DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SNX2 and SH3PX1

DIOPT Version :9

Sequence 1:	NP_003091.2	Gene:	SNX2 / 6643	HGNCID:	11173	Length:	519	Species:	Homo sapiens
Sequence 2:	NP_648348.1	Gene:	SH3PX1 / 39136	FlyBaseID:	FBgn0040475	Length:	565	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	109/577 - (18%)
Similarity:	204/577 - (35%)	Gaps:	158/577 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    15 PTDFEDLEDGEDLFTSTVSTLESSPSSPEPAS---LPAEDISANSNGPKPTEVVLDD--DREDLF 74
            |..:.::....:....:.|...|.|..|:|.:   ||..|.:|:.:|....:.  ||  |..|.:
  Fly    53 PAAYVEVMSAAEAQKLSASGATSVPQVPDPFASPPLPRYDQTADDDGSNWDDE--DDWSDDNDTY 115

Human    75 AE-----------------ATEEVSLDSPEREPILSSEPSPAVTPVTPTTLIAPRIE----SKSM 118
            :|                 .:...|....:..||..::.:.::..|...|..|..::    :||.
  Fly   116 SEIGPGGQKSAGQSARAGGLSHSTSDYDNKHLPIAPNDDTQSLASVAGGTGAAGTVKKGMFAKSS 180

Human   119 SAPVI-FDRSREEIEEEANGDIFDIE--------------IGVSDPEKVG--DGMNAYMAYRVTT 166
            .:.:: ...::|:|.|.....|..:|              :.|:.|:|..  .||..::||::|.
  Fly   181 DSYILGLSSTKEKIPECEMAYITQVEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFIAYQLTP 245

Human   167 KTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSSSTEF 231
                   |.:..||.||:..|..||.:|..|:..:.  |||.|:|.|.|..:          .:|
  Fly   246 -------SFNNISVSRRYKHFDWLHERLVDKFCLIP--VPPLPDKQISGRYE----------EQF 291

Human   232 VEKRRAALERYLQRTVKHPTL--------------------------------------LQDPDL 258
            ||.||..|:.::....:||.:                                      :..||
  Fly   292 VEHRRVQLQEFVDWVCRHPVISKCEVWYHFLTCRDEKIWKSGKRKAERDPYMGVNYCLAISPPD- 355

Human   259 RQFLESSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKL 323
            :..|.|.     |:.|...|...:..::.|...:|.::..|.:..  ..:.:::|:.:...|..|
  Fly   356 KNLLHSK-----VDAQVELGTQFIHSMDVAVRNLNNISNDMAKRS--MSQSKKEFQRIGDGLSDL 413

Human   324 HVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYM 388
               .:||....:......|               ..||.::.::..:...|.|...:|...|:..
  Fly   414 ---AKALAIDERRAPTRNA---------------VPLSESVGRIGGIFIGIGQAFGDQPKHDWIP 460

Human   389 FSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIREW 453
            .|:.|..|..::.....:|.......||.:|.:     |...|.:|   |.|
  Fly   461 LSDRLHIYRGVLNCFPDIFSTHKGAIQKRKDCE-----KLAGEGRM---NNP------------- 504

Human   454 EAKVQQGERDFEQISKTIRKEVGRFEKER-------VKDFKTVIIKYLESLVQTQQQ 503
              ::....|..:.:|.|:..|:..|:.||       :|:|....||:.:.:|...|:
  Fly   505 --QLHDVNRRTDVVSYTVLAELTHFKSERDTHLKHTLKNFIAEQIKFYQGVVARLQE 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNX2	NP_003091.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..104		19/110 (17%)
		Sorting_nexin	2..134	CDD:367612	26/145 (18%)
		PX_SNX2	142..265	CDD:132815	37/176 (21%)
		Interaction with RhoG. /evidence=ECO:0000269\|PubMed:20604901	260..519		45/251 (18%)
		Membrane-binding amphipathic helix. /evidence=ECO:0000303\|PubMed:19816406	278..295		3/16 (19%)
		BAR	283..516	CDD:386243	40/228 (18%)
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697	1/5 (20%)
		PX_SNX9_18_like	219..343	CDD:132772	33/142 (23%)
		BAR_SNX9_like	362..564	CDD:153310	43/246 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940