DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SOX3 and Sox100B

DIOPT Version :9

Sequence 1:	NP_005625.2	Gene:	SOX3 / 6658	HGNCID:	11199	Length:	446	Species:	Homo sapiens
Sequence 2:	NP_651839.1	Gene:	Sox100B / 45039	FlyBaseID:	FBgn0024288	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	323	Identity:	97/323 - (30%)
Similarity:	136/323 - (42%)	Gaps:	89/323 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   134 TD--QDRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGADWKLLTDAEKRPFIDEAKRLR 196
            ||  ::.:||||||||||::..||.|:.:.|.:.|||:||.||..||.|.|::|:||::.|::||
  Fly    70 TDRKKEHIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLGKLWKNLKDSDKKPFMEFAEKLR 134

Human   197 AVHMKEYPDYKYRPRRKTKTLLKKDKYSLPSGLLPPGAAAAAAAAAAAAAAASSPVGVGQR---- 257
            ..|.:|:|||||:||||...:|...: |...|  .||.....:|...::....|....|||
  Fly   135 MTHKQEHPDYKYQPRRKKARVLPSQQ-SGEGG--SPGPEMTLSATMGSSGKPRSSNSNGQRRAGK 196

Human   258 ----------LDTYTHVNGWANG-----------------AYSLVQEQL---GYAQP----PSMS 288
                      ..|.:|.|..:|.                 |.||:::.|   |...|    .|||
  Fly   197 GNAAADLGSCASTISHANVGSNSSDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPCSTASSMS 261

Human   289 SPPPPPALPPMHRYDMAGLQYSPMMPPGAQSYMNVAAA--------------AAAASGYGGMAPS 339
            | ..|||.|    |::|        |..|::    :||              |.|..|||.:..:
  Fly   262 S-LTPPATP----YNVA--------PSNAKA----SAANNPSLLLRQLSEPVANAGDGYGVLLEA 309

Human   340 ATAAAAAA----YGQQPATAAAAAAAAAAMSL----------GPMGSVVKSEPSSPPPAIASH 388
            .....|..    .||.....:.|....|...:          |..||.| |.|:...||...|
  Fly   310 GREYVAIGEVNYQGQSAGVQSGAEGGGAGQEMDFLENINGYGGYTGSRV-SYPAYSYPANGGH 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SOX3	NP_005625.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..48
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..140		2/7 (29%)
		SOX-TCF_HMG-box	138..209	CDD:238684	37/70 (53%)
		SOXp	208..302	CDD:289133	33/131 (25%)
Sox100B	NP_651839.1	SOX-TCF_HMG-box	76..146	CDD:238684	36/69 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810