DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SOS1 and Sos

DIOPT Version :9

Sequence 1:	NP_005624.2	Gene:	SOS1 / 6654	HGNCID:	11187	Length:	1333	Species:	Homo sapiens
Sequence 2:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster

Alignment Length:	1507	Identity:	619/1507 - (41%)
Similarity:	853/1507 - (56%)	Gaps:	235/1507 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     8 YEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLC-QAQPRSASDVE 71
            |:|...|||.:||||..|:||||..||||.:.:.:|||.|||:|.|:||.||| :..|.|..|||
  Fly    58 YDFTKCENAARWRGLFTPSLKKVLEQVHPRVTAKEDALLYVEKLCLRLLAMLCAKPLPHSVQDVE 122

Human    72 ERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLL-KEVLGYKIDHQVSVYIVAVLE 135
            |:|.||||.|||:||:.:|:..|..:||::  .||.||:|.|| |:||.||||..||.::|||||
  Fly   123 EKVNKSFPAPIDQWALNEAKEVINSKKRKS--VLPTEKVHTLLQKDVLQYKIDSSVSAFLVAVLE 185

Human   136 YISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDVEDINILSLTDEEPSTSGEQT 200
            ||||||||:.|:||..|.|.||||:||:|.|.||:|||||.:|  .:.:||......|:.....|
  Fly   186 YISADILKMAGDYVIKIAHCEITKEDIEVVMNADRVLMDMLNQ--SEAHILPSPLSLPAQRASAT 248

Human   201 YYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFS-ANDVENIFSRIVDIHELSVKLLGHIE 264
            |.:.||..:.:.:||.|:|::||:||||..|   |:.| ..::|.|||.|:||:|::|.|||.:|
  Fly   249 YEETVKELIHDEKQYQRDLHMIIRVFREELV---KIVSDPRELEPIFSNIMDIYEVTVTLLGSLE 310

Human   265 DTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDILRPGFHDRFLSQLSKPGAALYLQSIGE 329
            |.:||:.|.|. |.||||||:|||...||.|:.||.|:......|...:.||||||: .|.:.|.
  Fly   311 DVIEMSQEQSA-PCVGSCFEELAEAEEFDVYKKYAYDVTSQASRDALNNLLSKPGAS-SLTTAGH 373

Human   330 GFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEKICSKS 394
            ||::||:|.||:|||.|:.|...||:.:|.|::.|..|:|.|..:|....|..:...:||:.: |
  Fly   374 GFRDAVKYYLPKLLLVPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQGLLHPLHCDLEKVMA-S 437

Human   395 LAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAK--- 456
            |:|.|....:.|.      .:||||::..|:|..::.||.||:||.|||||.|.:|:::|:.
  Fly   438 LSKERQVPVSGRV------RRQLAIERTRELQMKVEHWEDKDVGQNCNEFIREDSLSKLGSGKRI 496

Human   457 -HERHIFLFDGLMICCKSN-HGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILK 519
             .||.:|||||||:.||:| ..|....||:..:||||||:|||:|.|||:.|:::.|::||:..:
  Fly   497 WSERKVFLFDGLMVLCKANTKKQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLKNSFELAPR 561

Human   520 DENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEE 584
            .:..::.:||:|:.|::|||.|:.:..:|.|:|.||..:...|::..:|:||.::|:||.|||.:
  Fly   562 MQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPEIYKFAVPDSGD 626

Human   585 NIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFE 649
            ||:.||  :..||:|:||..|:.|||||||||:||||.||||||||||.||.||:||.|::|||.
  Fly   627 NIVLEE--RESAGVPMIKGATLCKLIERLTYHIYADPTFVRTFLTTYRYFCSPQQLLQLLVERFN 689

Human   650 IPEPEPTEADR-------IAIENGDQPLS----AELKRFRKEYIQPVQLRVLNVCRHWVEHHFYD 703
            ||:|.....|.       :....||:...    .:.||:||||:||||.|||||.||||:|||||
  Fly   690 IPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYD 754

Human   704 FERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRP 768
            ||:|..||:::..|:..|.||:|:|||:|:.||:|||.....:.......:...||.:|.|:|.|
  Fly   755 FEKDPMLLEKLLNFLEHVNGKSMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVP 819

Human   769 GHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTL 833
            .  :...||||||:|:||||||||.::|:.|:|||||||.|||:|||:.||||||:::||||:|.
  Fly   820 N--DEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTR 882

Human   834 WFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQK 898
            |.||.|.|.||.|||:|::.|.||::.|..|||||||:|.:|:||.::.||||..||:.:|.|.:
  Fly   883 WIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYR 947

Human   899 KILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRK 963
            |.|||..|||:||.|||..:|||||||||||||.||||||..|||||::|.  ..||||||||||
  Fly   948 KFLEECRELSDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLLA--NTELINFSKRRK 1010

Human   964 VAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFP 1028
            ||||.|||||||||||||..||.|::|||.|:|.....:|:.:|||:|:||.||||..|.:|:||
  Fly  1011 VAEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKFP 1075

Human  1029 KKYSY-PLKSPGVRP-------------------------------------------------- 1042
            :|:.: ||||||::|
  Fly  1076 RKWPHIPLKSPGIKPRRQNQTNSSSKLSNSTSSVAAAAAASSTATSIATASAPSLHASSIMDAPT 1140

Human  1043 ---SNPRPGTMRHPTPLQQEPRKISYSR---IPESETESTASAPNSPRT--------------PL 1087
               :|...||:......|..|...|...   |||..|.|.:..|...||              |.
  Fly  1141 AAAANAGSGTLAGEQSPQHNPHAFSVFAPVIIPERNTSSWSGTPQHTRTDQNNGEVSVPAPHLPK 1205

Human  1088 TPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISLTKGTDEVPVPPP 1152
            .|.....|::.:.:.|.          |:.|.||......|.|..:...|......|:..|.|.|
  Fly  1206 KPGAHVWANNNSTLASA----------SAMDVVFSPALPEHLPPQSLPDSNPFASDTEAPPSPLP 1260

Human  1153 ---VPPRR----------RPESAPAESSPSKIM--------------------SKHLDSPPAIPP 1184
               |.||.          |.:::|..|:.|.:.                    |.|...|.|:|
  Fly  1261 KLVVSPRHETGNRSPFHGRMQNSPTHSTASTVTLTGMSTSGGEEFCAGGFYFNSAHQGQPGAVP- 1324

Human  1185 RQPTSKAYSPRYSISDRTSISDPPESPPLLPPREPVRT------------PDVFSSSPL--HLQP 1235
                   .||..::...|:: :....||.||||...||            ||..:..|.  .|.|
  Fly  1325 -------ISPHVNVPMATNM-EYRAVPPPLPPRRKERTESCADMAQKRQAPDAPTLPPRDGELSP 1381

Human  1236 PPLGKKSDH------------------GNA--FFPNSPS-------------PFTPPPPQTPS-- 1265
            ||:..:.:|                  ||:  ..||:.|             ..|..|.|..:
  Fly  1382 PPIPPRLNHSTGISYLRQSHGKSKEFVGNSSLLLPNTSSIMIRRNSAIEKRAAATSQPNQAAAGP 1446

Human  1266 ----------PHGTRRHLPSP------------PLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPK 1308
                      ...|...||.|            |||..:...|...|..|...::|.:..:|..:
  Fly  1447 ISTTLVTVSQAVATDEPLPLPISPAASSSTTTSPLTPAMSPMSPNIPSHPVESTSSSYAHQLRMR 1511

Human  1309 TYKREHTHPSMH 1320
            ..:::.|||:::
  Fly  1512 QQQQQQTHPAIY 1523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SOS1	NP_005624.2	Histone	63..169	CDD:333859	62/106 (58%)
		RhoGEF	204..389	CDD:214619	80/185 (43%)
		PH_SOS	439..545	CDD:269963	49/110 (45%)
		RasGEFN	597..741	CDD:214571	86/154 (56%)
		RasGEF	776..1015	CDD:238087	153/238 (64%)
		PTZ00449	<1018..1319	CDD:185628	97/475 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1103		30/154 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1333		60/296 (20%)
Sos	NP_476597.2	Histone	90..216	CDD:278551	74/127 (58%)
		H2A	155..>196	CDD:305064	28/40 (70%)
		RhoGEF	249..432	CDD:238091	81/187 (43%)
		PH_SOS	476..586	CDD:269963	49/109 (45%)
		PH	482..587	CDD:278594	44/104 (42%)
		RasGEFN	637..791	CDD:214571	85/153 (56%)
		RasGEF	825..1062	CDD:238087	153/238 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	239	1.000	Domainoid score	I2281
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4117
Inparanoid	1	1.050	1040	1.000	Inparanoid score	I268
Isobase	1	0.950	-	0	Normalized mean entropy	S3092
OMA	1	1.010	-	-		QHG45786
OrthoDB	1	1.010	-	-		D262477at33208
OrthoFinder	1	1.000	-	-		FOG0002651
OrthoInspector	1	1.000	-	-		otm42213
orthoMCL	1	0.900	-	-		OOG6_101209
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	1	1.000	-	-		X2024
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.960