DRSC/TRiP Functional Genomics Resources

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Protein Alignment SOX3 and Sox21a

DIOPT Version :10

Sequence 1:NP_005625.2 Gene:SOX3 / 6658 HGNCID:11199 Length:446 Species:Homo sapiens
Sequence 2:NP_001261827.1 Gene:Sox21a / 39567 FlyBaseID:FBgn0036411 Length:407 Species:Drosophila melanogaster


Alignment Length:391 Identity:134/391 - (34%)
Similarity:161/391 - (41%) Gaps:142/391 - (36%)


- Green bases have known domain annotations that are detailed below.


Human    61 PSPPATLAHLLPAPAMYSLLETELKNPVGTPTQAAGTGGPAAP------GGAGKSSANA-AGGAN 118
            |.|||.||                 .|...||       |.||      ...|.|..|| ...:|
  Fly    68 PMPPADLA-----------------VPPAAPT-------PVAPKMHQHTHHHGNSHHNAPTSHSN 108

Human   119 SGGGSSGGASGGGGGTDQDRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGADWKLLTDA 183
            |..||...:        .|.:|||||||||||||||||||.:|||||||||||||||:|||||:.
  Fly   109 SNTGSHHNS--------HDHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEG 165

Human   184 EKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKDKYSLPSGLLPPGAAAAAAAAAAAAAAA 248
            :|||||||||||||:||||:||||||||||.|||   :|..:|.|....|...|.....|..|..
  Fly   166 QKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTL---NKSPVPGGGGGGGGGGANGGVNAGGAGN 227

Human   249 SSPVG---VGQRLD----------TYTHVNGWANG-------------------AYSLVQEQLGY 281
            |.|.|   ||...|          :..|::|..:.                   |.:.:..:.|:
  Fly   228 SGPSGPGSVGSPKDMQPQLSPLGQSLPHLHGHPHQSPYQSHPHHPHPHPHHVQLAAATLSAKYGF 292

Human   282 AQPPSMSSPPPPPALPPMHRYDM----------------AGLQY---------SPMMPPGAQSYM 321
            ..|..:|.|..|.|.|.:..|.:                ||..|         ||..||.     
  Fly   293 GSPLELSLPRLPNAFPGLAHYPLDPTLALDLQARLQAMYAGSIYHPWRYLPLISPETPPS----- 352

Human   322 NVAAAAAAASGYGGMAPSATAAAAAAYGQQPATAAAAAAAAAAMSLGPMGSVVKSEPSSPPPAIA 386
                           .||::....::||                       .||||.|||...:|
  Fly   353 ---------------PPSSSGTGISSYG-----------------------CVKSEKSSPNAVVA 379

Human   387 S 387
            |
  Fly   380 S 380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SOX3NP_005625.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 29..48
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 87..140 15/59 (25%)
HMG-box_SoxB 137..212 CDD:438790 64/74 (86%)
SOXp 208..302 CDD:463537 32/125 (26%)
9aaTAD. /evidence=ECO:0000269|PubMed:34342803 399..407
Sox21aNP_001261827.1 HMG-box_SoxB 119..198 CDD:438790 67/78 (86%)
Blue background indicates that the domain is not in the aligned region.

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