Protein Alignment SOX3 and Sox15

DIOPT Version :10

• Sequence 1: NP_005625.2
• Gene: SOX3 / 6658
• HGNCID: 11199
• Length: 446
• Species: Homo sapiens
• Sequence 2: NP_523739.2
• Gene: Sox15 / 36575
• FlyBaseID: FBgn0005613
• Length: 784
• Species: Drosophila melanogaster
• Alignment Length: 469
• Identity: 115/469 - (24%)
• Similarity: 175/469 - (37%)
• Gaps: 170/469 - (36%)

Human    94 AAGTGGPAAPGGAGKSSANAAGGANSGGGSS----------GGASGGG----------------- 131
            :|..||..|.|....|:....|    |||:|          .|..|||
  Fly   110 SAYVGGGTASGSLINSNIPLLG----GGGNSVLNKFLSHPHAGMVGGGTGQMEDCTSHSPIEAAS 170

Human   132 --------------------------------GGTD-----QDRVKRPMNAFMVWSRGQRRKMAL 159
                                            |||.     :.|::|||||||||::.:|:|:|.
  Fly   171 MWSYDYKGDLCAPNCGYLERHKPLPADLKYRPGGTQSKSAKESRIRRPMNAFMVWAKIERKKLAD 235

Human   160 ENPKMHNSEISKRLGADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLL------ 218
            |||.:||:::||.||..|:.||..::||:::||:|||.:||.|:|:|||||||:.::.|
  Fly   236 ENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRKQSKLRAMQPG 300

Human   219 -KKDKYSLPSGLLPPGAAAAAA----AAAAAAAAASS---------------------PVGVGQR 257
             |:...|.|:    ||...:.:    |....|.|:||                     |.|:.::
  Fly   301 GKEQSESSPN----PGTGGSKSNPKLATPPLATASSSYTTPTDESTCNSTNQNHGQSTPGGLYEQ 361

Human   258 --LDTY--THVNGWANGAYSLVQEQLGYAQPPSMSSPPPPPALPPMHRYDMAGLQYSPMMPPGAQ 318
              ..||  :.|:.::|...:...|.|....||::.:...|..    ..||.:.|......|..::
  Fly   362 PLKPTYSPSSVDCYSNADSTEQIESLAANCPPALLNESSPTG----GGYDNSLLLKKLTKPSPSR 422

Human   319 SYMN----VAAAAAAASGYGGMAPSATAAAAAAYGQQPATAAAAAAAAAAMSLGPMG-------- 371
            :..:    :|.:.....|......|.....||.|...|.:.|..||....::....|
  Fly   423 AAKSRQEKLAKSEEKNKGSQSQGQSQQGIYAATYPLAPTSVAVVAARGMYVTCNNRGLLDHGHSV 487

Human   372 ------------------------------SVVKSEPSS-----PPPAIASH--SQRACLGDLRD 399
                                          :||.|.|||     |...::|:  |.....|:||
  Fly   488 KGTFYPPVSVSEDDNSTSMRNSISALQQHCNVVTSTPSSSGGTMPTSEMSSYTVSMADNCGNLR- 551

Human   400 MISM-------YLP 406
             :||       |||
  Fly   552 -LSMNELSGNEYLP 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOX3	NP_005625.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..48
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..140		19/109 (17%)
		HMG-box_SoxB	137..212	CDD:438790	41/74 (55%)
		SOXp	208..302	CDD:463537	27/129 (21%)
		9aaTAD. /evidence=ECO:0000269|PubMed:34342803	399..407		5/15 (33%)
Sox15	NP_523739.2	HMG-box_SoxF	214..289	CDD:438841	42/74 (57%)
		PHA03273	305..>391	CDD:223031	17/89 (19%)