Protein Alignment SOX3 and sox-2

DIOPT Version :10

• Sequence 1: NP_005625.2
• Gene: SOX3 / 6658
• HGNCID: 11199
• Length: 446
• Species: Homo sapiens
• Sequence 2: NP_741836.1
• Gene: sox-2 / 181002
• WormBaseID: WBGene00004949
• Length: 283
• Species: Caenorhabditis elegans
• Alignment Length: 280
• Identity: 107/280 - (38%)
• Similarity: 133/280 - (47%)
• Gaps: 91/280 - (32%)

Human    59 GAPSPPATLAHLLPAPAMYSLLETELKNPVGTPTQAAGTGGPAAPGGAGKSSANAAGGANSGGGS 123
            |...||.:..:|||     ..:..:|.|            ||.:|...||.
 Worm    19 GFHMPPTSSTNLLP-----QSMPDDLSN------------GPDSPDSTGKD-------------- 52

Human   124 SGGASGGGGGTDQDRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGADWKLLTDAEKRPF 188
                    |..:.||||||||||||||||||:|||||||||||||||||||.:||:|::.|||||
 Worm    53 --------GKKNDDRVKRPMNAFMVWSRGQRKKMALENPKMHNSEISKRLGTEWKMLSEQEKRPF 109

Human   189 IDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKDKYSLPSGLLPPGAAAAAAAAAAAAAAASSPVG 253
            |||||||||:||||:||||||||||||::.||:...:|.|
 Worm   110 IDEAKRLRAIHMKEHPDYKYRPRRKTKSINKKNGAPIPFG------------------------- 149

Human   254 VGQRLDTYTH-----VNGW-ANGAY-----------SLVQEQLGYAQPPSMSSPPPPPALPPMHR 301
               .|||.|.     ...| |...|           :.|.:|:.::....:.|.|...:.|
 Worm   150 ---NLDTKTPSYPTLTTNWNATNQYIDQFRFAPYPTTTVMDQIPFSLTYPVHSVPTDNSSP---- 207

Human   302 YDMAGLQYSPMMPPGAQSYM 321
               :..|.|||....|.||:
 Worm   208 ---SQFQPSPMSTNFAGSYL 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOX3	NP_005625.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..48
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..140		8/52 (15%)
		HMG-box_SoxB	137..212	CDD:438790	65/74 (88%)
		SOXp	208..302	CDD:463537	24/110 (22%)
		9aaTAD. /evidence=ECO:0000269|PubMed:34342803	399..407
sox-2	NP_741836.1	HMG-box_SoxB	58..137	CDD:438790	69/78 (88%)