DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SORL1 and yl

DIOPT Version :9

Sequence 1:	NP_003096.2	Gene:	SORL1 / 6653	HGNCID:	11185	Length:	2214	Species:	Homo sapiens
Sequence 2:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster

Alignment Length:	1928	Identity:	438/1928 - (22%)
Similarity:	664/1928 - (34%)	Gaps:	666/1928 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   636 SDERGNECL------LGHKTVFKRRT---------PHATCFNGEDFDRPVVVSNCSCTREDYECD 685
            |||||  ||      .|......|.|         .|:.|.:|.| :..:..|...|..:  :|.
  Fly   257 SDERG--CLNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSD-ETDLCHSKPDCDAK--KCA 316

Human   686 FGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYR--------------KISGDTC 736
            .|.|         |...|....:.:     ||        :|:|              |...|.|
  Fly   317 LGAK---------CHMMPASGAECF-----CP--------KGFRLAKFEDKCEDVDECKEQDDLC 359

Human   737 SGG------------DVEARLEGELVPCPLA-----EENEFILYAVRKSI----YRYDLASGATE 780
            |.|            |....|:.:...|...     |:...:||..:.:|    .|.|.......
  Fly   360 SQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVY 424

Human   781 QLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNG-STGQEVIINSGLETVEALAFEPLSQ 844
            |: ...|...:.:.:|..|  :||:::..:....:..|| .:..|:::.|||:..|.||.:.|:|
  Fly   425 QV-AGNLSKVIGVAYDGSH--IYWTNIQNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQ 486

Human   845 LLYWVDAGFKKIEVANPDGDFRLTIVNSSVL-----DRPRALVLVPQEGVMFWTDWGDLKPGIYR 904
            .:|:.|...:.|.|.:.||      :|.:||     .:||:|.:.||:|:|||||||: ||.|.|
  Fly   487 NIYFSDNIMRHIAVCSNDG------LNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGE-KPMIGR 544

Human   905 SNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDN-LPHPYAI 966
            ::||||.:..:||::::|||||::|  .|.|||.||.|..::.:...|..|..:||. |.|||.:
  Fly   545 ASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHPYGL 609

Human   967 AVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGS-NACVPRPCSLLC 1030
            |:|::::||.||:..|:....|:||....|||...| :..:.|::..|...| :.|....||.||
  Fly   610 AIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRT-IYAVHIYHPAKQPNSPHGCENATCSHLC 673

Human  1031 LPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQL--KNNTCVKQEN----------------- 1076
            |...        ||        .|...|.||.|.:|  .:..|:..|.
  Fly   674 LLAE--------PE--------IGGHSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEH 722

Human  1077 --------------TCLRNQ--YRCSNGNCINSIWWCDFDND---------------------CG 1104
                          .||.|:  |...||:.|.:      |||                     .|
  Fly   723 TAFGRHQVSKSYTLPCLINEMVYNRINGSLIIA------DNDQRLILEFQPESHESNVLVRSNLG 781

Human  1105 DMS--------------DERNCPTTICDLDTQFRC-------QE----------SGTC------- 1131
            ::|              |.......:..|.|:.|.       ||          .|..
  Fly   782 NVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYVVLKAK 846

Human  1132 -------IPLSYKCD----LEDDCGDN---------------SDES------------HC----- 1153
                   ||||.|.:    .|||.||:               ||..            |.
  Fly   847 RHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIFRG 911

Human  1154 ----------------------------------------------------------------- 1153

  Fly   912 KLRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLA 976

Human  1154 -------EMHQCRSDEYNCSSGMCI-----RSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQC 1206
                   |.|.|:.....||. :|:     .|..:|......||..:.....|:  .||   |:|
  Fly   977 ASSPVGQESHPCQQQNGGCSH-ICVGEGPYHSICLCPAGFVYRDAGNRTCVEAL--DCE---FRC 1035

Human  1207 RNGHCIPQRWACDGDTDCQDGSDEDPVNCEKK--------C--NGFRCPNG-TCIPSSKHCDGLR 1260
            .:|.|:.....|:|..||.|.|||  :||:::        |  |.|.|.:| .|:...:.||..:
  Fly  1036 HSGECLTMNHRCNGRRDCVDNSDE--MNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRK 1098

Human  1261 DCSDGSDEQHCEPL-----CTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPE 1320
            ||.|.|||||||..     | |.....|.| .:|:..|:||||...|.|.|||...        |
  Fly  1099 DCHDHSDEQHCEKFDKSKKC-HVHQHGCDN-GKCVDSSLVCDGTNDCGDNSDELLC--------E 1153

Human  1321 FHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEAN-CENPTEAPNCSRYFQFRCENGHCIPN 1384
            ....|:...|||.:|.||:..|:|||..||.|.|||.: |.:.:..|:..     ||..|.|:..
  Fly  1154 ATSRCEPGMFQCGSGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQ-----RCLLGQCLDR 1213

Human  1385 RWKCDRENDCGDWSDEKDCG-DSHILPFSTPGPSTCLPNYYRCSSG--TCVMDTWVCDGYRDCAD 1446
            ...||..|||||.|||.:|| ||..:..|      |..:.|:|:|.  .|:..|..|:|..:|..
  Fly  1214 SLVCDGHNDCGDKSDELNCGTDSSTMNIS------CAEDQYQCTSNLKICLPSTVRCNGTTECPR 1272

Human  1447 GSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCP---- 1507
            |.||..|   .:|           |..:||:|...:.||....||||.:||.||.||.:|.
  Fly  1273 GEDEADC---GDV-----------CSIYEFKCRSGRECIRREFRCDGQKDCGDGSDELSCELEKG 1323

Human  1508 ----------THSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDE-KACSDELTVYKVQNL 1561
                      :.|:.:|....|.|:||| |:.||..|:.|.||::..|| ..|:
  Fly  1324 HHNQSQIQPWSTSSRSCRPHLFDCQDGE-CVDLSRVCNNFPDCTNGHDEGPKCA----------- 1376

Human  1562 QWTADFSGDVTLTWMRPKKMPSASCVYNVY--YRVVGESIWKTLETHSNKTNTVLKVLKPDTTYQ 1624
              ||..|...........:...|..|.:.:  ||:..:.            .:.|.:      .:
  Fly  1377 --TACRSASGRQVCQHKCRATPAGAVCSCFDGYRLDADQ------------KSCLDI------DE 1421

Human  1625 VKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGVIVGHWAPPIHTHGLIREYIVE 1689
            .:.|..|.....||                               :|.:....|...::|:..|.
  Fly  1422 CQEQQPCAQLCENT-------------------------------LGGYQCQCHADFMLRQDRVS 1455

Human  1690 YS--RSGSKMWASQRAASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSITTIKGKVIPPPD 1752
            ..  :||:.:     ..|:|.|::||....: .:.||         ||.:.|..|
  Fly  1456 CKSLQSGATL-----LFSSFNEVRNLSEQPV-MLNVA---------WSANDSRIT---------- 1495

Human  1753 IHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRGSILSHKVGNLTAHTS-- 1815
                       .|.|.|                   |:|               :|..:|...
  Fly  1496 -----------GFDLAM-------------------HRQ---------------MGYFSAEDEGI 1515

Human  1816 -YEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQTAVECTW-TGPRNVVYGI--FYAT 1876
             |:|....|            |:.|.:..|||         |.:...| ||...|:.|.  ..|.
  Fly  1516 VYQIDLQTK------------VIVRALGLPAP---------TKLSVDWVTGNVYVLSGAQEIQAC 1559

Human  1877 SFLDL-------YRNPKSLTTSLHNKTVIVSKDEQYLFLVRVVVPYQGPSSDYVVVKMIPDSRLP 1934
            ||:..       .::|:      |.|.:.|......:|.:.:.....|.:|..:.:..:..||
  Fly  1560 SFVGRMCGRIVHVKSPR------HVKHLAVDGYHARIFYIVIRTEGYGQTSSEIHMARLDGSR-- 1616

Human  1935 PRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAVAVKDLIRKTDRSYKVKSRNSTVEYTLNKLEPG 1999
             |.:.:..:......:..:     |.|.|||.|         |:..:...|   :.|.| |..|.
  Fly  1617 -RDMLLQRSESFMTALTTD-----PHQQLLYFV---------DQHMRTLER---ISYRL-KTGPM 1662

Human  2000 GKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKHFNESRGYEIHMF 2064
            .:..|::|..|            :|..|..|.:...|..::           :.......:..::
  Fly  1663 RRPEIMLQKSN------------ALMHPSGLSVYENNAFIV-----------NLGSVEAVQCALY 1704

Human  2065 DSAM--NITAYLGNTTDNFF--------KISN-LKMGHNYTFTVQA----RCLFGNQICGEPAIL 2114
            .|.:  .|:..:.|..|...        |.|: ....|.:...:||    .|:.||::..|....
  Fly  1705 GSRICHKISINVLNAQDIVVAGRSRQPQKASHPCAHAHCHGLCLQADYGYECMCGNRLVAEGERC 1769

Human  2115 LYDELGSGADASATQAARSTDVAAV---------VVPILFLILLSLGVGFAILYTKHRRLQSSFT 2170
            .:   |||.:.:...|..|.::...         ::.:..|...||..|...:|.::|  |...|
  Fly  1770 PH---GSGNEVAVLGAVNSLELEHEHEQNGHFHWLMALFVLAAGSLIAGLGYMYYQYR--QRGHT 1829

Human  2171 AF-ANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMV 2212
            .. .|.|:.:.|.:.   .|.....:.|.|....||:.:...|
  Fly  1830 DLNINMHFQNPLATL---GGTKAFLEHERAEAGVGFTTETGTV 1869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SORL1	NP_003096.2	Cell attachment site. /evidence=ECO:0000255	63..65
		VPS10	124..753	CDD:214740	32/157 (20%)
		BNR 1	136..147
		BNR 2	232..243
		BNR 3	441..452
		BNR 4	521..532
		BNR 5	562..573
		LY	780..821	CDD:214531	8/41 (20%)
		LDL-receptor class B 1	800..843		11/43 (26%)
		LY	824..866	CDD:214531	15/41 (37%)
		LDL-receptor class B 2	844..887		14/47 (30%)
		LY	868..910	CDD:214531	22/46 (48%)
		LDL-receptor class B 3	888..932		24/45 (53%)
		Ldl_recept_b	890..929	CDD:278487	22/38 (58%)
		LY	913..953	CDD:214531	16/41 (39%)
		LDL-receptor class B 4	933..970		15/37 (41%)
		LDL-receptor class B 5	971..1013		13/41 (32%)
		LDLa	1078..1112	CDD:238060	13/70 (19%)
		LDLa	1120..1153	CDD:238060	17/94 (18%)
		Ldl_recept_a	1157..1192	CDD:278486	8/39 (21%)
		LDLa	1198..1230	CDD:197566	12/31 (39%)
		LDLa	1240..1271	CDD:238060	14/31 (45%)
		LDLa	1281..1308	CDD:197566	11/26 (42%)
		LDLa	1325..1359	CDD:238060	17/34 (50%)
		LDLa	1373..1403	CDD:238060	14/29 (48%)
		LDLa	1419..1453	CDD:238060	12/35 (34%)
		LDLa	1471..1506	CDD:238060	16/34 (47%)
		LDLa	1513..1546	CDD:197566	13/32 (41%)
		FN3	1557..>1628	CDD:238020	8/72 (11%)
		FN3	1651..1742	CDD:238020	16/92 (17%)
		FN3	1749..1829	CDD:214495	10/82 (12%)
		FN3	1934..2021	CDD:238020	16/86 (19%)
		FN3	2025..2112	CDD:238020	16/101 (16%)
		Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000305\|PubMed:16531402	2161..2164		0/2 (0%)
		Endocytosis signal. /evidence=ECO:0000255	2172..2177		1/5 (20%)
		Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000269\|PubMed:17646382	2190..2214		5/23 (22%)
		Required for interaction with GGA1 and GGA2. /evidence=ECO:0000269\|PubMed:11821067	2201..2214		3/12 (25%)
		DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000269\|PubMed:20015111	2208..2212		0/3 (0%)
yl	NP_996433.1	LDLa	90..124	CDD:238060
		LDLa	131..166	CDD:238060
		LDLa	184..216	CDD:238060
		LDLa	227..262	CDD:238060	5/6 (83%)
		LDLa	271..302	CDD:238060	7/31 (23%)
		FXa_inhibition	352..387	CDD:291342	7/34 (21%)
		Ldl_recept_b	442..482	CDD:278487	12/41 (29%)
		LY	466..508	CDD:214531	15/47 (32%)
		Ldl_recept_b	529..569	CDD:278487	23/40 (58%)
		LY	553..595	CDD:214531	16/41 (39%)
		LY	596..637	CDD:214531	16/40 (40%)
		FXa_inhibition	669..700	CDD:291342	13/46 (28%)
		LY	774..815	CDD:214531	5/40 (13%)
		LDLa	1032..1062	CDD:238060	13/34 (38%)
		LDLa	1074..1109	CDD:238060	15/34 (44%)
		LDLa	1118..1152	CDD:238060	15/35 (43%)
		LDLa	1157..1189	CDD:197566	15/31 (48%)
		LDLa	1198..1232	CDD:238060	15/38 (39%)
		LDLa	1243..1279	CDD:238060	12/35 (34%)
		LDLa	1283..1318	CDD:238060	16/34 (47%)
		LDLa	1340..1371	CDD:197566	13/31 (42%)
		FXa_inhibition	1388..1416	CDD:291342	4/39 (10%)
		EGF_CA	1418..1452	CDD:214542	7/70 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810