Protein Alignment SOX3 and Sox14

DIOPT Version :10

• Sequence 1: NP_005625.2
• Gene: SOX3 / 6658
• HGNCID: 11199
• Length: 446
• Species: Homo sapiens
• Sequence 2: NP_476894.1
• Gene: Sox14 / 37822
• FlyBaseID: FBgn0005612
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 228
• Identity: 81/228 - (35%)
• Similarity: 115/228 - (50%)
• Gaps: 35/228 - (15%)

Human    15 RVPADLARSILISL-PFPPDSLAHRPPSSAP--------TESQGLFT----VAAP----APGAPS 62
            |.||..|.|...:| ||.|.......||.||        |:||...|    ||:|    |..||.
  Fly    40 RHPAPKADSTPHTLPPFSPSPSPASSPSPAPAQTPGAQKTQSQAAITHPAAVASPSAPVAAAAPK 104

Human    63 PPATLAHLLPAP-AMYSLLETELKNPVGTPTQAAGTGGPAAPGGAGKSSANAAGGANSG---GGS 123
            .|.|     |.| :.::...|..:: ...|.:.:...|..:|..:|.....:..|.:|.   |.:
  Fly   105 TPKT-----PEPRSTHTHTHTHSQH-FSPPPRESEMDGERSPSHSGHEMTLSMDGIDSSLVFGSA 163

Human   124 SGGASGGGGGTDQDR--------VKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGADWKLL 180
            ....:.....:|..|        :|||||||||||:.:|||:....|.:||:||||.||..|:||
  Fly   164 RVPVNSSTPYSDATRTKKHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLL 228

Human   181 TDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRK 213
            :..:|:|:|.||::||.:||.|||:|||||::|
  Fly   229 SKDDKQPYIIEAEKLRKLHMIEYPNYKYRPQKK 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOX3	NP_005625.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..48		8/26 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..140		9/63 (14%)
		HMG-box_SoxB	137..212	CDD:438790	44/82 (54%)
		SOXp	208..302	CDD:463537	4/6 (67%)
		9aaTAD. /evidence=ECO:0000269|PubMed:34342803	399..407
Sox14	NP_476894.1	HMG-box_SoxC	186..261	CDD:438838	43/74 (58%)