Protein Alignment SOX2 and Sox14

DIOPT Version :10

• Sequence 1: NP_003097.1
• Gene: SOX2 / 6657
• HGNCID: 11195
• Length: 317
• Species: Homo sapiens
• Sequence 2: NP_476894.1
• Gene: Sox14 / 37822
• FlyBaseID: FBgn0005612
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 299
• Identity: 93/299 - (31%)
• Similarity: 139/299 - (46%)
• Gaps: 63/299 - (21%)

Human    34 QKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLR 98
            :|:||..:|||||||||||:.:|||:.:..|.:||:||||.||..|:|||:.:|:|:|.||::||
  Fly   180 KKHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLR 244

Human    99 ALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHM 163
            .|||.|:|:|||||::         |.|...|.|.|                   ||..|.....
  Fly   245 KLHMIEYPNYKYRPQK---------KQTRSPGSLKP-------------------NQDADGCEAR 281

Human   164 NGWSNGSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGS------PT 222
            |..:|.:.|:..          |..:|........:...|..|  |.::|:...|.|      |.
  Fly   282 NDTTNNNNSLTT----------LAINGTTTAGRKSKRSTSTCQ--SGSASKRLRNDSGDTSSKPK 334

Human   223 YSM---SYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSS-------HSR---APCQAGD-LRDM 273
            |.:   |..|..:..:.|.|..:::..::|...|:.|.|:       ||.   .|.::.: |.::
  Fly   335 YEVKMESAEQLNSADIILPSADNLISYQSSEYLPLSTLSNADCDEKLHSELSSGPLESRENLSEV 399

Human   274 ISMYLP---GAEVPEPAAPSRLHMSQHYQSGPVPGTAIN 309
            ::.:||   |.........|.|..|||.||.|..|...|
  Fly   400 VNRFLPLFLGGNEDSQLGVSSLTQSQHNQSDPTAGLMDN 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOX2	NP_003097.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43		3/8 (38%)
		HMG-box_SoxB	39..118	CDD:438790	44/78 (56%)
		SOXp	110..200	CDD:463537	16/89 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..266		7/32 (22%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P41225	272..280		2/10 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	297..317		6/13 (46%)
Sox14	NP_476894.1	HMG-box_SoxC	186..261	CDD:438838	44/83 (53%)