DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SOX2 and Sox100B

DIOPT Version :9

Sequence 1:	NP_003097.1	Gene:	SOX2 / 6657	HGNCID:	11195	Length:	317	Species:	Homo sapiens
Sequence 2:	NP_651839.1	Gene:	Sox100B / 45039	FlyBaseID:	FBgn0024288	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	310	Identity:	83/310 - (26%)
Similarity:	132/310 - (42%)	Gaps:	72/310 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    15 QQTSGGGGG--------------------NSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKM 59
            |:.:.|.||                    |...|:|........:.:||||||||||::..||.|
  Fly    31 QKKAQGQGGRKEDERITTAVMKVLEGYDWNLVQASAKAPTDRKKEHIKRPMNAFMVWAQAARRVM 95

Human    60 AQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDK 124
            :::.|.:.|||:||.||..||.|.:::|:||::.|::||..|.:|||||||:|||| |..:...:
  Fly    96 SKQYPHLQNSELSKSLGKLWKNLKDSDKKPFMEFAEKLRMTHKQEHPDYKYQPRRK-KARVLPSQ 159

Human   125 YTLPGGLLAPG---------------------GNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSN 168
            .:..||  :||                     |...|......|.||:..:    :.:|.|..||
  Fly   160 QSGEGG--SPGPEMTLSATMGSSGKPRSSNSNGQRRAGKGNAAADLGSCAS----TISHANVGSN 218

Human   169 GSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDV-------SALQYNSMTSSQTYMNGSPTYSMS 226
            .|.....:..    ...||:..||.:......:.       :|...:|:|...|..|.:|:.:.:
  Fly   219 SSDVFSNEAF----MKSLNSACAASLMEQSLIETGLDSPCSTASSMSSLTPPATPYNVAPSNAKA 279

Human   227 YSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISM 276
             |....|.:.|..:          |.||..:........:||  |:.:::
  Fly   280 -SAANNPSLLLRQL----------SEPVANAGDGYGVLLEAG--REYVAI 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SOX2	NP_003097.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		7/47 (15%)
		SOX-TCF_HMG-box	40..111	CDD:238684	37/70 (53%)
		SOXp	110..200	CDD:315092	24/110 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..266		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..317
Sox100B	NP_651839.1	SOX-TCF_HMG-box	76..146	CDD:238684	36/69 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810