Protein Alignment SOX2 and Sox21b

DIOPT Version :10

• Sequence 1: NP_003097.1
• Gene: SOX2 / 6657
• HGNCID: 11195
• Length: 317
• Species: Homo sapiens
• Sequence 2: NP_001261829.1
• Gene: Sox21b / 39569
• FlyBaseID: FBgn0042630
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 286
• Identity: 109/286 - (38%)
• Similarity: 137/286 - (47%)
• Gaps: 60/286 - (20%)

Human    34 QKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLR 98
            ::.:.:.:||||||||||||.||||:||:||||||||||||||||||||:|.|||||||||||||
  Fly   241 KRQNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLR 305

Human    99 ALHMKEHPDYKYRPRRKTKTLMKKDKYTLP----------------GGLLAPGGNSMASGVGVGA 147
            |:|||||||||||||||.|.| ::|.|..|                .|..|||  ..|:...:|:
  Fly   306 AMHMKEHPDYKYRPRRKPKAL-RRDGYPYPMPYPSVPVEALRAGITPGYFAPG--PTAAAYHLGS 367

Human   148 GLG---------AGVNQRMDSYA-----HMNGWSNGS-YS----------------MMQDQLGYP 181
            .||         |.::.:||.:|     :::..|..| ||                |.||:....
  Fly   368 HLGQTSTPTTTQATLSGQMDKFALERSSYLSNSSQASAYSAYLDPSVLTKAYFDSKMYQDRAANY 432

Human   182 QHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYM----NGSPTYSMSYSQQGTPGMALGSMGS 242
            .......:||.|....|.......|.......|..:    .||.....:.|........|....:
  Fly   433 AFDISKIYGAQQHAAAHHQQQQQQQQQQQQQQQQLLLSGGGGSGGGGSASSHNNNSSSGLDDRDA 497

Human   243 VVKSEASSSPPVVTSSSHSRAPCQAG 268
            ..:.||..|.|      |..:|...|
  Fly   498 TPQLEAVESKP------HLHSPSDVG 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOX2	NP_003097.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43		0/8 (0%)
		HMG-box_SoxB	39..118	CDD:438790	68/78 (87%)
		SOXp	110..200	CDD:463537	34/136 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..266		6/22 (27%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P41225	272..280
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	297..317
Sox21b	NP_001261829.1	HMG-box_SoxB	246..325	CDD:438790	68/78 (87%)