resources

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Protein Alignment SOX3 and ROX1

DIOPT Version :10

Sequence 1:NP_005625.2 Gene:SOX3 / 6658 HGNCID:11199 Length:446 Species:Homo sapiens
Sequence 2:NP_015390.1 Gene:ROX1 / 856178 SGDID:S000006269 Length:368 Species:Saccharomyces cerevisiae


Alignment Length:329 Identity:79/329 - (24%)
Similarity:118/329 - (35%) Gaps:106/329 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   138 RVKRPMNAFMVWSRGQRR-------KMALENPKMHNSEISKRLGADWKLLTDAEKRPFIDEAKRL 195
            ::.||.|||:::.:...|       ...:|.|  |||.|||.:|..||.|...:|..:.:.|::.
Yeast     9 KIPRPKNAFILFRQHYHRILIDEWTAQGVEIP--HNSNISKIIGTKWKGLQPEDKAHWENLAEKE 71

Human   196 RAVHMKEYPDYKYRPRRKTK---TLLK--------------KDKYSLPSGLLPPGAAAAAAAAAA 243
            :..|.::||:|||:|.||:|   .|||              :.|.|.|. |..|..........|
Yeast    72 KLEHERKYPEYKYKPVRKSKKKQLLLKEIEQQQQQQQKEQQQQKQSQPQ-LQQPFNNNIVLMKRA 135

Human   244 AAAAASSPVGVGQRLDTYTHVNGWANGAYSLVQEQL---------------GYAQPPSMSSPPPP 293
            .:.:.||.|.              ::.:|   |.||               .|....|:|     
Yeast   136 HSLSPSSSVS--------------SSNSY---QFQLNNDLKRLPIPSVNTSNYMVSRSLS----- 178

Human   294 PALPPMH---RYDMAGLQ--------YS-PMMPPGAQSYMNVAAAAAAASGYGGMAPSATAAAAA 346
             .||..|   ..|:..|.        || |..|.....|:|||.|          .|.|.:....
Yeast   179 -GLPLTHDKTARDLPQLSSQLNSIPYYSAPHDPSTRHHYLNVAQA----------QPRANSTPQL 232

Human   347 AY--------GQQPATAAAAAAAAAAMSLGPMGSVVKSEPSSPPPAIASHSQRACLGDLRDMISM 403
            .:        .|.|.|....:...|..|.|...       |||..::..:::   |..:.:. :.
Yeast   233 PFISSIINNSSQTPVTTTTTSTTTATSSPGKFS-------SSPNSSVLENNR---LNSINNS-NQ 286

Human   404 YLPP 407
            ||||
Yeast   287 YLPP 290

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SOX3NP_005625.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 29..48
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 87..140 0/1 (0%)
HMG-box_SoxB 137..212 CDD:438790 27/80 (34%)
SOXp 208..302 CDD:463537 27/128 (21%)
9aaTAD. /evidence=ECO:0000269|PubMed:34342803 399..407 2/7 (29%)
ROX1NP_015390.1 HMG-box_ROX1-like 10..86 CDD:438791 26/77 (34%)
Blue background indicates that the domain is not in the aligned region.

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