Protein Alignment SOS2 and Sos

DIOPT Version :10

• Sequence 1: XP_047287669.1
• Gene: SOS2 / 6655
• HGNCID: 11188
• Length: 1397
• Species: Homo sapiens
• Sequence 2: NP_476597.2
• Gene: Sos / 34790
• FlyBaseID: FBgn0001965
• Length: 1596
• Species: Drosophila melanogaster
• Alignment Length: 1455
• Identity: 611/1455 - (41%)
• Similarity: 840/1455 - (57%)
• Gaps: 206/1455 - (14%)

Human     8 YEFFSEENSPKWRGLLVSALRKMESRFFARLGCSGAILAHCNLHLSGSSDSPASASRVAGTTGVC 72
            |:|...||:.:||||...:|:|
  Fly    58 YDFTKCENAARWRGLFTPSLKK------------------------------------------- 79

Human    73 HHAQVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQ-PRTVQDVEERVQKTFPHPIDKWAIAD 136
                |.|||||.::|.|::|.|:|:|..:||..||... |.:||||||:|.|:||.|||:||:.:
  Fly    80 ----VLEQVHPRVTAKEDALLYVEKLCLRLLAMLCAKPLPHSVQDVEEKVNKSFPAPIDQWALNE 140

Human   137 AQSAIEKRKRRNPLLLPVDKIHPSL-KEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIR 200
            |:..|..:||::  :||.:|:|..| |:||.||:|..||.::|||||||||||||:||:||..|.
  Fly   141 AKEVINSKKRKS--VLPTEKVHTLLQKDVLQYKIDSSVSAFLVAVLEYISADILKMAGDYVIKIA 203

Human   201 HYEISQQDIKVSMCADKPLVTTFYSASMSLFQIPHVLMDMFDQDDIGLVSLCEDEPSSSGELNYY 265
            |.||:::||:|.|.||:                  |||||.:|.:..::......|:......|.
  Fly   204 HCEITKEDIEVVMNADR------------------VLMDMLNQSEAHILPSPLSLPAQRASATYE 250

Human   266 DLVRTEIAEERQYLRELNMIIKVFRE---AFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGLIE 327
            :.|:..|.:|:||.|:|:|||:||||   ..:||     |.::|.|||||.||:|:||.|||.:|
  Fly   251 ETVKELIHDEKQYQRDLHMIIRVFREELVKIVSD-----PRELEPIFSNIMDIYEVTVTLLGSLE 310

Human   328 DTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQSIAD 392
            |.:||:.|.|. |..|||||:|||.:.||.|:..:.|:.|....:..|.|:::|. |....:...
  Fly   311 DVIEMSQEQSA-PCVGSCFEELAEAEEFDVYKKYAYDVTSQASRDALNNLLSKPG-ASSLTTAGH 373

Human   393 GFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQY 457
            ||::||:|.||:|:|||:.|.:.||:.:|.||..|..|:|.|...|....|..|...::::....
  Fly   374 GFRDAVKYYLPKLLLVPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQGLLHPLHCDLEKVMASL 438

Human   458 SPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAK--- 519
            |..|:.  ||    |.::| :.|||::..|:|..::.||.||:||.|||||.|..|:::|:.
  Fly   439 SKERQV--PV----SGRVR-RQLAIERTRELQMKVEHWEDKDVGQNCNEFIREDSLSKLGSGKRI 496

Human   520 -HERHIFLFDGLMISCKPN-HGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSK 582
             .||.:|||||||:.||.| ..||...|.::.:||||||:.||::.|.|:.|:.:.|::|||..:
  Fly   497 WSERKVFLFDGLMVLCKANTKKQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLKNSFELAPR 561

Human   583 DENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEE 647
            .:..|:..||:|:.|::|||.|:.:..:|.|||.|||:|...|.:.|||:||||:|:|.|.||.:
  Fly   562 MQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPEIYKFAVPDSGD 626

Human   648 NIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFE 712
            |||.|:  :..:|:|:|||.|:.|||||||||:||||.||||||||||.||.||:||.||:|||.
  Fly   627 NIVLEE--RESAGVPMIKGATLCKLIERLTYHIYADPTFVRTFLTTYRYFCSPQQLLQLLVERFN 689

Human   713 IPEPEPTDADKLAIEKG-----------EQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYD 766
            ||:|.....|......|           :.....|.||:|||||||||.|:|||.||||:|||||
  Fly   690 IPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYD 754

Human   767 FERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKP 831
            ||:|..|||:|.:|:..|.||:|:|||:|:.||::||.:.:.:.......:...|||||.|:|.|
  Fly   755 FEKDPMLLEKLLNFLEHVNGKSMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVP 819

Human   832 GQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTL 896
            .  :...|:||||:|:||||||||.::|:.|:|||||||.|||:|||:.||||||:::||||:|.
  Fly   820 N--DEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTR 882

Human   897 WFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKR 961
            |.||.|.||||:|||:|::.|.||::.|..:||||||:|.||:|:.:.|||||..||:.|.||.|
  Fly   883 WIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYR 947

Human   962 KILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRK 1026
            |.|:|..|||.||.|||..:|:|||||||||||.||||||..||||.|.|  ...:|||||||||
  Fly   948 KFLEECRELSDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLL--ANTELINFSKRRK 1010

Human  1027 VAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFP 1091
            ||||.|||||||||||||..|..:|:|||.|:|....|:|:.:|||:|:||.||||.||..|:||
  Fly  1011 VAEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKFP 1075

Human  1092 RK-STFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPS 1155
            || ....||||||:|.  |...|:.:            .|:|.|..:.....:..|..||..|.|
  Fly  1076 RKWPHIPLKSPGIKPR--RQNQTNSS------------SKLSNSTSSVAAAAAASSTATSIATAS 1126

Human  1156 TPPVSASSDLSVFLDVDLNSSCG-------------SNSIFAPVLLPHSKSFFSSCGSLHKLSE- 1206
            .|.:.|||.:........|:..|             :.|:||||::|...:...|....|..::
  Fly  1127 APSLHASSIMDAPTAAAANAGSGTLAGEQSPQHNPHAFSVFAPVIIPERNTSSWSGTPQHTRTDQ 1191

Human  1207 ---EPLIPPPLPPRKKFDHDASNSKGNMKSDDD-----PPAIPPRQPPP--PKVKPRVPVPTGAF 1261
               |..:|.|..|:|...|..:|:...:.|...     .||:|...||.  |...|        |
  Fly  1192 NNGEVSVPAPHLPKKPGAHVWANNNSTLASASAMDVVFSPALPEHLPPQSLPDSNP--------F 1248

Human  1262 DGPLHSPPPPPPR---DPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDIST---- 1319
            .....:||.|.|:   .|..:|..    |.|.|     ..:|..|. |....:..|..:||
  Fly  1249 ASDTEAPPSPLPKLVVSPRHETGN----RSPFH-----GRMQNSPT-HSTASTVTLTGMSTSGGE 1303

Human  1320 --CP-----NS-----PSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPR------------ 1360
              |.     ||     |...|.:|...||     ::::....|.|  ||:|||
  Fly  1304 EFCAGGFYFNSAHQGQPGAVPISPHVNVP-----MATNMEYRAVP--PPLPPRRKERTESCADMA 1361

Human  1361 -QNSSPHLPKLPPKTYKRELSHPPL 1384
             :..:|..|.|||:  ..|||.||:
  Fly  1362 QKRQAPDAPTLPPR--DGELSPPPI 1384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOS2	XP_047287669.1	HFD_SOS1_rpt1	18..142	CDD:467039	39/124 (31%)
		HFD_SOS1_rpt2	151..219	CDD:467040	40/68 (59%)
		RhoGEF	264..451	CDD:238091	80/189 (42%)
		PH_SOS	502..608	CDD:269963	48/110 (44%)
		RasGEFN	660..804	CDD:214571	89/154 (58%)
		RasGEF	839..1078	CDD:238087	152/238 (64%)
Sos	NP_476597.2	HFD_SOS1_rpt1	68..145	CDD:467039	39/123 (32%)
		HFD_SOS1_rpt2	153..227	CDD:467040	45/91 (49%)
		RhoGEF	249..432	CDD:238091	80/189 (42%)
		PH_SOS	476..586	CDD:269963	48/109 (44%)
		RasGEFN	637..791	CDD:214571	88/153 (58%)
		RasGEF	825..1062	CDD:238087	152/238 (64%)
		PHA03247	<1197..1502	CDD:223021	55/215 (26%)