DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SOX3 and sox3

DIOPT Version :10

Sequence 1:NP_005625.2 Gene:SOX3 / 6658 HGNCID:11199 Length:446 Species:Homo sapiens
Sequence 2:NP_001001811.2 Gene:sox3 / 30529 ZFINID:ZDB-GENE-980526-333 Length:300 Species:Danio rerio


Alignment Length:371 Identity:230/371 - (61%)
Similarity:256/371 - (69%) Gaps:71/371 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    76 MYSLLETELKNPVGTPTQAAGTGGPAAPGGAGKSSANAAGGANSGGGSSGGASGGGGGTDQDRVK 140
            ||:::|||:|:|:......:.|||.       .:|||                      ||||||
Zfish     1 MYNMMETEIKSPIPQSNTGSVTGGK-------NNSAN----------------------DQDRVK 36

Human   141 RPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGADWKLLTDAEKRPFIDEAKRLRAVHMKEYPD 205
            ||||||||||||||||||.||||||||||||||||||||||||||||||||||||||:||||:||
Zfish    37 RPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGADWKLLTDAEKRPFIDEAKRLRAMHMKEHPD 101

Human   206 YKYRPRRKTKTLLKKDKYSLPSGLLPPGAAAAAAAAAAAAAAASSPVGVGQRLDTYTHVNGWANG 270
            |||||||||||||||||||||.|||.||           |.|.::.|.||||:| |||:|||.|.
Zfish   102 YKYRPRRKTKTLLKKDKYSLPGGLLAPG-----------ANAVNNAVSVGQRMD-YTHMNGWTNS 154

Human   271 AYSLVQEQLGYAQPPSMSSPPPPPALPPMHRYDMAGLQYSPMMPPGAQSYMNVAAAAAAASGYGG 335
            ||||:|:||.|.|.|||:|    |.:..||||||||||| |||.. ||:|||      |||.|..
Zfish   155 AYSLMQDQLAYPQHPSMNS----PQIQQMHRYDMAGLQY-PMMST-AQTYMN------AASTYSS 207

Human   336 MAPSATAAAAAAYGQQPATAAAAAAAAAAMSLGPMGSVVKSEPSSPPPAIASHSQRACLGDLRDM 400
            |:|        ||.||         .::||.||.|.||.|:|||||||||.||||||||||||||
Zfish   208 MSP--------AYTQQ---------TSSAMGLGSMASVCKTEPSSPPPAITSHSQRACLGDLRDM 255

Human   401 ISMYLPPGGDAADAASPLPGGRLHGVHQHYQGAGTAVNGTVPLTHI 446
            ||||||||||:||.:| |...|||.||.|||.|||.||||:|||||
Zfish   256 ISMYLPPGGDSADHSS-LQTSRLHSVHPHYQSAGTGVNGTLPLTHI 300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SOX3NP_005625.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 29..48
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 87..140 11/52 (21%)
HMG-box_SoxB 137..212 CDD:438790 71/74 (96%)
SOXp 208..302 CDD:463537 55/93 (59%)
9aaTAD. /evidence=ECO:0000269|PubMed:34342803 399..407 7/7 (100%)
sox3NP_001001811.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35 16/62 (26%)
HMG-box_SoxB 33..108 CDD:438790 71/74 (96%)
SOXp 104..182 CDD:463537 55/93 (59%)
9aaTAD. /evidence=ECO:0000250|UniProtKB:P41225 251..262 10/10 (100%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.