DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SOD1 and Sod1

DIOPT Version :9

Sequence 1:	NP_000445.1	Gene:	SOD1 / 6647	HGNCID:	11179	Length:	154	Species:	Homo sapiens
Sequence 2:	NP_476735.1	Gene:	Sod1 / 39251	FlyBaseID:	FBgn0003462	Length:	153	Species:	Drosophila melanogaster

Alignment Length:	154	Identity:	94/154 - (61%)
Similarity:	113/154 - (73%)	Gaps:	2/154 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHF 65
            |..|||||:.||  .:|.:.|||:.|..||||.|.:.||.:||||||||||||||.||.|:||||
  Fly     1 MVVKAVCVINGD--AKGTVFFEQESSGTPVKVSGEVCGLAKGLHGFHVHEFGDNTNGCMSSGPHF 63

Human    66 NPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKG 130
            ||..::||.|.||.||:|||||:.|..|....|:|.||.|:|.|...|||||:|||..|||||:|
  Fly    64 NPYGKEHGAPVDENRHLGDLGNIEATGDCPTKVNITDSKITLFGADSIIGRTVVVHADADDLGQG 128

Human   131 GNEESTKTGNAGSRLACGVIGIAQ 154
            |:|.|..|||||:|:.|||||||:
  Fly   129 GHELSKSTGNAGARIGCGVIGIAK 152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SOD1	NP_000445.1	Cu-Zn_Superoxide_Dismutase	3..147	CDD:238186	86/143 (60%)
Sod1	NP_476735.1	Cu-Zn_Superoxide_Dismutase	2..150	CDD:412632	90/149 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142478
Domainoid	1	1.000	178	1.000	Domainoid score	I3582
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H392
Inparanoid	1	1.050	194	1.000	Inparanoid score	I3842
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61834
OrthoDB	1	1.010	-	-		D1574423at2759
OrthoFinder	1	1.000	-	-		FOG0000641
OrthoInspector	1	1.000	-	-		oto88569
orthoMCL	1	0.900	-	-		OOG6_101013
Panther	1	1.100	-	-	O	PTHR10003
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1372
SonicParanoid	1	1.000	-	-		X1078
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940